食欲と脂肪蓄積の制御と破綻の分子基盤の解明【平成22年度 新学術領域研究(研究領域提案型)】

研究成果

■2015
【業績論文】
研究代表者、研究分担者は一重下線、corresponding authorは左に*印で明示
≪計画研究≫

寒川
1.  Nojiri T, Miyazato M, Kangawa K(11人中9,11番目). Atrial natriuretic peptide protects against cisplatin-induced acute kidney injury. Cancer Chemother Pharmacol, 75:, 123-129, 2015 査読有
2.  Yoshihara F, Kishimoto I, Kangawa K(8人中3,8番目). Aggravated renal tubular damage and interstitial fibrosis in mice lacking guanylyl cyclase-A (GC-A), a receptor for atrial and B-type natriuretic peptides. Clin Exp Nephrol, 19: 197-207, 2015 査読有
3.  Matsumoto N, Kangawa K(20人中20番目). Ghrelin Administration for Chronic Respiratory Failure: A Randomized Dose-Comparison Trial. Lung, 193: 239-247, 2015 査読有
4.  Kimura T, Miyazato M, Kangawa K(9人中7,9番目). C-type natriuretic peptide attenuates lipopolysaccharide-induced acute lung injury in mice. J Surg Res, 194: 631-637, 2015 査読有

児島
1.  Sano H, Kojima M(10人中1,10番目). Nutrient-sensitive hormone CCHamide-2 controls growth through insulin/IGF production in the brain of Drosophila melanogaster. PLoS Genetics (in press) 査読有
2.  Shiimura Y, Sato T, Kojima M(4人中3,4番目). Regulation of the Human Ghrelin Promoter Activity by Transcription Factors, NF-κB and Nkx2.2. International Journal of Endocrinology, Volume 2015, Article ID 580908, 2015. 査読有

塩田
1.  Takenoya F, Kageyama H, Hirako S, Shioda S(10人中1,3,410番目). Neuropeptide W-Induced Hypophagia is Mediated Through Corticotropin-Releasing Hormone-Containing Neurons. J Mol Neurosci. 2015 Feb 19. [Epub ahead of print] 査読有


1.   脇 裕典: 褐色細胞組織の機能制御とその破綻. 医学のあゆみ(第5土曜特集 糖尿病のすべて 基礎研究の最前線), 252 (5) 2015年1月 p415-419. 査読無

船橋
1.  Fukuda S, Nishizawa H, Maeda N, Funahashi T(16人中3,13,15番目). Systemic arteriosclerosis and eating behavior in Japanese type 2 diabetic patients with visceral fat accumulation. Cardiovasc Diabetol. 14: 8, 2015. 査読有
2.  Matsuda K, Maeda N, Nishizawa H, Funahashi T(15人中3,11,14番目). Positive feedback regulation between adiponectin and T-cadherin impacts adiponectin levels in tissue and plasma of male mice. Endocrinology. 156: 934-946, 2015. 査読有
3.  Sekimoto R, Maeda N, Funahashi T(13人中3,11番目). Visualized macrophage dynamics and significance of S100A8 in obese fat. Proc Natl Acad Sci U S A. 112: E2058-2066. , 2015 査読有

中里
1.  Matsumoto N, Tsubouchi H, Nakazato M(20人中3,19番目), Kangawa K: Ghrelin administration for chronic respiratory failure: a randomized dose-comparison trial. Lung, 193: 239-247, 2015. 査読有
2.  Tsuchimochi W, Ueno H(7人中2番目), Nakazato M(7人中2,7番目): Teneligliptin improves glycemic control with the reduction of postprandial insulin requirement in Japanese diabetic patients. Endocr J, 62: 13-20, 2015. 査読有
3.  Kim JW, Yamaguchi H, Nakazato M(9人中4,7番目): Chronic effects of neuroendocrine regulatory peptide (NERP-1 and -2) on insulin secretion and gene expression in pancreatic β-cells. Biochem Biophys Res Commun, 457: 148-153, 2015. 査読有

≪公募研究≫
[平成25年度~平成26年度]
井上順
1.   Shimizu M, Inoue J(5人中4番目). Selective regulation of FGF19 and FGF21 expression by cellular and nutritional stress. J Nutr Sci Vitaminol, in press査読有
2.  Shimizu M, Inoue J(4人中3番目). Quercetin represses apolipoprotein B expression by inhibiting the transcriptional activity of C/EBPβ. PLoS ONE, in press査読有

稲垣
1.  Inagaki T(18人中1番目). The FBXL10/KDM2B scaffolding protein associates with novel polycomb repressive complex-1 to regulate adipogenesis. J Biol Chem, 290: 4163-4177, 2015.査読有

菅波
1.  Konuma K, Suganami T(11人中3番目). Eicosapentaenoic acid ameliorates non-alcoholic steatohepatitis in a novel mouse model using Melanocortin 4 receptor-deficient mice. PLoS ONE, 10: e0121528, 2015. 査読有

長井
1.  Yanagibashi T, Nagai Y(6人中2番目). Differential Requirements of MyD88 And TRIF Pathways in TLR4-mediated Immune Responses in Murine B Cells. Immunol Letters, 163: 22-31, 2015. 査読有

三枝
1.  Mieda M(7人中1番目), et al. Cellular clocks in AVP neurons of the SCN are critical for interneuronal coupling regulating circadian behavior rhythm. Neuron, 85: 1103-1116, 2015. 査読有

井上啓
1.  Inaba Y, *Inoue H(14名中14番目). Gadd34 regulates liver regeneration in hepatic steatosis. Hepatology, in press, 2015. 査読有
2.  Tsuneki H, Inoue H(15名中12番目). Hypothalamic orexin prevents hepatic insulin resistance via daily bidirectional regulation of autonomic nervous system in mice. Diabetes, 64: 459-470, 2015. 査読有

藤本
1.  Imai N, Fujimoto T (9名中9番目). Hepatocyte-specific depletion of UBXD8 induces periportal steatosis in mice fed a high-fat diet. PLoS ONE 10: e0127114, 2015. 査読有

岩倉
1.  Iwakura H (3人中1番目). The regulation of circulating ghrelin - with recent updates from cell-based assays [Review]. Endocr J, 62:107-122, 2015. 査読有

和田
1.  Hishikawa N, Wada J(7名中4番目). Cognitive and affective functions in diabetic patients associated with diabetes-related factors, white matter abnormality and aging. Eur J Neurol 22: 313-321, 2015. 査読有
2.  Ohashi M, Wada J(13名中7番目). Structural design and synthesis of arylalkynyl amide-type peroxisome proliferator-activator receptor γ (PPARγ)-selective antagonists based on the helix12-folding inhibition hypothesis. Eur J Med Chem 90, 53-67, 2015. 査読有
3.  Higuchi C, Wada J(13名中13番目). Identification of circulating miR-101, miR-375 and miR-802 as biomarkers for type 2 diabetes. Metabolism 64, 489-497, 2015. 査読有
4.  Wang Y, Wada J(14名中14番目). Translocase of inner mitochondrial membrane 44 alters the mitochondrial fusion and fission dynamics and protects from type 2 diabetes. Metabolism, 64: 677-688, 2015. 査読有

浮穴
1.  Masuda K, Ukena K(4名中4番目). Effects of neurotensin and LANT-6 on food intake in chicks. Am J Life Sci, 3: 17-23, 2015. 査読有
2.  Masuda K, Ukena K(7名中7番目).Microwave-assisted solid-phase peptide synthesis of neurosecretory protein GL composed of 80 amino acid residues. J Pept Sci, 21: 454-460, 2015. 査読有
3.  Sasanami T,Ukena K(11名中10番目). A unique mechanism of successful fertilization in a domestic bird. Sci Rep, 5: 7700, 2015. 査読有
4.  Tachibana T, Ukena K(7名中6番目). Central administration of chicken growth hormone-releasing hormone decreases food intake in chicks. Physiol Behav, 139: 195-201, 2015. 査読有

阪上
1.  Miyatake Y, Sakaue H(13名中13番目). Intracerebroventricular injection of adiponectin regulates locomotor activity in rats. J Med Invest, in press. 査読有

西尾
1.  Yamamoto-Kataoka S, Nishio M(14人中4番目). Leptin improves fatty liver independently of insulin sensitization and appetite suppression in hepatocytespecific Pten-deficient mice with insulin hypersensitivity.Horm Metab Res, 47: 168-175, 2015. 査読有

井田
1.  Sano H, Ida T(3人中2番目). The nutrient-responsive hormone CCHamide-2 controls growth by regulating insulin-like peptides in the brain of Drosophila melanogaster. PLoS Genetics, in press.
2.  Sato T, Ida T(4人中3番目). Physiological functions and pathology of ghrelin. American Journal of Life Sciences, in press.
3.  Ida T(4人中1番目). Identification and application of Drosophila novel bioactive peptides dRYamides. American Journal of Life Sciences, in press.

