京都大学大学院医学研究科 血液・腫瘍内科学

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臨床研究グループ

近藤 忠一(講師)、菱澤 方勝(助教)、諫田 淳也(助教)
恩田 佳幸(大学院4年生)、渡邉 瑞希(大学院2年生)
大森 勝之(研究員)、新堂 真紀(研究員)、松浦 和子(技術補佐員)、塩田 貞子(技術補佐員)
岡 恵(移植コーディネーター)、奥田 智子(CRC)、古阪 絵美(CRC)

当研究室では全国あるいは関連病院との多施設共同臨床研究の企画・推進や、臨床関係のデーターベースの構築、臨床検体の集積・保存システムの構築、造血幹細胞移植の情報管理・研究を行っています。

多施設共同臨床研究のため、京都大学の関連病院による研究グループ KHSG(Kyoto Hematology Study Group)を立ち上げました。このグループにより2012年7月から開始した「再発又は難治性CD20陽性低悪性度B細胞性非ホジキンリンパ腫及びマントル細胞リンパ腫患者を対象にしたベンダムスチン、リツキシマブ併用療法の有効性と安全性の検討:臨床第II相試験」は症例登録が終了しました。現在は、「未治療移植適応多発性骨髄腫患者を対象にしたボルテゾミブを用いた寛解導入・地固め・維持療法および大量抗がん剤併用自家末梢血幹細胞移植の安全性と有効性の検討:臨床第II相試験」、「再発・難治性成人T細胞白血病に対するアバカビルの有効性および安全性に関する多施設共同治験」、「骨髄異形成症候群に対する同種造血幹細胞移植におけるアザシチジンの位置付けに関する多施設共同後方視的疫学研究」などに取り組んでいます。また、院内における単施設でのさまざまな研究にも取り組んでおります。2016年には関連病院と共同で造血幹細胞移植に関する研究グループKSCTG(Kyoto Stem Cell Transplantation Group)を新たに立ち上げました。今後もグループによる臨床研究を発展させていきたいと考えています。

当科で行っている臨床試験についてはこちらのページをご覧ください。

最近の業績(抜粋)

  • Kanda J, Morishima Y, Terakura S, Wake A, Uchida N, Takahashi S, Ono Y, Onishi Y, Kanamori H, Aotsuka N, Ozawa Y, Ogawa H, Sakura T, Ohashi K, Ichinohe T, Kato K, Atsuta Y, Teshima T, Murata M. Impact of graft-versus-host disease on outcomes after unrelated cord blood transplantation. Leukemia. 2017 Mar;31(3):663-668.
  • Yui S, Kurosawa S, Yamaguchi H, Kanamori H, Ueki T, Uoshima N, Mizuno I, Shono K, Usuki K, Chiba S, Nakamura Y, Yanada M, Kanda J, Tajika K, Gomi S, Fukunaga K, Wakita S, Ryotokuji T, Fukuda T, Inokuchi K. D816 mutation of the KIT gene in core binding factor acute myeloid leukemia is associated with poorer prognosis than other KIT gene mutations. Ann Hematol. 2017 Jul 31. [Epub ahead of print]
  • Kawamura K, Kanda J, Fuji S, Murata M, Ikegame K, Yoshioka K, Fukuda T, Ozawa Y, Uchida N, Iwato K, Sakura T, Hidaka M, Hashimoto H, Ichinohe T, Atsuta Y, Kanda Y. Impact of the presence of HLA 1-locus mismatch and the use of low-dose antithymocyte globulin in unrelated bone marrow transplantation. Bone Marrow Transplant. 2017 Jul 17. [Epub ahead of print]
  • Terakura S, Kuwatsuka Y, Yamasaki S, Wake A, Kanda J, Inamoto Y, Mizuta S, Yamaguchi T, Uchida N, Kouzai Y, Aotsuka N, Ogawa H, Kanamori H, Nishiwaki K, Miyakoshi S, Onizuka M, Amano I, Fukuda T, Ichinohe T, Atsuta Y, Murata M, Teshima T. GvHD prophylaxis after single-unit reduced intensity conditioning cord blood transplantation in adults with acute leukemia. Bone Marrow Transplant. 2017 Jun 12. [Epub ahead of print]
  • Akahoshi Y, Kanda J, Ohno A, Komiya Y, Gomyo A, Hayakawa J, Harada N, Kameda K, Ugai T, Wada H, Ishihara Y, Kawamura K, Sakamoto K, Sato M, Terasako-Saito K, Kimura SI, Kikuchi M, Nakasone H, Kako S, Shiraki K, Kanda Y. Acyclovir-resistant herpes simplex virus 1 infection early after allogeneic hematopoietic stem cell transplantation with T-cell depletion. J Infect Chemother. 2017 Jul;23(7):485-487.
