人工材料

人工材料の基礎研究を行っています。

業績

  1. Otsuki B, Takemoto M, Kawanabe K, Awa Y, Akiyama H, Fujibayashi S, Nakamura T, Matsuda S. Developing a novel custom cutting guide for curved peri-acetabular osteotomy.Int Orthop. 2013 Jun;37(6):1033-8. doi: 10.1007/s00264-013-1873-x. Epub 2013 Apr 9.
  2. Kawai T, Takemoto M, Fujibayashi S, Akiyama H, Yamaguchi S, Pattanayak DK, Doi K, Matsushita T, Nakamura T, Kokubo T, Matsuda S.,Osteoconduction of porous Ti metal enhanced by acid and heat treatments. J Mater Sci Mater Med. 2013 Jul;24(7):1707-15. doi: 10.1007/s10856-013-4919-0. Epub 2013 Mar 27.
  3. Kawai T, Takemoto M, Fujibayashi S, Neo M, Akiyama H, Yamaguchi S, Pattanayak DK, Matsushita T, Nakamura T, Kokubo T.,Bone-bonding properties of Ti metal subjected to acid and heat treatments. J Mater Sci Mater Med. 2012 Dec;23(12):2981-92. doi: 10.1007/s10856-012-4758-4. Epub 2012 Sep 5.
  4. Fujibayashi S, Takemoto M, Neo M, Matsushita T, Kokubo T, Doi K, Ito T, Shimizu A, Nakamura T. A novel synthetic material for spinal fusion: a prospective clinical trial of porous bioactive titanium metal for lumbar interbody fusion. Eur Spine J. 2011 Sep;20(9):1486-95. doi: 10.1007/s00586-011-1728-3. Epub 2011 Mar 3.
  5. Fukuda A, Takemoto M, Saito T, Fujibayashi S, Neo M, Pattanayak DK, Matsushita T, Sasaki K, Nishida N, Kokubo T, Nakamura T. Osteoinduction of porous Ti implants with a channel structure fabricated by selective laser melting. Acta Biomater. 2011 May;7(5):2327-36. doi: 10.1016/j.actbio.2011.01.037. Epub 2011 Feb 2.
  6. Akiyama N, Takemoto M, Fujibayashi S, Neo M, Hirano M, Nakamura T. Difference between dogs and rats with regard to osteoclast-like cells in calcium-deficient hydroxyapatite-induced osteoinduction. J Biomed Mater Res A. 2011 Feb;96(2):402-12. doi: 10.1002/jbm.a.32995. Epub 2010 Dec 8.
  7. Tanaka K, Takemoto M, Fujibayashi S, Neo M, Shikinami Y, Nakamura T.A bioactive and bioresorbable porous cubic composite scaffold loaded with bone marrow aspirate: a potential alternative to autogenous bone grafting. Spine (Phila Pa 1976). 2011 Mar 15;36(6):441-7. doi: 10.1097/BRS.0b013e3181d39067.
  8. Saito T, Takemoto M, Fukuda A, Kuroda Y, Fujibayashi S, Neo M, Honjoh D, Hiraide T, Kizuki T, Kokubo T, Nakamura T. Effect of titania-based surface modification of polyethylene terephthalate on bone-implant bonding and peri-implant tissue reaction. Acta Biomater. 2011 Apr;7(4):1558-69. doi: 10.1016/j.actbio.2010.11.018. Epub 2010 Nov 24.
  9. Fukuda A, Takemoto M, Saito T, Fujibayashi S, Neo M, Yamaguchi S, Kizuki T, Matsushita T, Niinomi M, Kokubo T, Nakamura T. Bone bonding bioactivity of Ti metal and Ti-Zr-Nb-Ta alloys with Ca ions incorporated on their surfaces by simple chemical and heat treatments. Acta Biomater. 2011 Mar;7(3):1379-86. doi: 10.1016/j.actbio.2010.09.026. Epub 2010 Sep 29.
  10. Pattanayak DK, Fukuda A, Matsushita T, Takemoto M, Fujibayashi S, Sasaki K, Nishida N, Nakamura T, Kokubo T. Bioactive Ti metal analogous to human cancellous bone: Fabrication by selective laser melting and chemical treatments. Acta Biomater. 2011 Mar;7(3):1398-406. doi: 10.1016/j.actbio.2010.09.034. Epub 2010 Sep 29.
  11. Kokubo T, Pattanayak DK, Yamaguchi S, Takadama H, Matsushita T, Kawai T, Takemoto M, Fujibayashi S, Nakamura T.Positively charged bioactive Ti metal prepared by simple chemical and heat treatments. J R Soc Interface. 2010 Oct 6;7 Suppl 5:S503-13. doi: 10.1098/rsif.2010.0129.focus. Epub 2010 May 5.