亀井
1.  Ehara T, Kamei Y(15人中2番目). Ligand-activated PPARα-dependent DNA demethylation regulates the fatty acid β-oxidation genes in the postnatal liver. Diabetes, 64: 775-784, 2015. 査読有

中島
1.  Endo H, Nakajima A(7人中7番目). Small bowel injury in low-dose aspirin users. J Gastroenterol, 50: 378-386, 2015. 査読有

河野
1Kohno D(9人中1番目). Dnmt3a in Sim1 neurons is necessary for normal energy homeostasis. J Neurosci, 34: 15288-15296, 2015. 査読有

船戸
1.  Oda S, Funato H(7人中2番目). A subset of thalamocortical projections to the retrosplenial cortex possesses two vesicular glutamate transporter isoforms, VGluT1 and VGluT2, in axon terminals as well as somata. Journal of Comparative Neurology, 522: 2089-210, 2015. 査読有

高田
1.  Kawano S, Takada T(4人中3番目). Sparse principal component regression with adaptive loading. Computational Statistics & Data Analysis, in press, 2015. 査読有

土田
1.  Ikemoto-Uezumi M, Tsuchida K(8人中3番目). Pro-IGF-II ameliorates age-related inefficient regenerative response by orchestrating self-reinforcement mechanism of muscle regeneration. Stem Cells, in press, 2015. 査読有

松本
1.  Inaba Y, Matsumoto M(14人中7番目). Gadd34 regulates liver regeneration in hepatic steatosis. Hepatology, 61: 1343-1356, 2015. 査読有
2.  Cook JR, Matsumoto M(6人中2番目). A Mutant Allele Encoding DNA-Binding-Deficient Foxo1 Differentially Regulates Hepatic Glucose and Lipid Metabolism. Diabetes, in press, 2015. 査読有

[平成23年度~平成24年度]
斉藤
1.  Kobayashi Y, Saito Y(4人中4番目). Molecular cloning, expression, and signaling pathway of four melanin-concentrating hormone receptors from Xenopus tropicalis. General and Comparative Endocrinology, 212: 114-123, 2015. 査読有
2.  Hamamoto A, Saito Y(3人中3番目).. Identification of amino acids that are selectively involved in Gi/o activation by the rat melanin-concentrating hormone receptor 1. Cellular Signaling, 27: 818-827, 2015. 査読有
3.  Mizusawa K, Saito Y(7人中6番目). Involvement of melanin-concentrating hormone 2 in background color adaptation of barfin flounder Verasper moseri. General and Comparative Endocrinology, 214: 140-148, 2015. 査読有

前島
1.  Maejima Y(9人中1番目). Nasal oxytocin administration reduce food intake without affecting locomotor activity and glycemia with c-Fos induction in limited brain areas. Neuroendocrinology, 101: 35-44, 2015. 査読有
2.  Iwasaki Y, Maejima Y(10人中2番目). Peripheral oxytocin activates vagal afferent neurons to suppress feeding in normal and leptin-resistant mice: a route for ameliorating hyperphagia and obesity. Am J Physiol Regul Integr Comp Physiol, 308: R360-369, 2015. 査読有

海老原
1.  Yamamoto-Kataoka S, Ebihara K(14人中2番目). Leptin improves fatty liver independently of insulin sensitization and appetite suppression in hepatocyte-specific Pten-deficient mice with insulin hypersensitivity. Horm Metab Res, 47: 168-175, 2015. 査読有


【受賞】
岡本士毅/生理学研究所 発達生理学研究系 助教
第3回生活習慣病の分子細胞病態学研究会ポスターセッション最優秀賞(平成27年3月14日)
「ストレス誘導性炭水化物食選択行動に及ぼす視床下部AMPKの調節作用」

八木 孝/国立国際医療研究センター研究所 糖尿病研究センター 分子代謝制御研究部・研究生
日本糖尿病・肥満動物学会・若手研究奨励賞(平成27年2月13日)
「肝臓特異的な脂肪酸合成酵素の欠損はob/obマウスの脂肪肝と耐糖能を改善するが随時高血糖を惹起する」


■2014
【業績
文】
研究代表者、研究分担者は一重下線、corresponding authorは左に*印で明示
≪計画研究≫
寒川
1.  Habara H, Kangawa K(5人中5番目). Organ-specific activation of the gastric branch of the efferent vagus nerve by ghrelin in urethane-anesthetized rats. J Pharmacol Sci, 124: 31-39, 2014. 査読有
2.  Kaiya H, Kangawa K(3人中2番目), Miyazato M: Molecular evolution of GPCRs: Ghrelin/ghrelin receptors. J Mol Endocrinol, 52: T87-T100, 2014. 査読有
3.  Kaiya H, Kangawa K(5人中3番目), Miyazato M: Identification, tissue distribution and functional characterization of the ghrelin receptor in West African lungfish, Protopterus annectens. Gen Comp Endocrinol, 209: 106-117, 2014. 査読有
4.  Takayama K, Miyazato M, Kangawa K(9人中7,8番目). Discovery of selective hexapeptide agonists to human neuromedin U receptors types 1 and 2. J Med Chem, 57: 6583-6593, 2014. 査読有
5.  Tsubouchi H, Kangawa K(6人中5番目). Ghrelin relieves cancer cachexia associated with the development of lung adenocarcinoma in mice. Eur J Pharmacol, 743: 1-10, 2014. 査読有
6.  Soeki T, Kishimoto I, Kangawa K(12人中2,11番目). Effect of ghrelin on autonomic activity in healthy volunteers. Peptides, 62: 1-5, 2014. 査読有
7.  Mao Y, Kishimoto I, Miyazato M, Kangawa K(6人中3,5,6番目). One dose of oral hexarelin protects chronic cardiac function after myocardial infarction. Peptides, 56: 156-162, 2014. 査読有
8.  Nojiri T, Miyazato M, Kangawa K(12人中10,12番目). Atrial natriuretic peptide inhibits lipopolysaccharide-induced acute lung injury. Pulm Pharmacol Ther, 29: 24-30, 2014. 査読有

児島
1.  Sato T, Kojima M(6人中1,6番目). Physiological roles of ghrelin on obesity. Obes Res Clin Pract, 8 : e405-413, 2014. 査読有

塩田
1.  Suzuki Y, Kageyama H, Hirako S, Shioda S(15人中7,9,12番目). Vagal hyperactivity due to ventromedial hypothalamic lesions increases adiponectin production and release. Diabetes, 63: 1637-1648, 2014. 査読有
2.  Wada N, Hirako S, Takenoya F, Kageyama H, Shioda S(6人中2,3,4,6番目). Leptin and its receptors. J Chem Neuroanat, 61-62: 191-199, 2014. 査読有

片桐
1.   Imai J, Katagiri H(4人中4番目). Type B insulin resistance syndrome as an H. Pylori-associated autoimmune disease. Journal of Endocrinology, Diabetes & Obesity, 2: 1026, 2014. 査読有
2.   Tanaka M, Katagiri H(13人中13番目). Glycemic control in diabetic patients with impaired endogenous insulin secretory capacity is vulnerable after a natural disaster: study of Great East Japan Earthquake. Diabetes Care, 37: e212-e213, 2014. 査読有
3.   Kodama S, Katagiri H(11人中11番目). Simultaneous copy number losses within multiple subtelomeric regions in early-onset type 2 diabetes mellitus. PLoS One, 9: e88602, 2014. 査読有
4.   Noda K, Katagiri H(12人中11番目). Rho-Kinase Inhibition Ameliorates Metabolic Disorders through Activation of AMPK Pathway in Mice. PLoS One, 9: e110446, 2014. 査読有

箕越
1.  Inagaki-Ohara K, Minokoshi Y(9人中4番目). Enhancement of leptin receptor signaling by SOCS3 deficiency induces development of gastric tumors in mice. Oncogene, 33:74-84, 2014. 査読有
2.  Sasaki T, Minokoshi Y(21人中18番目). Hypothalamic SIRT1 prevents age-associated weight gain by improving leptin sensitivity in mice. Diabetologia, 57: 819-831, 2014. 査読有
3.  Tabuchi S, Minokoshi Y(10人中7番目). Conditional ablation of orexin/hypocretin neurons: a new mouse model for the study of narcolepsy and orexin system function. J Neurosci, 34: 6495-6509, 2014. 査読有


1.  脇 裕典, 山内敏正, 門脇 孝. 糖尿病と遺伝子 4.糖尿病とエピゲノム 糖尿病, 57 (2) 2014年2月 p91-93. 査読無
2.  脇 裕典, 山内 敏正, 門脇 孝. エピゲノムと肥満症 医学のあゆみ (第5土曜特集 肥満の医学 : 臨床と研究の最先端), 250 (9) 2014年8月 p797-801. 査読無
3.  中村正裕, 脇 裕典. プロトコール エピゲノム C.クロマチンアクセシビリティ解析 2.オープンクロマチンを同定するFAIRE-seq 実験医学別冊 次世代シークエンス解析スタンダード, 2014年9月 p195-203. 査読無

中里
1.  Tsubouchi H, Nakazato M(8人中1番目). Rikkunshito ameliorates bleomycin-induced acute lung injury in a ghrelin-independent manner.Am J Physiol Lung Cell Mol Physiol, 306: L233-245, 2014. 査読有
2.  Yano Y, Nakazato M, Toshinai K(9人中2,3番目). Circulating des-acyl ghrelin improves cardiovascular risk prediction in older hypertensive patients. Am J Hypertens, (9人中4番目), 27: 727-733, 2014. 査読有
3.  Toshinai K, Yamaguchi H, Nakazato M8人中1,3,8番目). Neuroendocrine regulatory peptide-1 and -2 (NERPs) inhibit the excitability of magnocellular neurosecretory cells in the hypothalamus. Brain Res, 1563:  52-60, 2014. 査読有
4.  Ueno H, Nakazato M(8人中1,8番目). Exploratory trial of intranasal administration of glucagon-like peptide-1 in Japanese patients with type 2 diabetes. Diabetes Care, 37: 2024-2027, 2014. 査読有
5.  Tsubouchi H, Nakazato M(6人中1,6番目). Ghrelin relieves cancer cachexia associated with the development of lung adenocarcinoma in mice. Eur J Pharmacol, 743: 1-10, 2014. 査読有
6.  Tsubouchi H, Nakazato M(8人中1,8番目). Rikkunshito ameliorates cachexia associated with bleomycin-induced lung fibrosis in mice by stimulating ghrelin secretion. Nutr Res, 34: 876-885, 2014. 査読有