  • Yamasaki R, Kanda J, Akahoshi Y, Nakano H, Ugai T, Wada H, Kawamura K, Ishihara Y, Sakamoto K, Sato M, Ashizawa M, Machishima T, Terasako-Saito K, Kimura SI, Kikuchi M, Nakasone H, Yamazaki R, Kako S, Nishida J, Kanda Y. Comparison of levofloxacin and garenoxacin for antibacterial prophylaxis during neutropenia. Int J Hematol. 2017 Jun;105(6):835-840.
  • Hayakawa J, Kanda J, Akahoshi Y, Harada N, Kameda K, Ugai T, Wada H, Ishihara Y, Kawamura K, Sakamoto K, Ashizawa M, Sato M, Terasako-Saito K, Kimura SI, Kikuchi M, Yamazaki R, Kako S, Kanda Y. Meta-analysis of treatment with rabbit and horse antithymocyte globulin for aplastic anemia. Int J Hematol. 2017 May;105(5):578-586.
  • Sakamoto S, Kawabata H, Kanda J, Uchiyama T, Mizumoto C, Kitano T, Kondo T, Hishizawa M, Tomosugi N, Takaori-Kondo A. High pretransplant hepcidin levels are associated with poor overall survival and delayed platelet engraftment after allogeneic hematopoietic stem cell transplantation. Cancer Med. 2017 Jan;6(1):120-128.
  • Yokoyama H, Kanda J, Fuji S, Kim SW, Fukuda T, Najima Y, Ohno H, Uchida N, Ueda Y, Eto T, Iwato K, Kobayashi H, Ozawa Y, Kondo T, Ichinohe T, Atsuta Y, Kanda Y; HLA Working Group of the Japan Society for Hematopoietic Cell Transplantation. Impact of Human Leukocyte Antigen Allele Mismatch in Unrelated Bone Marrow Transplantation with Reduced-Intensity Conditioning Regimen. Biol Blood Marrow Transplant. 2017 Feb;23(2):300-309.
  • Mori T, Kanda Y, Takenaka K, Okamoto S, Kato J, Kanda J, Yoshimoto G, Gondo H, Doi S, Inaba M, Kodera Y. Safety of ASP0113, a cytomegalovirus DNA vaccine, in recipients undergoing allogeneic hematopoietic cell transplantation: an open-label phase 2 trial. Int J Hematol. 2017 Feb;105(2):206-212.
  • Jo T, Arai Y, Kondo T, Kitano T, Hishizawa M, Yamashita K, Takaori-Kondo A. Chronic kidney disease in long-term survivors after allogeneic hematopoietic stem cell transplantation: retrospective analysis at a single institute. Biol Blood Marrow Transplant. 2017, in press.
  • Ogata M, Oshima K, Ikebe T, Takano K, Kanamori H, Kondo T, Ueda Y, Mori T, Hashimoto H, Ogawa H, Eto T, Ueki T, Miyamoto T, Ichinohe T, Atsuta Y,and Fukuda T. Clinical characteristics and outcome of human herpesvirus-6 encephalitis after allogeneic hematopoietic stem cell transplantation. Bone Marrow Transplant. 2017 Aug 7. [Epub ahead of print]
  • Kurosawa S, Oshima K, Yamaguchi T, Yanagisawa A, Fukuda T, Kanamori H, Mori T, Takahashi S, Kondo T, Kohno A, Miyamura K, Umemoto Y, Teshima T, Taniguchi S, Yamashita T, Inamoto Y, Kanda Y, Okamoto S and Atsuta Y. Quality of life after allogeneic hematopoietic cell transplantation according to affected organ and severity of chronic graft-versus-host disease. Biol Blood Marrow Transplant. 2017 Jul 29. [Epub ahead of print]
  • Hijiya K, Chen-Yoshikawa TF, Miyagawa-Hayashino A, Kondo T, Aoyama A, Haga H, Takaori-kondo A, Date H. Pulmonary endothelial chimerism after hematopoietic stem cell transplantation. Surg Today. 2017 Jul 8. [Epub ahead of print]
  • Arai Y, Matsui H, Jo T, Kondo T, Takaori-Kondo A. Efficacy of dexamethasone for acute primary immune thrombocytopenia compared to prednisolone - a systematic review and meta-analysis. Thromb Hemostat Open. 2017, 1(2)e73-81.