  12. So K, Takemoto M, Fujibayashi S, Neo M, Kokubo T, Nakamura T. Reinforcement of tendon attachment to bioactive porous titanium by BMP-2-induced ectopic bone formation. J Biomed Mater Res A. 2010 Jun 15;93(4):1410-6. doi: 10.1002/jbm.a.32640.
  13. Nasu T, Takemoto M, Akiyama N, Fujibayashi S, Neo M, Nakamura T. EP4 agonist accelerates osteoinduction and degradation of beta-tricalcium phosphate by stimulating osteoclastogenesis. J Biomed Mater Res A. 2009 Jun;89(3):601-8. doi: 10.1002/jbm.a.31984.
  14. Onishi E, Fujibayashi S, Takemoto M, Neo M, Maruyama T, Kokubo T, Nakamura T. Enhancement of bone-bonding ability of bioactive titanium by prostaglandin E2 receptor selective agonist.Biomaterials. 2008 Mar;29(7):877-83. Epub 2007 Nov 28.
  15. Takemoto M, Fujibayashi S, Neo M, So K, Akiyama N, Matsushita T, Kokubo T, Nakamura T. A porous bioactive titanium implant for spinal interbody fusion: an experimental study using a canine model.J Neurosurg Spine. 2007 Oct;7(4):435-43.
  16. Goto K, Hashimoto M, Takadama H, Tamura J, Fujibayashi S, Kawanabe K, Kokubo T, Nakamura T. Mechanical, setting, and biological properties of bone cements containing micron-sized titania particles. J Mater Sci Mater Med. 2008 Mar;19(3):1009-16. Epub 2007 Aug 1.
  17. So K, Takemoto M, Fujibayashi S, Neo M, Kyomoto M, Hayami T, Hyon SH, Nakamura T. Antidegenerative effects of partial disc replacement in an animal surgery model.Spine (Phila Pa 1976). 2007 Jul 1;32(15):1586-91.
  18. Hasegawa S, Neo M, Tamura J, Fujibayashi S, Takemoto M, Shikinami Y, Okazaki K, Nakamura T. In vivo evaluation of a porous hydroxyapatite/poly-DL-lactide composite for bone tissue engineering.J Biomed Mater Res A. 2007 Jun 15;81(4):930-8.
  19. Liang B, Fujibayashi S, Fujita H, Ise K, Neo M, Nakamura T.Long-term follow-up study of bioactive bone cement in canine total hip arthroplasty. J Long Term Eff Med Implants. 2006;16(4):291-9.
  20. Liang B, Fujibayashi S, Fujita H, Ise K, Neo M, Nakamura T. Long-term follow-up study of bioactive bone cement in canine total hip arthroplasty. J Long Term Eff Med Implants. 2006;16(4):291-9
  21. Shikinami Y, Okazaki K, Saito M, Okuno M, Hasegawa S, Tamura J, Fujibayashi S, Nakamura T. Bioactive and bioresorbable cellular cubic-composite scaffolds for use in bone reconstruction. J R Soc Interface. 2006 Aug 8
  22. Otsuki B, Takemoto M, Fujibayashi S, Neo M, Kokubo T, Nakamura T. Pore throat size and connectivity determine bone and tissue ingrowth into porous implants: Three-dimensional micro-CT based structural analyses of porous bioactive titanium implants. Biomaterials. 2006 Dec;27(35):5892-900. Epub 2006 Sep 1.
  23. B. Liang, S. Fujibayashi, H. Fujita, K. Ise, M. Neo, T. Nakamura, “Long-term follow-up study of bioactive bone cement in canine total hip arthroplasty” J. Long Term Eff. Med. Implants, 16, 291-300, (2006)
  24. Goto K, Shinzato S, Fujibayashi S, Tamura J, Kawanabe K, Hasegawa S, Kowalski R, Nakamura T. The biocompatibility and osteoconductivity of a cement containing beta-TCP for use in vertebroplasty. J Biomed Mater Res A. 2006 Sep 1;78(3):629-37.
  25. So K, Fujibayashi S, Neo M, Anan Y, Ogawa T, Kokubo T, Nakamura T. Accelerated degradation and improved bone-bonding ability of hydroxyapatite ceramics by the addition of glass. Biomaterials. 2006 Sep;27(27):4738-44. Epub 2006 Jun 6.