船橋
1.  Kishida K, Funahashi T(8人中1,7番目).High serum C1q-binding adiponectin levels in male patients with acute coronary syndrome. Cardiovasc Diabetol, 13: 9, 2014. 査読有
2.  Fujishima Y, Maeda N, Nishizawa H, Funahashi T(11人中2,9,10番目).Effect of adiponectin on cardiac β-catenin signaling pathway under angiotensin II infusion. Biochem Biophys Res Commun, 444: 224-229, 2014. 査読有
3.  Nakatsuji H, Kishida K, Funahashi T(7人中2,6番目). Accumulation of adiponectin in inflamed adipose tissues of obese mice. Metabolism, 63: 542-53, 2014. 査読有
4.  Inoue K, Maeda N, Nishizawa H, Funahashi T(12人中2,9,11番目).Possible involvement of Opa-interacting protein 5 in adipose proliferation and obesity. PLoS One, 9: e87661, 2014. 査読有
5.  Nakatsuji H, Kishida K, Funahashi T(5人中2,4番目). Tracing the movement of adiponectin in a parabiosis model of wild-type and adiponectin-knockout mice. FEBS Open Bio, 4: 276-282, 2014. 査読有
6.  Mori T, Maeda N, Funahashi T(9人中3,7番目). Ultrastructural localization of adiponectin protein in vasculature of normal and atherosclerotic mice. Sci Rep, 4: 4895, 2014. 査読有
7.  Kishida K, Funahashi T(6人中1,5番目). Increased serum C1q-binding adiponectin complex to total-adiponectin ratio in men with multi-vessel coronary disease. Diabetol Metab Syndr, 6: 64, 2014. 査読有
8.  Yamaoka M, Maeda N, Nishizawa H, Funahashi T(12人中2,9,11番目). Adipose hypothermia in obesity and its association with period homolog 1, insulin sensitivity, and inflammation in fat. PLoS One, 9: e112813, 2014. 査読有

清水
1.  Suzuki Y, Shimizu H(15人中2番目). Vagal hyperactivity due to ventromedial hypothalamic lesions increases adiponectin production and release. Diabetes 63: 1637-1648, 2014. 査読有
2.  Shimizu H, Osaki A(2人中1,2番目). Possible involvement of anorexigenic protein, nesfatin/nucleobindin-2 (NUCB2) in blood pressure regulation by regulating water reabsorption in renal collecting duct. J Cytology and Histology 5: 290, 2014. 査読有

小川
1.  Uchimura K, Ogawa W(19人中13番目). The serine protease prostasin regulates hepatic insulin sensitivity by modulating TLR4 signalling. Nat Commun, 5: 3428, 2014. 査読有

細田
1.  Sakai T, Hosoda K(15人中13番目). Leptin restores the insulinotropic effect of exenatide in a mouse model of type 2 diabetes with increased adiposity induced by streptozotocin and high-fat diet. Am J Physiol Endocrinol Metab, 307: E712-719, 2014. 査読有
2.  Tomita T, Hosoda K(5人中1,2番目). The G-Protein-Coupled Long-Chain Fatty Acid Receptor GPR40 and Glucose Metabolism. Front Endocrinol (Lausanne), 5: 152, 2014. 査読有

≪公募研究≫
[平成25年度~平成26年度]
島野
1.  Han SI, Shimano H(14人中12番目). Estrogen receptor ligands ameliorate fatty liver through a nonclassical estrogen receptor/Liver X receptor pathway in mice. Hepatology, 59: 1791-1802, 2014. 査読有
2.  Hamada M, Shimano H(21人中18番目). MafB promotes atherosclerosis by inhibiting foam-cell apoptosis. Nat Commun, 5: 3147, 2014. 査読有
3.  Fujihara K, Shimano H(14人中14番目). Comparison of the Framingham Risk Score, UK Prospective Diabetes Study (UKPDS) Risk Engine, Japanese Atherosclerosis Longitudinal Study-Existing Cohorts Combine (JALS-ECC) and Maximum Carotid Intima-Media Thickness for Predicting Coronary Artery Stenosis in Patients with Asymptomatic Type 2 Diabetes. J Atheroscler Thromb, 21: 799-815, 2014. 査読有
4.  Nakakuki M, Shimano H(6人中6番目). A novel processing system of sterol regulatory element-binding protein-1c regulated by polyunsaturated fatty acid. J Biochem, 155 : 301-303, 2014. 査読有
5.  Tanaka Y, Shimano H(21人中21番目). Hara H, Kawakami Y, Takekoshi K. Plasma free metanephrines in the diagnosis of pheochromocytoma: diagnostic accuracy and strategies for Japanese patients. Endocr J, 61: 667-673, 2014. 査読有
6.  Horie T, Shimano H(21人中14番目)., Nakamura T, Hasegawa K, Kume N, Yokode M, Kita T, Kimura T, Ono K. MicroRNA-33b knock-in mice for an intron of sterol regulatory element-binding factor 1 (Srebf1) exhibit reduced HDL-C in vivo. Sci Rep, 4:5312 2014. 査読有
7.  Tang N, Shimano H(21人中21番目). Ablation of Elovl6 protects pancreatic islets from high-fat diet-induced impairment of insulin secretion. Biochem Biophys Res Commun, 450: 318-323, 2014. 査読有
8.  Fujihara K, Shimano H(11人中8番目). Utility of the Triglyceride Level for Predicting Incident Diabetes Mellitus According to the Fasting Status and Body Mass Index Category: The Ibaraki Prefectural Health Study. J Atheroscler Thromb, 21: 1152-1169, 2014. 査読有
9.  Horikawa C, Shimano H(9人中8番目). High risk of failing eradication of Helicobacter pylori in patients with diabetes: A meta-analysis. Diabetes Res Clin Pract, 106: 81-87, 2014. 査読有
10. Nakagawa Y, Shimano H(31人中31番目). Hepatic CREB3L3 Controls Whole-Body Energy Homeostasis and Improves Obesity and Diabetes. Endocrinology, 155: 4706-4719, 2014. 査読有

井上順
1.  Sasaki T, Inoue J(6人中5番目). The role of AMPK and PPARγ1 in exercise-induced lipoprotein lipase in skeletal muscle. Am J Physiol Endocrinol Metab, 306: E1085-E1092, 2014. 査読有

菅波
1.  Tanaka M, Suganami T(16人中3番目). Macrophage-inducible C-type lectin underlies obesity-induced adipose tissue fibrosis. Nat Commun, 5: 4982, 2014. 査読有
2.  Iwasaki Y, Suganami T(11人中2番目). Activating transcription factor 4 links metabolic stress to interleukin-6 expression in macrophages. Diabetes, 63: 152-161, 2014. 査読有

南野
1.  Suzuki H, Minamino T(7人中5番目). Short QT syndrome in a boy diagnosed on screening for heart disease. Pediatr Int, 56(5): 774-776, 2014. 査読有
2.  Suzuki T, Minamino T(9人中9番目). Inappropriate expression of hepcidin by liver congestion contributes to anemia and relative iron deficiency. J Card Fail, 20: 268-277, 2014. 査読有
3.  Suzuki H, Minamino T(12人中10番目). Arachidonate 12/15-lipoxygenase-induced inflammation and oxidative stress are involved in the development of Diabetic Cardiomyopathy. Diabetes, 64: 618-630, 2014. 査読有
4.  Ito TK, Minamino T(12人中12番目). A crucial role for CDC42 in senescence-associated inflammation and atherosclerosis. PLoS One, 9: e102186, 2014. 査読有
5.  Kitada K, Minamino T(11人中5番目). Hyperglycemia causes cellular senescence via a SGLT2- and p21-dependent pathway in proximal tubules in the early stage of diabetic nephropathy. J Diabetes Complications, 28: 604-611, 2014. 査読有
6.  Yoshida Y, Minamino T(12人中12番目). Notch signaling regulates the lifespan of vascular endothelial cells via a p16-dependent pathway. PLoS One, 9: e100359, 2014. 査読有
7.  Hamada N, Minamino T(9人中7番目). Emerging issues in radiogenic cataracts and cardiovascular disease. J Radiat Res, 55: 831-846, 2014. 査読有
8.  Yokoyama M, Minamino T(13人中13番目). Inhibition of endothelial p53 improves metabolic abnormalities related to dietary abesity. Cell Rep, 7: 1691-1703, 2014. 査読有
9.  Maida Y, Minamino T(12人中8番目). Involvement of TERT in heterochromatin maintenance. Mol Cell Biol,   34: 1576-1593, 2014. 査読有
10. Katsuumi G, Minamino T(23人中23番目). Efficacy of bepridil to prevent ventricular fibrillation in severe form of early repolarization syndrome. Int J Cardiol, 172: 519-522, 2014. 査読有
11. Suzuki T, Minamino T(9人中9番目). Inappropriate expression of hepcidin by liver congestion contributes to anemia and relative iron deficiency. J Card Fail, 20: 268-277, 2014. 査読有
12. Sato A, Minamino T(8人中8番目). Augmentation of the J wave by rapid pacing in a patient with vasospastic angina. Int J Cardiol, 172: e111-113, 2014. 査読有
13. Kashimura T, Minamino T(11人中11番目). Relative refractoriness of left ventricular contraction underlies human tachycardia-induced mechanical and electrical alternans. Pacing Clin Electrophysiol, 37: 197-206, 2014. 査読有
14. Shimizu I, Minamino T(4人中4番目). DNA damage response and metabolic disease. Cell Metab, 20: 967-977, 2014. 査読有

長井
1.  Hikosaka K, Nagai Y(11人中6番目). Deficiency of nicotinamide mononucleotide adenyltransferase 3 (nmnat3) causes hemolytic anemia by altering the glycolytic flow in mature erythrocytes. J Biol Chem, 289: 14796-14811, 2014. 査読有
2.  Honda H, Nagai Y(12人中2番目). Isoliquiritigenin is a potent inhibitor of NLRP3 inflammasome activation and diet-induced adipose tissue inflammation. J Leuko Biol, 96: 1087-1100, 2014. 査読有

三枝
1.  Hasegawa E, Mieda M(4人中4番目). Orexin neurons suppress narcolepsy via 2 distinct efferent pathways. J Clin Invest, 124: 604-616, 2014. 査読有