  • Tomizawa D, Tanaka S, Kondo T, Hashii Y, Arai Y, Kudo K, Taga T, Fukuda T, Goto H, Inagaki J, Koh K, Ohashi K, Ozawa Y, Inoue M, Kato K, Tanaka J, Atsuta Y, Adachi S, Ishida H. Allogeneic hematopoietic stem cell transplantation for adolescents and young adults with acute myeloid leukemia. Biol Blood Marrow Transplant. 2017 May10. [Epub ahead of print]
  • Oka T, Kobayashi M, Komori T, Nakamine H, Kitano T, Hishizawa M, Kondo T, Yamashita K, Takaori-Kondo A. Follicular lymphoma with plasmacytic differentiation accompanied by monoclonal IgG gammopathy. Rinsho Ketsueki. 58(6): 595-600, 2017.
  • Arai Y, Kondo T, Shigematsu A, Tanaka J, Ohashi K , Fukuda T, Kawakita T, Mori T, Hoshino T, Onizuka M , Ozawa Y, Yoshida S, Ueda Y, Mizuno I, Atsuta Y, and Mizuta Son behalf of the Japan Society for Hematopoietic Cell Transplantation. Increased non-relapse mortality due to high-dose cytarabine plus CY/TBI in BMT/PBSCT for acute lymphoblastic leukemia in adults. Br J Haematol. 178(1): 106-111, 2017.
  • Konuma T, Kondo T, Yamashita T, Uchida N, Fukuda T, Ozawa Y, Ohashi K, Ogawa H, Kato C, Takahashi S, Kanamori H, Eto T, Nakaseko C, Kohno A, Ichinohe T, Atsuta Y, Takami A, Yano S; Adult Acute Myeloid Leukemia Working Group of the Japan Society for Hematopoietic Cell Transplantation (JSHCT). Outcome of allogeneic hematopoietic stem cell transplantation in adult patients with acute myeloid leukemia harboring trisomy 8. Ann Hematol. 96(3): 469-478, 2017.
  • Yamasaki S, Hirakawa A, Aoki J, Uchida N, Fukuda T, Ogawa H, Ohashi K, Kondo T, Eto T, Kanamori H, Okumura H, Iwato K, Ichinohe T, Kanda J, Onizuka M, Kuwatsuka Y, Yanada M, Atsuta Y, Takami A, Yano S. Role of reduced-intensity conditioning allogeneic hematopoietic cell transplantation in older patients with de novo acute myeloid leukemia. Ann Hematol.96(2): 289-297, 2017.
  • Konuma T, Miyazaki Y, Uchida N, Ohashi K, Kondo T, Nakamae H, Takahashi S, Mori T, Ozawa Y,Kato C, Iwato K, Fukuda T, Ichinohe T, Atsuta Y, Ishiyama K; Adult Myelodysplastic Syndrome Working Group of the Japan Society for Hematopoietic Cell Transplantation (JSHCT). Outcomes of allogeneic hematopoietic stem cell transplantation in adult patients with myelodysplastic syndrome harboring trisomy 8. Biol Blood Marrow Transplant.23(1): 75-80, 2017.
  • Fujita M, Kawabata H, Oka T, Hishizawa M, Kitano T, Kondo T, Yamashita K, Yurugi K, Hirai H, Maekawa T, Takaori-Kondo A. A rare case of adult primary autoimmune neutropenia successfully treated with prednisolone. Intern Med. 56(11): 1415-1419, 2017.
  • Takenaka K, Shimoda K, Uchida N, Shimomura T, Nagafuji K, Kondo T, Shibayama H, Mori T, Usuki K, Azuma T, Tsutsumi Y, Tanaka J, Dairaku H, Matsuo K, Ozawa K, Kurokawa M, Arai S and Akashi K. Clinical features and outcomes of patients with primary myelofibrosis in Japan:Report of a 17-year nationwide survey by the Idiopathic Disorders of Hematopoietic Organs Research Committee of Japan. Int J Hematol.105(1): 59-69, 2017.