  26. Takemoto M, Fujibayashi S, Neo M, Suzuki J, Kokubo T, Nakamura T. Bone-bonding ability of a hydroxyapatite coated zirconia-alumina nanocomposite with a microporous surface. J Biomed Mater Res A. 2006 May 31;78A(4):693-701
  27. Takemoto M, Fujibayashi S, Neo M, Suzuki J, Matsushita T, Kokubo T, Nakamura T. Osteoinductive porous titanium implants: Effect of sodium removal by dilute HCl treatment. Biomaterials. 2006 May;27(13):2682-91.
  28. Suzuki T, Fujibayashi S, Nakagawa Y, Noda I, Nakamura T. Ability of zirconia double coated with titanium and hydroxyapatite to bond to bone under load-bearing conditions. Biomaterials. 2006 Oct;27(7):996-1002
  29. Hasegawa S, Ishii S, Tamura J, Furukawa T, Neo M, Matsusue Y, Shikinami Y, Okuno M, Nakamura T. A 5-7 year in vivo study of high-strength hydroxyapatite/poly(L-lactide) composite rods for the internal fixation of bone fractures.Biomaterials. 2006 Mar;27(8):1327-32.
  30. Goto K, Tamura J, Shinzato S, Fujibayashi S, Hashimoto M, Kawashita M, Kokubo T, Nakamura T. Bioactive bone cements containing nano-sized titania particles for use as bone substitutes. Biomaterials. 2005 Nov;26(33):6496-505
  31. Takemoto M, Fujibayashi S, Neo M, Suzuki J, Kokubo T, Nakamura T. Mechanical properties and osteoconductivity of porous bioactive titanium. Biomaterials. 2005 Oct;26(30):6014-23
  32. Goto M,Hashimoto M, Fujibayashi S, Kokubo T, Nakamura T. New Bioactive Bone Cement Containing Nano-Sized Titania Particles. Key Engineering Materials Vols. 284-286: 97-100 2005
  33. Hasegawa S, Tamura J, Neo M, Goto K, Shikinami Y, Saito M, Kita M, Nakamura T. In vivo evaluation of a porous hydroxyapatite/poly-DL-lactide composite for use as a bone substitute. J Biomed Mater Res A. 2005 Dec 1;75(3):567-79.
  34. Fujibayashi S, Neo M, Kim HM, Kokubo T, Nakamura T. Osteoinduction of porous bioactive titanium. Biomaterials 25: 443-450 2004
  35. Ohsawa K, Neo M, Okamoto T, Tamura J, Nakamura T. In vivo absorption of porous apatite- and wollastonite-containing glass-ceramic. J Mater Sci Mater Med. 2004 Aug;15(8):859-64.
  36. Shinzato S, Nakamura T, Kawanabe K, Kokubo T. In vivo aging test for a bioactive bone cement consisting of glass bead filler and PMMA matrix. J Biomed Mater Res B Appl Biomater. 2004 Feb 15;68(2):132-9.
  37. Fujibayashi S, Kim HM, Neo M, Uchida M. Kokubo T, Nakamura T. Repair of segmental long bone defect in rabbit femur using bioactive titanium cylindrical mesh cage. Biomaterials 24: 3445-3451 2003
  38. Liang B, Fujibayashi S, Tamura J, Neo M, Kim HM, Uchida M, Kokubo T, Nakamura T. Histological and mechanical investigation of the bone-bonding ability of anodically oxidized titanium in rabbits. Biomaterials. 2003 Dec; 24(27):4959-66.
  39. Nishiguchi S, Fujibayashi S, Kim HM, Kokubo T, Nakamura T. Biology of alkali- and heat-treated titanium implants. J Biomed Mater Res A. 2003 Oct 1;67(1):26-35.
  40. Fujibayashi S, Neo M, Kim HM, Kokubo T, Nakamura T. A comparative study between in vivo bone ingrowth and in vitro apatite formation on Na(2)O-CaO-SiO(2) glasses. Biomaterials. 24(8): 1349-56 2003
  41. Uchida M, Kim HM, Kokubo T, Fujibayashi S, Nakamura T. Structural dependence of apatite formation on titania gels in a simulated body fluid. J Biomed Mater Res. 64(1): 164-70 2003
  42. Ishii S, Tamura J, Furukawa T, Nakamura T, Matsusue Y, Shikinami Y, Okuno M. Long-term study of high-strength hydroxyapatite/poly(L-lactide) composite rods for the internal fixation of bone fractures: a 2-4-year follow-up study in rabbits. J Biomed Mater Res B Appl Biomater. 2003 Aug 15;66(2):539-47.