井上啓
1.   Inoue H. Molecular basis of brain-mediated regulation of hepatic glucose metabolism. Diabetol Int, 5:158-164, 2014. 査読有
2.   Haga S, Inoue H(11名中6番目). p62/SQSTM1 Plays a Protective Role in Oxidative Injury of Steatotic Liver in a Mouse Hepatectomy Model. Antioxid Redox Signal, 21: 2515-2530, 2014. 査読有
3.   Tanaka M, Inoue H(16名中12番目). Macrophage- inducibleC-typelectinunderliesobesity-induced adipose tissue fibrosis. Nat Commun, 5: 4982, 2014. 査読有
4.   Harada K, Inoue H(11名中7番目). Alteration of energy metabolism in the pathogenesis of bile duct lesions in primary biliary cirrhosis.
J Clin Pathol, 67: 396-402, 2014. 査読有
5.   Park JK, Inoue H(12名中10番目). ER stress-inducible ATF3 suppresses BMP2-induced ALP expression and activation in MC3T3-E1 cells. Biochem Biophys Res Commun, 443: 333-338, 2014. 査読有

藤本
1.  Ohsaki Y, Fujimoto T(3名中3番目). Open questions in lipid droplet biology. Chem Biol, 21: 86-96, 2014. 査読有

藤倉
1.  Sakai T, Fujikura J(15名中12番目). Leptin restores the insulinotropic effect of exenatide in a mouse model of type 2 diabetes with increased adiposity induced by streptozotocin and high-fat diet. Am J Physiol Endocrinol Metab, 307: E712-719, 2014. 査読有

錦見
1.  Wetzel-Strong SE, Nishikimi T(5名中4番目). Epicardial-derived adrenomedullin drives cardiac hyperplasia during embryogenesis. Dev Dyn, 243: 243-256, 2014. 査読有
2.  Nakagawa Y, Nishikimi T(17名中2番目). The effects of super-flux (high performance) dialyzer on plasma glycosylated pro-B-type natriuretic peptide (proBNP) and glycosylated N-Terminal proBNP in end-stage renal disease patients on dialysis. PLoS One, 9: e92314, 2014. 査読有

岩倉
1.  Mohan H, Iwakura H(6人中5番目). Nutrients Differentially Regulate Nucleobindin-2/Nesfatin-1 In Vitro in Cultured Stomach Ghrelinoma (MGN3-1) Cells and In Vivo in Male Mice. PLoS One, 9: e115102, 2014. 査読有
2.  Ariyasu H, Iwakura H(8人中3番目). Reduction in circulating ghrelin concentration after maturation does not affect food intake. Endocr J, 61: 1041-1052, 2014. 査読有
3.   Ariyasu H, Iwakura H(14人中2番目). Clinical effects of ghrelin on gastrointestinal involvement in patients with systemic sclerosis. Endocr J, 61: 735-742, 2014. 査読有

花田
1.   花田礼子,他: ニューロメジンU,ニューロメジンS. 日本臨床 増刊号:最新肥満症学 —基礎・臨床研究の最前線− 28: 903-906. 2014. 査読無

和田
1.  Tachibana H, Wada J(14人中11番目). Metallothionein deficiency exacerbates diabetic nephropathy in streptozotocin-induced diabetic mice. Am J Physiol Renal Physiol, 306: F105-F115, 2014. 査読有
2.  Ogawa D, Wada J(10人中3番目). Nuclear hormone receptor expression in mouse kidney and renal cell lines. PLoS ONE, 9: e85594, 2014. 査読有
3.  Watanabe M, Wada J(13人中12番目). Pemt deficiency ameliorates endoplasmic reticulum stress in diabetic nephropathy. PLoS ONE, 9: e92647, 2014. 査読有
4.  Miyoshi T, Wada J(11人中10番目). Effect of vildagliptin, a dipeptidyl peptidase 4 inhibitor, on cardiac hypertrophy induced by chronic beta-adrenergic stimulation in rats. Cardiovascular Diabetology, 13: 43, 2014. 査読有
5.  Terami N, Wada J(12人中5番目). Long-term treatment with the sodium glucose cotranspoter 2 inhibitor, dapagliflozin, ameliorates glucose homeostasis and diabetic nephropathy in db/db mice. PLoS ONE, 9: e100777, 2014. 査読有
6.  Ono T, Wada J(10人中7番目). Factors associated with remission and/or regression of microalbuminuria in type 2 diabetes mellitus. Acta Med Okayama, 68: 235-241, 2014. 査読有

浮穴
1.  Bessho Y, Ukena K(10人中10番目). Characterization of an avian histidine decarboxylase and localization of histaminergic neurons in the chicken brain. Neurosci Lett, 578: 106-110, 2014. 査読有
2.  Masuda K, Ukena K(9人中9番目).. Identification of neurotensin and LANT-6 and localization of mRNA encoding their precursor in the chicken brain. Zool Sci, 31: 353-359, 2014. 査読有
3.  Ukena K(5人中1番目)., Osugi T, Leprince J, Vaudry V, Tsutsui K. Molecular evolution of GPCRs: 26RFa/GPR103. J Mol Endocrinol, 52: T119-T131, 2014. 査読有
4. Ukena K(10人中1番目). Identification of a cDNA encoding a novel small secretory protein, neurosecretory protein GL, in the chicken hypothalamic infundibulum. Biochem Biophys Res Commun, 446: 298-303, 2014. 査読有

阪上
1.  Tsutsumi R, Sakaue H(12人中9番目). Sudachitin, a polymethoxylated flavone, improves glucose and lipid metabolism by increasing mitochondrial biogenesis in skeletal muscle. Nutr Metab, 11: 32, 2014. 査読有
2.  Mawatari K, Sakaue H(12人中11番目). Enhancement of endothelial function inhibits left atrial thrombi development in an animal model of spontaneous left atrial thrombosis. Circ J, 78: 2014, 1980-1988, 2014. 査読有
3.  Kihira Y, Sakaue H(14人中7番目). Deletion of hypoxia-inducible factor-1α in adipocytes enhances glucagon-like peptide-1 secretion and reduces adipose tissue inflammation. PLoS One, 9: e93856, 2014. 査読有
4.  Tsutsumi R, Sakaue H(10人中8番目). Albumin-normalized serum zinc: a clinically useful parameter for detecting taste impairment in patients undergoing dialysis. Nutr Res, 34: 11-16, 2014. 査読有

西尾
1.  Hayashi K, Nishio M(22人中19番目). Abrogation of protein phosphatase 6 promotes skin carcinogenesis induced by DMBA.Oncoqene, 8; 0, 2014. 査読有
2.  Nishio M(6人中1番目). The Hippo Signaling Pathway: A Candidate New Drug Target for Malignant Tumors. Innovative medicine: Basic Research and Development (editted by Nakao K), Springer 2014, in press
3.  Maehama T, Nishio M(5人中3番目). Nucleolar Stress Induces ubiquitination-independent proteasomal degradation of PICT1 protein.J Biol Chem, 289: 20802-20812, 2014. 査読有
4.  Okamura K, Nishio M(15人中5番目). PICT1 expression is a good prognostic factor in non-small cell lung cancer. Oncoscience, 1: 375-382, 2014. 査読有
5.  Dong Y, Nishio M(11人中9番目). The expression of PTEN in the development of mouse cochlear lateral wall.Neuroscience, 258: 263-269, 2014. 査読有

井田
1.  Veenstra JA, Ida T(2人中19番目). More Drosophila enteroendocrine peptides: Orcokinin B and the CCHamides 1 and 2. Cell Tisuue Res, 357: 607-621, 2014. 査読有
2.  Sato T, Ida T(6人中2番目). Nakamura Y, Shiimura Y, Kangawa K, Kojima M. Physiological roles of ghrelin in obesity. Obes Res Clin Pract, 8: 405-413, 2014. 査読有

伊達
1.  Akieda-Asai S, Date Y(4人中4番目). Role of the neural pathway from hindbrain to hypothalamus in interaction of GLP1 and leptin in rats. J Endocrinol, 220: 109-116, 2014. 査読有
2.  Akieda-Asai S, Date Y(3人中3番目). Coinjection of CCK and leptin reduces food intake via increased CART/TRH and reduced AMPK phosphorylation in the hypothalamus. Am J Physiol Endocrinol Metab, 306: E1284-E1291, 2014. 査読有
3.  Bae CR, Date Y(7人中7番目). Possible involvement of food texture in insulin resistance and energy metabolism in male rats. J Endocrinol, 222: 61-72, 2014. 査読有
4.  Bae CR, Date Y(6人中6番目). The short-term effects of soft pellets on lipogenesis and insulin sensitivity in rats. Prev Nutr Food Sci, 19: 164-169, 2014. 査読有

中島
1.  Olszak T, Nakajima A(22人中13番目). Protective mucosal immunity mediated by epithelial CD1d and IL-10.  Nature, 509: 497-502, 2014. 査読有
2.  Sakai E, Nakajima A(14人中13番目). Methylation epigenotypes and genetic features in colorectal laterally spreading tumors. Int J Cancer, 135: 1586-1595, 2014. 査読有
3.  Tanaka T, Nakajima A(26人中21番目). PPARβ/δ activation of CD300a controls intestinal immunity. Sci Rep, 4: 5412. 2014. 査読有
4.  Higurashi T, Nakajima A(14人中13番目). Conditional knockout of the leptin receptor in the colonic epithelium revealed the local effects of leptin receptor signaling in the progression of colonic tumors in mice. Carcinogenesis, 35: 2134-2141, 2014. 査読有
5.  Yamada E, Nakajima A(13人中13番目). Association Between the Location of Diverticular Disease and the Irritable Bowel Syndrome: A Multicenter Study in Japan. Am J Gastroenterol, 109: 1900-1905, 2014. 査読有
6.  Imajo K, Nakajima A(18人中17番目). LDL-Migration Index (LDL-MI), an Indicator of Small Dense Low-Density Lipoprotein (sdLDL), Is Higher in Non-Alcoholic Steatohepatitis than in Non-Alcoholic Fatty Liver: A Multicenter Cross-Sectional Study. PLoS One, 9: e115403, 2014. 査読有
7.  Imajo K, Nakajima A(17人中17番目). Oral choline tolerance test as a novel noninvasive method for predicting nonalcoholic steatohepatitis. J Gastroenterol, 49: 295-304, 2014. 査読有