  • Ishii A, Kondo T, Oka T, Nakamoto Y and Takaori-Kondo A. Granulocytic sarcoma of the pancreas on 18F-FDG PET/CT. A case report. Medicine(Baltimore). 95(49): e5570, 2016.
  • Arai Y, Kondo T, Shigematsu A, Tanaka J, Takahashi S, Kobayashi T, Uchida N,Onishi Y, Ishikawa J, Kanamori H, Sawa M, Yokota A, Kouzai Y, Takanashi M, Ichinohe T, Atsuta Y, and Mizuta S on behalf of the Japan Society for Hematopoietic Cell Transplantation. High-dose cytarabine added to CY/TBI improves the prognosis of cord blood transplantation for acute lymphoblastic leukemia in adults: a retrospective cohort study. Bone Marrow Transplant. 51(12): 1636-1639, 2016.
  • Hirabayashi S, Kondo T, Oka T, Akamatsu Y, Hishizawa M, Shibata T, Kitano T and Takaori-Kondo A. Successful treatment of severe acute gastrointestinal graft-versus-host disease complicated by cytomegalovirus gastroenteritis with intra-arterial steroid infusion. Ann Hematol. 95(8): 1373-1375, 2016.
  • Kitanaka A, Takenaka K, Shide K, Miyamoto T, Kondo T, Ozawa K, Kurokawa M, Akashi K and Shimoda K. Splenic irradiation provides transient palliation for symptomatic splenomegaly associated with primary myelofibrosis: a report on 14 patients. Int J Hematol. 103(4): 423-8, 2016.
  • Sakurada M, Kondo T, Umeda M, Kawabata H, Yamashita K, and Akifum Takaori-Kondo A. Successful treatment with intravesical cidofovir for virus-associated hemorrhagic cystitis after allogeneic hematopoietic stem cell transplantation: A case report and a review of the literature. J Infect Chemother. 22(7): 495-500, 2016.
  • Kato M, Yamashita T, Suzuki R, Matsumoto K, Nishimori H, Takahashi S, Iwato K, Nakaseko C, Kondo T, Imada K, Kimura F, Ichinohe T, Hashii Y, Kato K, Atsuta Y, Taniguchi S, and Fukuda T. Donor cell-derived hematologic malignancy: a survey by the Japan Society for Hematopoietic Cell Transplantation. Leukemia. 30(8): 1742-5, 2016.
  • Nishikori M, Kitawaki T, Tashima M, Shimazu Y, Mori M, Hishizawa M, Kondo T, Ohmori K, Takaori-Kondo A. Diminished CD2 expression in T cells permits tumor immune escape. Journal of Clinical and Cellular Immunology.7: 406, 2016.
  • Aoki J, Seo S, Kanamori H, Tanaka M, Fukuda T, Onizuka M, Kobayashi N, Kondo T, Sawa M, Uchida N, Iwato K, Icihnohe T, Atsuta Y, Yano S and Takami A. Impact of low-dose total body irradiation on outcomes of reduced intensity conditioning allogeneic hematopoietic stem cell transplantation for acute myeloid leukemia. Bone Marrow Transplant. 51(4): 604-6, 2016.
  • Fuji S, Fujiwara H, Nakano N, Wake A, Inoue Y,Fukuda, T, Hidaka M, Moriuchi Y, Miyamoto T, Uike N, Taguchi J, Eto T, Tomoyose T, Kondo T, Yamanoha A, Ichinohe T, Atsuta Y, Utsunomiya A. Early application of related stem-cell transplantation might improve clinical outcome in adult T-cell leukemia/lymphoma. Bone Marrow Transplant. 51(2): 205-11, 2016.
  • Arai Y, Kanda J, Nakasone H, Kondo T, Uchida N, Fukuda T, Ohashi, Kaida, K, Iwato K, Eto T, Kanda Y, Nakamae H, Nagamura-Inoue T, Morishima Y, Hirokawa M, Atsuta Y, and Murata M. Bone Marrow Transplant. 51(1):96-102, 2016.