  43. Tanaka K, Tamura J, Kawanabe K, Nawa M, Uchida M, Kokubo T, Nakamura T. Phase stability after aging and its influence on pin-on-disk wear properties of Ce-TZP/Al2O3 nanocomposite and conventional Y-TZP. J Biomed Mater Res A. 2003 Oct 1;67(1):200-7.
  44. Tanaka K, Tamura J, Kawanabe K, Shimizu M, Nakamura T. Effect of alumina femoral heads on polyethylene wear in cemented total hip arthroplasty. Old versus current alumina. J Bone Joint Surg Br. 2003 Jul;85(5):655-60.
  45. Shinzato S, Nakamura T, Kawanabe K, Kokubo T. PMMA-based bioactive cement: effect of CaF2 on osteoconductivity and histological change with time. J Biomed Mater Res B Appl Biomater. 2003 May 15;65(2):262-71.
  46. Tanaka K, Tamura J, Kawanabe K, Nawa M, Oka M, Uchida M, Kokubo T, Nakamura T. Ce-TZP/Al2O3 nanocomposite as a bearing material in total joint replacement. J Biomed Mater Res. 2002;63(3):262-70.
  47. Kamimura M, Tamura J, Shinzato S, Kawanabe K, Neo M, Kokubo T, Nakamura T. Interfacial tensile strength between polymethylmethacrylate-based bioactive bone cements and bone. J Biomed Mater Res. 2002 Sep 15;61(4):564-71.
  48. Shinzato S, Nakamura T, Kokubo T, Kitamura Y. Composites consisting of poly(methyl methacrylate) and alumina powder: an evaluation of their mechanical and biological properties. J Biomed Mater Res. 2002 Jun 15;60(4):585-91.
  49. Shinzato S, Nakamura T, Ando K, Kokubo T, Kitamura Y. Mechanical properties and osteoconductivity of new bioactive composites consisting of partially crystallized glass beads and poly(methyl methacrylate). J Biomed Mater Res. 2002 Jun 15;60(4):556-63.
  50. Shinzato S, Nakamura T, Kokubo T, Kitamura Y. PMMA-based bioactive cement: effect of glass bead filler content and histological change with time.J Biomed Mater Res. 2002 Feb;59(2):225-32.
  51. Fujibayashi S, Senaha Y, Yoshihara S, Tamura J, Nakamura T. Long-term follow-up study of bioactive bone cement for repairing a segmental defect in a canine femur. J Long Term Eff Med Implants. 11(1-2): 93-103 2001
  52. Fujibayashi S, Nakamura T, Nishiguchi S, Tamura J, Uchida M, Kim HM, Kokubo T. Bioactive titanium: effect of sodium removal on the bone-bonding ability of bioactive titanium prepared by alkali and heat treatment. J Biomed Mater Res. 56(4):562-70 2001
  53. Ohsawa K, Neo M, Matsuoka H, Akiyama H, Ito H, Nakamura T. Tissue responses around polymethylmethacrylate particles implanted into bone: analysis of expression of bone matrix protein mRNAs by in situ hybridization. J Biomed Mater Res. 2001 Mar 15;54(4):501-8.
  54. Shinzato S, Nakamura T, Kokubo T, Kitamura Y. A new bioactive bone cement: effect of glass bead filler content on mechanical and biological properties. J Biomed Mater Res. 2001 Mar 15;54(4):491-500.
  55. Shinzato S, Nakamura T, Tamura J, Kokubo T, Kitamura Y. Bioactive bone cement: effects of phosphoric ester monomer on mechanical properties and osteoconductivity. J Biomed Mater Res. 2001 Sep 15;56(4):571-7.
  56. Shinzato S, Nakamura T, Kokubo T, Kitamura Y. Bioactive bone cement: effect of filler size on mechanical properties and osteoconductivity. J Biomed Mater Res. 2001 Sep 5;56(3):452-8.
  57. Shinzato S, Nakamura T, Kokubo T, Kitamura Y. Bioactive bone cement: Effect of silane treatment on mechanical properties and osteoconductivity. J Biomed Mater Res. 2001 Jun 5;55(3):277-84.
  58. Nishiguchi S, Kato H, Fujita H, Oka M, Kim HM, Kokubo T, Nakamura T. Titanium metals form direct bonding to bone after alkali and heat treatments. Biomaterials. 2001 Sep;22(18):2525-33.
  59. Nishiguchi S, Kato H, Neo M, Oka M, Kim HM, Kokubo T, Nakamura T. Alkali- and heat-treated porous titanium for orthopedic implants.J Biomed Mater Res. 2001 Feb;54(2):198-208.