河野
1.  Williams KW, Kohno D(20人中13番目). Xbp1s in Pomc neurons connects ER stress with energy balance and glucose homeostasis. Cell Metab, 20: 471-482, 2014. 査読有

船戸
1.  Wang Z, Funato H(9人中6番目). Orexin/Hypocretin Activates mTOR Complex 1 (mTORC1) via an Erk/Akt-independent and Calcium-stimulated Lysosome v-ATPase Pathway. J Biol Chem, 289: 31950-31959, 2014.査読有
2.  Takase K, Funato H(6人中6番目). Meta-analysis of melanin-concentrating hormone signaling-deficient mice on behavioral and metabolic phenotypes. PLoS One, 9: e99961, 2014.査読有
3.  Oda S, Funato H(7人中2番目). A subset of thalamocortical projections to the retrosplenial cortex possesses two vesicular glutamate transporter isoforms, VGluT1 and VGluT2, in axon terminals as well as somata. Journal of Comparative Neurology, 522: 2089-2106, 2014.査読有

高田
1.  Oka A, Takada T(4人中2番目). Evolutionarily diverged regulation of X-chromosomal genes as a primal event in mouse reproductive isolation. PLoS Genet, 10: e1004301, 2014. 査読有
2.  Dou X, Takada T(5人中4番目). Influence analysis in quantitative trait loci detection. Biom J, 56: 697-719, 2014. 査読有

土田
1.  Hitachi K, Tsuchida K(3人中3番目). Myostatin signaling regulates Akt activity via the regulation of miR-486 expression. Int J Biochem Cell Bio, 47: 93-103, 2014. 査読有
2.  Uezumi A, Tsuchida K(3人中3番目). Role for nonmyogenic mesenchymal progenitors in pathogenesis and regeneration of skeletal muscle. Frontiers in Physiology, 5: Article 68,1-11, 2014. 査読有
3.  Hitachi K, Tsuchida K(2人中2番目). Role of microRNAs in muscle hypertrophy. Frontiers in Physiology, 408: 1-7, 2014. 査読有
4.  Uezumi A, Tsuchida K(8人中8番目). Identification and characterization of PDGFRα mesenchymal progenitors in human skeletal muscle. Cell Death Disease, 5: e1186, 2014. 査読有
5.  Tsuchida K. Myokines and signal crosstalk between skeletal muscle and adipose tissue. Austin J Endo Metab, 1: 2, 2014. 査読有

[平成23年度~平成24年度]
中川
1.  Nakagawa Y(31人中1番目). Hepatic CREB3L3 controls whole-body energy homeostasis and improves obesity and diabetes. Endocrinology, 155: 4706-4719, 2014. 査読有

北村
1.  Sasaki T, Kitamura T(21人中1番目). Hypothalamic Sirt1 prevents age-associated weight gain by improving leptin sensitivity in mice. Diabetologia, 57: 819-831, 2014. 査読有
2.  Susanti V-Y, Kitamura T(10人中10番目). Sirt1 reverses the obesity by insulin-resistant constitutively-nuclear FoxO1 in POMC neurons of male mice. Obesity, 10: 2115-2119, 2014. 査読有

千田
1.  Kameda H, Chida D(8人中7番目). Expression and regulation of neuromedin B in pituitary corticotrophs of male melanocortin 2 receptor-deficient mice. Endocrinology, 155: 2492-2499, 2014. 査読有
2.  Nakamoto A, Chida D(12人中6番目). Proteomics-based identification of novel proteins in temporal tendons of patients with masticatory muscle tendon-aponeurosis hyperplasia. Int J Oral Maxillofac Surg, 43: 113-119, 2014. 査読有


【受賞】
片桐秀樹/東北大学大学院医学系研究科・糖尿病代謝内科学分野・教授
平成26年度文部科学大臣表彰 科学技術賞(研究部門)(平成26年4月15日)
「臓器間代謝情報ネットワーク機構発見の研究」

井上 啓/金沢大学・新学術創成研究機構・教授
平成26年度日本医師会 医学研究奨励賞(平成26年11月1日)
「中枢神経・肝臓クロストークの分子メカニズムの解明」

井上 啓/金沢大学・新学術創成研究機構・教授
第57回日本糖尿病学会年次学術集会 リリー賞(平成26年5月22日)
「中枢神経による肝糖代謝制御の分子基盤の解明」

菅波孝祥/東京医科歯科大学臓器代謝ネットワーク講座・特任教授
日本心血管内分泌学会・第18回高峰譲吉研究奨励賞(平成26年11月21日)
「メタボリックシンドロームにおける脂肪組織炎症の分子機構と医学応用」

菅波孝祥/東京医科歯科大学臓器代謝ネットワーク講座・特任教授
臨床薬理研究振興財団・第7回研究大賞(平成26年11月11日)
「新しい疾患モデル動物を用いた非アルコール性脂肪性肝炎の治療戦略の開発に関する研究」


■2013
【業績論文】
研究代表者、研究分担者は一重下線、corresponding authorは左に*印で明示
≪計画研究≫
寒川
1.   Tsuchimochi W, Kangawa K(7人中6番目). Ghrelin prevents the development of experimental diabetic neuropathy in rodents. Eur J Pharmacol, 702: 187-193, 2013. 査読有
2.   Akieda-Asai S, Miyazato M, Kangawa K(3人中2,3番目). Involvement of guanylin and GC-C in rat mesenteric macrophages in resistance to a high-fat diet. J Lipid Res, 54: 85-96, 2013. 査読有
3.   Kaiya H, Kangawa K, Miyazato M(3人中2,3番目). What is the general action of ghrelin for vertebrates? - comparisons of ghrelin's effects across vertebrates. Gen Comp Endocrinol, 181: 187-191, 2013. 査読有
4.   Inoue Y, Kangawa K(7人中6番目). Central and peripheral des-acyl ghrelin regulates body temperature in rats. Biochem Biophys Res Commun, 430: 278-283, 2013. 査読有
5.   Miyata H, Kangawa K(5人中4番目). Effect of rikkunshito, a Japanese herbal medicine, on gastrointestinal symptoms and ghrelin levels in gastric cancer patients after gastrectomy. Gastric Cancer, 16: 167-174, 2013. 査読有
6.   Soeki T, Kishimoto I, Kangawa K(21人中22番目). Ghrelin protects the heart against ischemia-induced arrhythmias by preserving connexin-43 protein. Heart Vessels, 20: 1213-1223, 2013. 査読有
7.   Mao Y, Kishimoto I, Miyazato M, Kangawa K(8人中8番目). Ghrelin prevents incidence of malignant arrhythmia after acute myocardial infarction through vagal afferent nerves. Endocrinology, 154: 1854-1863, 2013. 査読有
8.   Bando M, Kangawa K(9人中8番目). Overexpression of intraislet ghrelin enhances β-cell proliferation after streptozotocin-induced β-cell injury in mice. Am J Physiol Endocrinol Metab, 305: E140-E148, 2013. 査読有
9.   Miki K, Kangawa K(11人中11番目). Effects of ghrelin treatment on exercise capacity in underweight COPD patients: a substudy of a multicenter, randomized, double-blind, placebo-controlled trial of ghrelin treatment. BMC Pulm Med, 13: 37, 2013. 査読有
10.  Nishi Y, Kangawa K(9人中8番目). Changes in Subcellular Distribution of n-Octanoyl or n-Decanoyl Ghrelin in Ghrelin-Producing Cells. Front Endocrinol (Lausanne), 4: 84, 2013. 査読有
11.  Mao Y, Kishimoto I, Miyazato M, Kangawa K(9人中9番目). Hexarelin treatment in male ghrelin knockout mice after myocardial infarction. Endocrinology, 154: 3847-3854, 2013. 査読有
12.  Kaiya H, Kangawa K(7人中6番目), Miyazato M: Determination of Ghrelin Structure in the Barfin Flounder (Verasper moseri) and Involvement of Ingested Fatty Acids in Ghrelin Acylation. Front Endocrinol (Lausanne), 4: 117, 2013 査読有
13.  Fukumori R, Kangawa K(11人中8番目). Ingestion of medium chain fatty acids by lactating dairy cows increases concentrations of plasma ghrelin. Domest Anim Endocrinol, 45: 216-223, 2013. 査読有

児島
1.  Fukumori R, Kojima M(8人中5番目). Effects of intravenous ghrelin injection on plasma growth hormone, insulin and glucose concentrations in calves at weaning. Anim Sci J, 84: 310-5, 2013. 査読有
2.  Li E, Kojima M(8人中7番目). Ghrelin directly stimulates adult hippocampal neurogenesis: implications for learning and memory. Endocr J, 60: 781-789, 2013. 査読有
3.  Kojima M(2人中1番目). Ghrelin discovery: a decade after. Endocr Dev, 25: 1-4,2013. 査読有
4.  Nakamura Y, Sato T, Kojima M(5人中5番目). FABP3 and brown adipocyte- characteristic mitochondrial fatty acid oxidation enzymes are induced in beige cells in a different pathway from UCP1. Biochem Biophys Res Commun, 441: 42-46, 2013. 査読有

塩田
1.  Furutani N, Kageyama H, Shioda S (8人中7番目). Neurotensin co-expressed in orexin-producing neurons in the lateral hypothalamus plays an important role in regulation of sleep/wakefulness States. PLoS One, 8: e62391, 2013. 査読有
2.  Toda C, Kageyama H, Shioda S (13人中12番目). Extracellular Signal-Regulated Kinase in the Ventromedial Hypothalamus Mediates Leptin-Induced Glucose Uptake in Red-Type Skeletal Muscle. Diabetes, 62: 2295-2307, 2013. 査読有
3.  Kageyama H, Kageyama H, Shioda S (10人中10番目).Galanin-like peptide (GALP) facilitates thermogenesis via synthesis of prostaglandin E2 by astrocytes in the periventricular zone of the third ventricle. J Mol Neurosci, 50 : 443-452, 2013. 査読有
4.  塩田清二・竹ノ谷文子・影山晴秋、視床下部弓状核、腹内側核の摂食調節ニューロンの機能形態. 肥満研究, 19: 29-38, 2013. 査読有
5.  Ito K, Kageyama H, Hirako S, Kageyama H, Ogawa T, Shioda S (7人中7番目). Interactive effect of galanin-like peptide(GALP) and spontaneous exercise on energy metabolism. Peptides, 49: 109-116, 2013. 査読有
6.  Izumida Y, Shioda S (21人中14番目). Glycogen shortage during fasting triggers liver-brain-adipose neurocircuitry to facilitate fat utilization. Nat Commum, 4: 2316, 2013. 査読有

