| Year | Month | |
|---|---|---|
| 1899 | 7 | Kyoto Imperial University College of Medicine established. |
| 12 | Kyoto Imperial University College of Medicine Hospital opened. | |
| 1919 | 2 | Kyoto Imperial University College of Medicine Hospital renamed the Kyoto Imperial University Hospital. |
| 1947 | 9 | Kyoto Imperial University renamed Kyoto University |
| 1949 | 5 | Kyoto Imperial University College of Medicine Hospital renamed the Kyoto University Hospital |
| 1958 | 2 | Central Medical Ward established. |
| 1962 | 4 | Department of Pharmacy established |
| 1964 | 3 | Outpatient Care Ward established. |
| 1976 | 5 | Nursing Department established. |
| 1978 | 3 | RI Medical Ward established. |
| 1985 | 3 | MR Ward established. |
| 1987 | 10 | First Clinical Research Ward established. |
| 11 | General Internal Medicine Ward established. | |
| 1992 | 1 | Central Medical Facility Ward established. Second Clinical Research Ward established. |
| 1995 | 6 | Ward names changed. General Internal Medicine Ward changed to North Ward; General Surgical Ward changed to South Ward, to North Ward; General Surgical Ward changed to South Ward |
| 1998 | 4 | Integrated with the Chest Disease Research Institute. |
| 1999 | 8 | Outpatient Care Ward established. |
| 2000 | 1 | Treatment and examination at the new Outpatient Ward begin under the organ-specific treatment setup. |
| 2003 | 3 | Central Medical Center established |
| 2007 | 4 | Kyoto University Cancer Center established. |
| 2010 | 3 | Sekitei Ward established. |
| 2011 | 6 | Clinical Research Center for Medical Equipment Development (CRCMED) Ward established. |
| 2013 | 4 | Institute of Advancement Clinical and Translational Science established. |
| 2015 | 4 | Pre-emptive Medicine and Lifestyle-Related Disease Research Center established. |
| 12 | South Ward established. | |
| 2017 | 3 | Designated as Clinical Research Core Hospital. |
| 2018 | 3 | ISO 9001 certification acquired |
| 4 | Designated as Cancer Genome Medicine Core Hospital. | |
| 2019 | 4 | Patient Support Center established. Center for Maternal, Fetal and Neonatal Medicine established. |
| 9 | Middle Ward and Ki-CONNECT(Kyoto innovation Center for Next Generation Clinical Traials and iPS Cell Therapy) established |