  • Ishiyama K, Takeda J, Kondo T, Sugimoto N, Kawabata H, Kitano T and Akifumi Takaori-Kondo. Feasibility of salvage cord blood transplantation following fludarabine, melphalan, and low-dose TBI for graft rejection after hematopoietic stem cell transplantation. Bone Marrow Transplant. 51(7): 985-7, 2016.
  • Arai Y, Kondo T, Yamazaki H, Takenaka K, Sugita J, Kobayashi T, Ozawa Y, Uchida N, Iwato K, Kobayashi N, Takahashi Y, Ishiyama K, Fukua T, Ichinohe T, Atsuta Y, Mori T and Teshima T on behalf of the Japan Society for Hematopoietic Cell Transplantation. Allogeneic unrelated bone marrow transplantation from older donors results in worse prognosis in recipients with aplastic anemia. Haematologica. 101(5): 644-52, 2016.
  • Yamazaki H, Aoki K, Kondo T, Nishikori M, Kitano T, Hishizawa M, Yamashita K, Takaori-Kondo A. Outcome of Allogeneic Hematopoietic Stem Cell Transplantation in Cases of Mature T/NK-Cell Neoplasms: A Single-center Retrospective Analysis. Ann Hematol. 96(2): 323-326, 2016.
  • Arai Y, Jo T, Matsui H, Kondo T and Takaori-Kondo A. Efficacy of antithymocyte globulin for allogeneic hematopoietic cell transplantation - a systematic review and meta-analysis. Leuk Lymphoma. 58(8): 1840-1848, 2016.
  • Inamoto Y, Kimura F, Kanda J, Sugita J, Ikegame K, Nakasone H, Nannya Y, Uchida N, Fukuda T, Yoshioka K, Ozawa Y, Kawano I, Atsuta Y, Kato K, Ichinohe T, Inoue M, Teshima T; JSHCT GVHD Working Group. Comparison of graft-versus-host disease-free, relapse-free survival according to a variety of graft sources: antithymocyte globulin and single cord blood provide favorable outcomes in some subgroups. Haematologica. 2016 Dec;101(12):1592-1602.
  • Kanda J, Ikegame K, Fuji S, Kurokawa M, Kanamori H, Fukuda T, Ohashi K, Ishikawa J, Ogawa H, Inoue M, Ichinohe T, Atsuta Y, Kanda Y; HLA Working Group of the Japan Society for Hematopoietic Cell Transplantation. Haploidentical and Matched Sibling Donor Hematopoietic Cell Transplantation for Patients with HLA-Homozygous Haplotypes. Biol Blood Marrow Transplant. 2016 Nov;22(11):2031-2037.
  • Kuwatsuka Y, Kanda J, Yamazaki H, Mori T, Miyamura K, Kako S, Uchida N, Ohashi K, Ozawa Y, Takahashi Y, Kato C, Iwato K, Ishiyama K, Kobayashi H, Eto T, Kahata K, Kato J, Miyamoto T, Kato K, Mori S, Atsuta Y, Kimura F, Kanda Y; Japan Society for Hematopoietic Cell Transplantation. A Comparison of Outcomes for Cord Blood Transplantation and Unrelated Bone Marrow Transplantation in Adult Aplastic Anemia. Biol Blood Marrow Transplant. 2016 Oct;22(10):1836-43.
  • Akahoshi Y, Kanda J, Gomyo A, Hayakawa J, Komiya Y, Harada N, Kameda K, Ugai T, Wada H, Ishihara Y, Kawamura K, Sakamoto K, Sato M, Terasako-Saito K, Kimura S, Kikuchi M, Nakasone H, Kako S, Kanda Y. Risk Factors and Impact of Secondary Failure of Platelet Recovery After Allogeneic Stem Cell Transplantation. Biol Blood Marrow Transplant. 2016 Sep;22(9):1678-83.
  • Teramura Y, Kameda K, Kanda J, Gomyo A, Hayakawa J, Akahoshi Y, Komiya Y, Harada N, Ugai T, Ishihara Y, Kawamura K, Sakamoto K, Sato M, Wada H, Terasako-Saito K, Kimura S, Kikuchi M, Nakasone H, Kako S, Kanda Y. Development tuberculous meningitis during chemotherapy for CD5-positive diffuse large B-cell lymphoma. Rinsho Ketsueki. 2016 May;57(5):597-601.