片桐
1.  Saito T, Katagiri H(14人中14番目). Importance of endothelial NF-kB signaling in vascular remodeling and aortic aneurysm formation. Cardiovasc Res, 97: 106-14, 2013. 査読有
2.  Izumida Y, Katagiri H(22人中18番目). Glycogen shortage during fasting triggers liver-brain-adipose neurocircuitry to facilitate fat utilization. Nat Commun, 4: 2316, 2013. 査読有
3.  Sakata N, Katagiri H(26人中14番目). Clinical Experiences in the Treatment of Pancreatic Arteriovenous Malformation by Total Pancreatectomy With Islet Autotransplantation. Transplantation. 96: e38-e40 2013. 査読有
4.  Takagi M, Katagiri H(14人中13番目). Cognitive dysfunction associated with anti-glutamic acid decarboxylase autoimmunity: a case-control study. BMC Neurology, 13:76, 2013. 査読有
5.  Kondo K, Katagiri H(10人中10番目). Bach1 deficiency protects pancreatic β-cells from oxidative stress injury. Am J Physiol Endocrinol Metab, 305: E641-E648, 2013. 査読有

箕越
1. Rodriguez-Araujo G, Minokoshi Y(11人中6番目). Alpha-synuclein elicits glucose uptake and utilization in adipocytes through the Gab1/PI3K/Akt transduction pathway. Cell Mol Life Sci, 70: 1123-1133, 2013. 査読有
2. Toda C, Minokoshi Y(13人中13番目). Extracellular signal-regulated kinase in the ventromedial hypothalamus mediates leptin-induced glucose uptake in red-type skeletal muscle. Diabetes, 62: 2295-2307, 2013. 査読有


1. 脇 裕典, 山内敏正, 門脇 孝. 糖尿病と遺伝子 4.糖尿病とエピゲノム 糖尿病, 57 (2) 2014年2月 p91-93. 査読無
2.  脇 裕典, 山内 敏正, 門脇 孝. エピゲノムと肥満症 医学のあゆみ (第5土曜特集 肥満の医学 : 臨床と研究の最先端), 250 (9) 2014年8月 p797-801. 査読無
3.  中村正裕, 脇 裕典. IIIプロトコール エピゲノム C.クロマチンアクセシビリティ解析 2.オープンクロマチンを同定するFAIRE-seq 実験医学別冊 次世代シークエンス解析スタンダード, 2014年9月 p195-203. 査読無

船橋
1.  Nakatsuji H, Kishida K, Funahashi T(5人中2,4番目). Senri Study II Group: Three-month treatment with pioglitazone reduces circulating C1q-binding adiponectin complex to total-adiponectin ratio, without changes in body mass index, in people with type 2 diabetes. Diabetes Res Clin Pract, 99: e14-17, 2013. 査読有
2.  Nakatsuji H, Kishida K, Funahashi T(9人中3,8番目). Binding of adiponectin and C1q in human serum, and clinical significance of the measurement of C1q-adiponectin / total adiponectin ratio. Metabolism, 62: 109-120, 2013. 査読有
3.  Hirata A, Kishida K, Funahashi T(6人中2,5番目). Correlation between serum C1q-adiponectin/total adiponectin ratio and polyvascular lesions detected by vascular ultrasonography in Japanese type 2 diabetics. Metabolism, 62: 376-385, 2013. 査読有
4.  Hirata A, Kishida K, Funahashi T(6人中2,5番目). High serum C1q-adiponectin/total adiponectin ratio correlates with coronary artery disease in Japanese type 2 diabetics. Metabolism, 62: 578-585, 2013.
5.  Maeda N, Funahashi T(3人中1,2番目). Cardiovascular-metabolic impact of adiponectin and aquaporin. Endocr J, 60: 251-259, 2013. 査読有
6.  Kishida K, Funahashi T(7人中1,6番目). Serum C1q- binding adiponectin in maintenance hemodialysis patients. BMC Nephrol, 14: 50, 2013. 査読有
7.  Mori T, Maeda N, Nishizawa H, Funahashi T(12人中2,9,11番目). A novel role for adipose ephrin-B1 in inflammatory response. PLoS One. 8: e76199,2013. 査読有

中里
1.  Tsuchimochi W, Yamaguchi H, Toshinai K, Nakazato M(7人中7番目). Ghrelin prevents the development of experimental diabetic neuropathy in rodents. Eur J Pharmacol, 702: 187-193, 2013.
2.  Miyoshi K, Nakazato M(12人中12番目). Epithelial Pten controls acute lung injury and fibrosis by regulating alveolar epithelial cell integrity. Am J Respir Crit Care Med, 187: 262-275, 2013. 査読有
3.  Yano Y, Ueno M, Nakazato M(11人中4,9番目). Shimada K, Kario K: Nighttime blood pressure, nighttime glucose values, and target-organ damages in treated type 2 diabetes patients. Atherosclerosis, 227: 135-139, 2013. 査読有
4.  Matsumoto N, Ueno M, Nakazato M(8人中6,8番目). A possible role of galectin-9 in the pulmonary fibrosis of patients with interstitial pneumonia. Lung, 191: 191-198, 2013. 査読有
5.  Koshinaka K, Nakazato M(6人中5番目). Elevation of muscle temperature stimulates muscle glucose uptake in vivo and in vitro. J Physiol Sci, 63: 409-418, 2013. 査読有

清水
1.  Katano-Toki A, Shimizu H(15人中11番目). THRAP3 interacts with HELZ2 and plays a novel role in adipocyte differentiation. Mol Endocrinology, 27: 769-780, 2013. 査読有
2.  Osaki A, Shimizu H(2人中1,2番目). Peripheral administration of nesfatin-1 increases blood pressure in mice. Hypertens Res, 37: 185-186, 2013. 査読有

細田
1.  Yamada-Goto N, Hosoda K(12人中11番目). Intracerebroventricular administration of C-type natriuretic peptide suppresses food intake via activation of the melanocortin system in mice. Diabetes, 62: 1500-1504, 2013. 査読有
2.  Ida M, Hosoda K(10人中9番目). Early Changes of Abdominal Adiposity Detected with Weekly Dual Bioelectrical Impedance Analysis During Calorie Restriction. Obesity, 21: E350-E353, 2013. 査読有
3.  Noguchi M, Hosoda K(13人中2番目). In vitro characterization and engraftment of adipocytes derived from human induced pluripotent stem cells and embryonic stem cells. Stem Cells Dev, 22: 2895-2905, 2013. 査読有
4.  Fujikura J, Hosoda K(3人中2番目). Cell transplantation therapy for diabetes mellitus: endocrine pancreas and adipocyte [Review]. Endocr J, 60: 697-708, 2013. 査読有
5.  Chew SH, Hosoda K(13人中10番目). Cancer-promoting role of adipocytes in asbestos-induced mesothelial carcinogenesis through dysregulated adipocytokine production. Carcinogenesis, 35: 164-172, 2013. 査読有
6.  Aizawa-Abe M, Tomita T, Hosoda K(14人中6,12番目). Generation of leptin-deficient Lepmkyo/Lepmkyo rats and identification of leptin-responsive genes in the liver. Physiol Genomics, 45: 786-793, 2013. 査読有

≪公募研究≫
[平成25年度~平成26年度]
島野
1.  Fujimoto Y, Shimano H(19人中19番目).TFE3 Controls Lipid Metabolism in Adipose Tissue of Male Mice by Suppressing Lipolysis and Thermogenesis. Endocrinology, 154: 3577-3588, 2013. 査読有
2.  Hirasawa R, Shimano H(12人中9番目). Quality and accuracy of Internet information concerning a healthy diet. Int J Food Sci Nutr, 64: 1007-1013, 2013. 査読有
3.  Izumida Y, Shimano H(21人中21番目). Glycogen shortage during fasting triggers liver-brain-adipose neurocircuitry to facilitate fat utilization. Nat Commun, 4: 2316. , 2013. 査読有
4.  Kodama S, Shimano H(12人中9番目). Use of high-normal levels of hemoglobin A1C and fasting plasma glucose for diabetes screening and prediction - A meta-analysis. Diabetes Metab Res Rev, 29: 680-692, 2013. 査読有
5.  Sunaga H, Shimano H(11人中9番目). Deranged fatty acid composition causes pulmonary fibrosis in Elovl6-deficient mice. Nat Commun, 4: 2563, 2013. 査読有
6.  Wada T, Shimano H(13人中11番目). Eplerenone ameliorates the phenotypes of metabolic syndrome with NASH in liver-specific SREBP-1c Tg mice fed high-fat and high-fructose diet. Am J Physiol Endocrinol Metab, 305: E1415-1425, 2013. 査読有
7.  Heianza Y, Shimano H(9人中7番目). Effect of Postmenopausal Status and Age at Menopause on Type 2 Diabetes and Prediabetes in Japanese Individuals: Toranomon Hospital Health Management Center Study 17 (TOPICS 17). Diabetes Care, 36: 4007-4014, 2013. 査読有
8.   Horie T, Shimano H(14人中12番目)., Matsumura S, Inoue K, Marusawa H, Nakamura T, Hasegawa K, Kume N, Yokode M, Kita T, Kimura T, Ono K. MicroRNA-33 regulates sterol regulatory element-binding protein 1 expression in mice. Nat Commun, 4: 2883, 2013. 査読有
9.   Fujihara K, Shimano H(14人中12番目). The Relationship between Diabetic Neuropathy and Sleep Apnea Syndrome: A Meta-Analysis. Sleep Disord, 150371, 2013. 査読有
10.  Matsuzaka T, Shimano H(14人中12番目). Insulin-dependent and -independent regulation of sterol regulatory element-binding protein-1c. Journal of Diabetes Investigation, 4: 411-412, 2013. 査読有


1.  Fujimoto Y, Izumi T(19人中15番目). TFE3 controls lipid metabolism in adipose tissue of male mice by suppressing lipolysis and thermogenesis. Endocrinology, 154, 3577-3588, 2013.査読有
2.  Yogosawa S, Izumi T(2人中2番目). Roles of activin receptor-like kinase 7 signaling and its target, peroxisome proliferator-activated receptor γ, in lean and obese adipocytes. Adipocyte, 2, 246-250, 2013. 査読有

菅波
1.  Itoh M, *Suganami T(16人中3番目). Hepatic crown-like structure: a unique histological feature in non-alcoholic steatohepatitis in mice and humans. PLoS ONE, 8: e82163, 2013. 査読有

南野
1.  Shimizu I, *Minamino T(4人中4番目). Adipose tissue inflammation in diabetes and heart failure. Microbes and Infection,15: 11-17, 2013. 査読有
2.  Kawashima H, Minamino T(9人中7番目). Tumor suppresser p53 inhibits systemic autoimmune diseases by inducing regulatory T cells. J Immunol,191: 3614-3623, 2013. 査読有
3.  Ozasa Y, Minamino T(15人中12番目). Notch activation mediates angiotensin II-induced vascular remodeling by promoting the proliferation and migration of vascular smooth muscle cell. Hypertens Res,36: 859-865, 2013. 査読有
4.  Shimizu I, *Minamino T(7人中7番目). Semaphorin-induced inflammation contributes to insulin resistance in dietary obesity. Cell Metab,18: 491-504, 2013. 査読有
5.  Bezzina CR. Minamino T(62人中28番目). Common variants at the SCN5A/SCN10A and HEY2 loci predispose to Brugada syndrome, a rare disease with high risk of sudden cardiac death. Nat Genet, 45: 1044-1049, 2013. 査読有
6.  Nojima A, *Minamino T(10人中10番目). Haploinsufficiency of Akt1 prolongs the lifespan of mice. PLoS One, 8: e69178, 2013. 査読有
7.  Watanabe H, *Minamino T(2人中2番目). Role of mutations in L-type calcium channel genes in Brugada syndrome, early repolarization syndrome, and idiopathic ventricular fibrillation associated with right bundle branch block. Circ J, 77: 1689-90, 2013. 査読有
8.  Sato A, *Minamino T(5人中5番目). Malfunction of cardiac resynchronization therapy due to subsequent fracture of the ring and tip conductors of a co-radial left ventricular bipolar lead. Intern Med, 52: 1189-93, 2013. 査読有
9.  Watanabe T, *Minamino T(16人中16番目). A mutant mRNA expression in an endomyocardial biopsy sample obtained from a patient with a cardiac variant of Fabry disease caused by a novel acceptor splice site mutation in the invariant AG of intron 5 of the α-galactosidase A gene. Intern Med, 52: 777-80, 2013. 査読有
10. Watanabe H, Minamino T(16人中12番目). Effects of flecainide on exercise-induced ventricular arrhythmias and recurrences in genotype-negative patients with catecholaminergic polymorphic ventricular tachycardia. Heart Rhythm, 10: 542-7, 2013. 査読有
11. Watanabe H, Minamino T(10人中9番目). SCN5A mutation associated with ventricular fibrillation, early repolarization, and concealed myocardial abnormalities. Int J Cardiol, 165: e21-3, 2013. 査読有

長井
1.  Fujisaka S, Nagai Y(11人中9番目). Adipose tissue hypoxia induces inflammatory M1 polarity of macrophages in HIF-1 alpha-dependent and HIF-1 alpha-independent manner in obese mice. Diabetologia, 56: 1403-1412, 2013. 査読有
2.  Nagai Y(3人中1番目). The TLR family protein RP105/MD-1 complex: a new player in obesity and adipose tissue inflammation. Adipocyte, 2 : 61-66, 2013. 査読有
3.  Watanabe Y, Nagai Y(3人中2番目). Activation and regulation of the pattern recognition receptors in obesity-induced adipose tissue inflammation and insulin resistance. Nutrients, 5: 3757-3778, 2013. 査読有

三枝
1.  Furutani N, Mieda M(8人中5番目). Neurotensin co-expressed in orexin-producing neurons in the lateral hypothalamus plays an important role in regulation of sleep/wakefulness states. PLoS One, 8: e62391, 2013. 査読有
2.  Soya S, Mieda M(8人中7番目). Orexin Receptor-1 in the Locus Coeruleus plays an Important Role in Cue-Dependent Fear Memory Consolidation. J Neurosci, 33: 14549-14557, 2013. 査読有
3.  Saito YC, Mieda M(8人中6番目). GABAergic neurons in the preoptic area send direct inhibitory projections to orexin neurons. Front Neural Circuits, 7: 192, 2013. 査読有

井上啓
1.  Kimura K, *Inoue H(18名中18番目). Histidine augments the suppression of hepatic glucose production by central insulin action. Diabetes, 62(7):2266-77, 2013. 査読有
2.  Kimura I, Inoue H(15名中14番目). The gut microbiota suppresses insulin-mediated fat accumulation via the short-chain fatty acid receptor GPR43. Nat Commun, 4:1829, 2013. 査読有
3.  Lee YS, Inoue H(18名中11番目). Hypothalamic ATF3 is involved in regulating glucose and energy metabolism in mice. Diabetologia, 56(6):1383-93, 2013. 査読有
4.  Asahara S, Inoue H(20名中16番目). Ras-related C3 botulinum toxin substrate 1 (RAC1) regulates glucose-stimulated insulin secretion via modulation of F-actin. Diabetologia, 56(5):1088-97, 2013. 査読有

藤倉
1.  Noguchi M, Fujikura J(13名中11番目). In vitro characterization and engraftment of adipocytes derived from human induced pluripotent stem cells and embryonic stem cells. Stem Cells Dev, 22: 2895-2905, 2013. 査読有
2.  Fujikura J(3名中1番目). Cell transplantation therapy for diabetes mellitus: endocrine pancreas and adipocyte. Endocr J, 60: 697-708, 2013. 査読有
3.  Ida M, Fujikura J(10名中6番目). Early changes of abdominal adiposity detected with weekly dual bioelectrical impedance analysis during calorie restriction. Obesity (Silver Spring), 21: E350-353, 2013. 査読有

錦見
1.  Nishikimi T, (5名中1番目). Adrenomedullin in cardiovascular disease: a useful biomarker, its pathological roles and therapeutic application. Curr Protein Pept Sci, 14: 256-267, 2013. 査読有

岩倉
1.   Karra E, Iwakura H (23人中11番目). A link between FTO, ghrelin, and impaired brain food-cue responsivity. J Clin Invest, 123:3539-51, 2013. 査読有

花田
1.  花田礼子:RANKL/RANKシステム-最近の知見 Annual Rev. 2013 糖尿病・代謝・内分泌:162-170, 2013. 査読無
3.  Hanada T, Hanada R, Penninger JM*(24人中7番目). The RNA kinase CLP1 links tRNA metabolism to progressive motor neuron loss. Nature, 495: 474-480, 2013.査読有

和田
1.  Inoue K, Wada J(15人中2番目). Urinary fetuin-A is a novel marker for diabetic neohropathy in type 2 diabetes identified by lectin microarray. PLoS ONE, 8: e77118, 2013. 査読有
2.  Terami T, Wada J(10人中2番目). Urinary angiotensinogen is a marker for tubular injuries in patients with type 2 diabetes. Int J Nephrol Renovasc Dis, 6, 233-240, 2013. 査読有
3.  Nakayama K, Wada J(9人中8番目). Long-term effect of cinacalcet hydrochloride on abdominal aortic calcification in patients on hemodialysis with secondary hyperparathyroidism. Int J Nephrol Renovasc Dis, 7,25-33, 2013 . 査読有

阪上
1.  Jambaldorj B, Sakaue H(17人中13番目). Cysteine string protein 1 (CSP1) modulates insulin sensitivity by attenuating glucose transporter 4 (GLUT4) vesicle docking with the plasma membrane. J Med Invest, 60: 197-204, 2013. 査読有

中島
1.  Ohkubo H, Nakajima A(15人中14番目). Assessment of small bowel motility in patients with chronic intestinal pseudo-obstruction using cine-MRI. Am J Gastroenterol, 108(7): 1130-1139, 2013. 査読有
2.  Ogawa Y, Wada J(15人中15番目). Soluble CD14 levels reflect liver inflammation in patients with nonalcoholic steatohepatitis. PLoS One, 8(6): e65211, 2013. 査読有

亀井
1.  Takahashi M, Kamei Y(8人中2番目). Analysis of DNA methylation change induced by Dnmt3b in mouse hepatocytes. Biochem Biophys Res Commun, 434: 873-878, 2013. 査読有

河野
1.  Iwasaki Y, Kohno D(11人中3番目). Insulin Activates Vagal Afferent Neurons Including those Innervating Pancreas via Insulin Cascade and Ca2+ Influx: Its Dysfunction in IRS2-KO Mice with Hyperphagic Obesity. PLoS One, 8: e67198, 2013. 査読有

高田
1.  Takada T(16人中1番目), et al. The ancestor of extant Japanese fancy mice contributed to the mosaic genomes of classical inbred strains. Genome Res, 23: 1329-1338, 2013. 査読有

土田
1.  Tsuchida K(4人中1番目). Origin and therapeutic strategies for ectopic bone formation in skeletal muscle. Human Genet Embryol, 3: 110 , 2013. 査読有
2.  Ikeda D, Tsuchida K(4人中3番目). iTRAQ-based proteomics reveals novel biomarkers of osteoarthritis. Biomarkers, 18: 565-572, 2013. 査読有