  • Konuma T, Tsukada N, Kanda J, Uchida N, Ohno Y, Miyakoshi S, Kanamori H, Hidaka M, Sakura T, Onizuka M, Kobayashi N, Sawa M, Eto T, Matsuhashi Y, Kato K, Ichinohe T, Atsuta Y, Miyamura K; Donor/Source Working Group of the Japan Society for Hematopoietic Cell Transplantation. Comparison of transplant outcomes from matched sibling bone marrow or peripheral blood stem cell and unrelated cord blood in patients 50 years or older. Am J Hematol. 2016 May;91(5):E284-92.
  • Kanda J, Brazauskas R, Hu ZH, Kuwatsuka Y, Nagafuji K, Kanamori H, Kanda Y, Miyamura K, Murata M, Fukuda T, Sakamaki H, Kimura F, Seo S, Aljurf M, Yoshimi A, Milone G, Wood WA, Ustun C, Hashimi S, Pasquini M, Bonfim C, Dalal J, Hahn T, Atsuta Y, Saber W. Graft-versus-Host Disease after HLA-Matched Sibling Bone Marrow or Peripheral Blood Stem Cell Transplantation: Comparison of North American Caucasian and Japanese Populations. Biol Blood Marrow Transplant. 2016 Apr;22(4):744-51.
  • Yanada M, Kanda J, Ohtake S, Fukuda T, Sakamaki H, Miyamura K, Miyawaki S, Uchida N, Maeda T, Nagamura-Inoue T, Asou N, Morishima Y, Atsuta Y, Miyazaki Y, Kimura F, Kobayashi Y, Takami A, Naoe T, Kanda Y. Unrelated bone marrow transplantation or immediate umbilical cord blood transplantation for patients with acute myeloid leukemia in first complete remission. Eur J Haematol. 2016 Sep;97(3):278-87.
  • Kanda J. Scripts for TRUMP data analyses. Part II (HLA-related data): statistical analyses specific for hematopoietic stem cell transplantation. Int J Hematol. 2016 Jan;103(1):11-9.
  • Nishikori M, Kitano T, Kobayashi M, Hishizawa M, Kitawaki T, Kondo T, Yamashita K, Kawabata H, Kadowaki N, Takei Y, Haga H, Takaori-Kondo A. Increased number of peripheral CD8+ T cells but not eosinophils is associated with late-onset skin reactions caused by bendamustine. Int J Hematol. 102(1): 53-8, 2015.
  • Arai Y, Takeda J, Aoki K, Kondo T, Takahashi S, Onishi Y, Ozawa Y, Aotsuka N, Kouzai Y, Nakamae H, Ota S, Nakaseko C, Yamaguchi H, Kato K, Atsuta Y, Takami A; AML and MDS Working Group of the Japan Society for Hematopoietic Cell Transplantation. Efficiency of high-dose cytarabine added to CY/TBI in cord blood transplantation for myeloid malignancy. Blood. 2015 Jul 16;126(3):415-22.
  • Aoki T, Suzuki R, Kuwatsuka Y, Kako S, Fujimoto K, Taguchi J, Kondo T, Ohata K, Ito T, Kamoda Y, Fukuda T, Ichinohe T, Takeuchi K, Izutsu K, Suzumiya J. Long-term survival following autologous and allogeneic stem cell transplantation for blastic plasmacytoid dendritic cell neoplasm: A retrospective registry study from the Japan Society for Hematopoietic Cell Transplantation. Blood. 125(23): 3559-62, 2015.
  • Arai Y, Kondo T, Kitano T, Hishizawa M, Yamashita K, Kadowaki N, Yamamoto T, Yano I, Matsubara K, Takaori-Kondo A. Monitoring mycophenol ate mofetil is necessary for the effective prophylaxis of acute graft versus host disease after cord blood transplantation. Bone Marrow Transplant. 50(2): 312-4, 2015.
  • Arai Y, Aoki K, Takeda J, Kondo T, Eto T, Ota S, Hashimoto H, Fukuda T, Ozawa Y, Kanda Y, Kato C, Kurokawa M, Iwato K, Onizuka M, Ichinohe T, Atsuta Y and Takami A. Clinical significance of high-dose cytarabine added to cyclophosphamide/total-body irradiation in bone marrow or peripheral blood stem cell transplantation for myeloid malignancy. J Hematol and Oncol. 4;8;102, 2015.