[平成23年度~平成24年度]
中川
1.   Fujimoto Y, Nakagawa Y(19人中2番目). TFE3 controls lipid metabolism in adipose tissue of male mice by suppressing lipolysis and thermogenesis. Endocrinology, 154: 3577-3588, 2013. 査読有
2.   Naka A, Nakagawa Y(16人中3番目). TFE3 inhibits myoblast differentiation in C2C12 cells via down-regulating gene expression of myogenin. Biochem Biophys Res Commun, 430: 664-669, 2013. 査読有
3.   Izumida Y, Nakagawa Y(21人中10番目). Glycogen shortage during fasting triggers liver-brain-adipose neurocircuitry to facilitate fat utilization. Nature Communications, 4: 2316, 2013. 査読有

井上順
1.  Maruyama R, Inoue J(5人中4番目). ATF6α stimulates cholesterogenic gene expression and de novo cholesterol synthesis. Biosci Biotechnol Biochem, 77: 1734-1738, 2013. 査読有
2.  Takahashi Y, Inoue J(9人中8番目). Perilipin-mediated lipid droplet formation in adipocytes promotes sterol regulatory element-binding protein-1 processing and triacylglyceride accumulation. PLoS One, 8: e64605, 2013.  査読有
3.  Shimizu M, Inoue J(5人中4番目). FGF19 (fibroblast growth factor 19) as a novel target gene for activating transcription factor 4 in response to endoplasmic reticulum stress. Biochem J, 450: 221-229, 2013. 査読有
4.  Yashiro T, Inoue J(5人中4番目). 5-Aminoimidazole-4-carboxamide ribonucleoside stabilizes low density lipoprotein receptor mRNA in hepatocytes via ERK-dependent HuR binding to an AU-rich element. Atherosclerosis, 226: 95-101, 2013. 査読有

亀井
1.  Takahashi M, Kamei Y(8人中2番目). Analysis of DNA methylation change induced by Dnmt3b in mouse hepatocytes. Biochem Biophys Res Commun, 434: 873-878, 2013. 査読有

井上啓
1.  Kimura K, *Inoue H(18人中18番目). Histidine augments the suppression of hepatic glucose production by central insulin action. Diabetes, 62: 2266-2277, 2013. 査読有
2.  Kimura I, Inoue H(15人中14番目). Gut microbiota suppresses insulin-mediated fat accumulation via the short-chain fatty acid receptor GPR43. Nat Commun, 4: 1829, 2013. 査読有
3.  Lee YS, Inoue H(18人中11人目). Hypothalamic ATF3 is involved in regulating glucose and energy metabolism in mice. Diabetologia, 56: 1383-1393, 2013. 査読有
4.  Asahara S, Inoue H(20人中15番目). Ras-related C3 botulinum toxin substrate 1 (RAC1) regulates glucose-stimulated insulin secretion via modulation of F-actin. Diabetologia, 56-1088-1097,2013. 査読有

岩倉
1.  Bando M, Iwakura H(9人中2番目). Overexpression of intra-islet ghrelin enhances β-cell proliferation after streptozotocin-induced β-cell injury in mice. Am J Physiol Endocrinol Metab, 305: E140-148, 2013. 査読有
2.  Janssen S, Iwakura H(5人中3番目). Sensing of fatty acids for octanoylation of ghrelin involves a gustatory G-protein. PLoS ONE, 7: e40168, 2013. 査読有

錦見
1.  Nishikimi T(17人中1番目), et al. Direct immunochemiluminescent assay for proBNP and total BNP in human plasma proBNP and total BNP levels in normal and heart failure. PLoS ONE, 8: e53233, 2013. 査読有
2.  Nishikimi T(6人中1番目), et al. Complexity of molecular forms of B-type natriuretic peptide in heart failure. Heart, 99: 677-679, 2013. 査読有

中畑
1.  Bellet MM, Nakahata Y(12人中2番目). Pharmacological modulation of circadian rhythms by synthetic activators of the deacetylase SIRT1. Proc Natl Acad Sci U S A, 110:3333-3338, 2013. 査読有

和田
1. Murakami K, Wada J(9人中2番目). The effects of telmisartan treatment on the abdominal fat depot in patients with metabolic syndrome and essential hypertension: Abdominal fat Depot Intervention Program of Okayama (ADIPO). Diab Vasc Dis Res, 10: 93-96, 2013. 査読有
2.  Nakatsuka A, Wada J(19人中2番目). Vaspin inhibits apoptosis of endothelial cells as a ligand for cell-surface GRP78/VDAC complex. Circ Res, 112: 771-7810, 2013. 査読有
3.  Kurose Y, Wada J(14人中2番目). Serum galectin-9 levels are elevated in the patients with type 2 diabetes and chronic kidney disease. BMC Nephrol, 14: 23, 2013. 査読有

浮穴
1.  Ukena K(6人中1番目) , et al. Identification, localization and function of a novel neuropeptide, 26RFa, and its cognate receptor, GPR103, in the avian hypothalamus. Gen Comp Endocrinol, 190: 42-46, 2013. 査読有

斉藤
1.  Mizusawa K, Saito Y(5人中4番目). Interrelation between melanocyte-stimulating hormone and melanin-concentrating hormone in physiological body color change: roles emerging from barfin flounder Verasper moseri. General and Comparative Endocrinology, 181, 229-234, 2013. 査読有
2.  Nagata A, Saito Y(6人中6番目). Characterization of ciliary targeting sequence of rat melanin-concentrating hormone receptor 1. General Comp Endocri, 188: 159-165, 2013. 査読有

志内
1.  Rodriguez-Araujo G, Shiuchi T(11人中5番目). Alpha-synuclein elicits glucose uptake and utilization in adipocytes through the Gab1/PI3K/Akt transduction pathway. Cell Mol Life Sci, 70: 1123-1133, 2013. 査読有
2.  Toda C, Shiuchi T(13人中2番目). Extracellular Signal-Regulated Kinase in the Ventromedial Hypothalamus Mediates Leptin-Induced Glucose Uptake in Red-Type Skeletal Muscle. Diabetes, 62: 2295-2307, 2013. 査読有

伊達
1.  Akieda-Asai S, Date Y(17人中17番目). Involvement of guanylin and GC-C in rat mesenteric macrophages in resistance to high-fat diet. J Lipid Res, 54: 85-96, 2013. 査読有

前島
1.  Sedbazar U, Maejima Y(4人中2番目). Paraventricular NUCB2/nesfatin-1 rises  in synchrony with feeding suppression during early light phase in rats. Biochem  Biophys Res Commun, 434: 434-438, 2013. 査読有

種子島
1.  Tanegashima K(7人中1番目), et al. CXCL14 is a natural inhibitor of the CXCL12-CXCR4 signaling axis. FEBS Lett, 587: 1731-1735, 2013. 査読有

北村
1.  Masubuchi Y, Kitamura T(9人中5番目). A novel regulatory function of sweet taste-sensing receptor in adipogenic differentiation of 3T3-L1 cells. PLoS ONE, 8: e54500. 2013. 査読有
2.  Lee Y-S, Kitamura T(18人中18番目). Hypothalamic ATF3 is involved in regulating glucose and energy metabolism in mice. Diabetologia, 56: 1383-1393, 2013. 査読有

野口
1.  Noguchi M(13人中1番目), et al. In vitro characterization and engraftment of adipocytes derived from human induced pluripotent stem cells and embryonic stem cells. Stem Cells Dev, 22: 2895-9605, 2013. 査読有

高柳
1.  Yamashita M, Takayanagi Y (6人中2番目). Involvement of prolactin-releasing peptide in the activation of oxytocin neurones in response to food intake. J Neuroendocrinol, 25: 455-465, 2013. 査読有

船戸
1.  Takase K, Funato H(4人中4番目). Monoaminergic and neuropeptidergic neurons have distinct expression profiles of histone deacetylases. PLoS ONE, 8:e58473, 2013. 査読有

土田
1.  Oishi T, Tsuchida K(7人中7番目). Osteogenic differentiation capacity of human skeletal muscle-derived progenitor cells. PLoS ONE, 8: e56641, 2013. 査読有
2.  Murakami T, Tsuchida K(9人中9番目). Mechanism of cell interactions with water-dispersed carbon nanohorns. Nanosci. Nanotechnol. Lett, 5: 402-407, 2013. 査読有


【受賞】
酒井 真志人/国立国際医療研究センター研究所 糖尿病研究センター 分子代謝制御研究部・室長
日本糖尿病学会・若手研究奨励賞(平成25年5月17日)
「ヒストンアセチル化酵素GCN5による肝臓の糖新生調節機構の解明」

酒井 真志人/国立国際医療研究センター研究所 糖尿病研究センター 分子代謝制御研究部・室長
日本肥満学会・若手研究奨励賞(平成25年10月12日)
「ヒストンアセチル化酵素GCN5による肝臓の糖新生調節機構の解明」

岩倉 浩/京都大学大学院医学研究科 メディカルイノベーションセンター 准教授
第86回日本内分泌学会研究奨励賞(平成25年4月25日)
「グレリン産生細胞株樹立によるグレリン生合成、分泌調節機構の解明」

前嶋 翔、岩越栄子、佐藤慧太、坂本浩隆、坂本竜哉、浮穴和義/広島大学総合研究科
第37回日本比較内分泌学会大会 若手研究者最優秀発表賞(2012年11月30日)
「ラットの視床下部新規神経ペプチドの形態学的解析-既知の生理活性物質との相関と絶食処理に伴う変化-」

秋枝さやか(連携研究者)/宮崎大学フロンティア科学実験総合センター
第155回日本獣医学会 学会長賞(平成25年3月28日)
「マクロファージのグアニリン/GC-Cによる脂肪滴蓄積制御機構」


■2012
【業績論文】
研究代表者が二重下線、研究分担者は一重下線、corresponding authorは左に*印で明示
≪計画研究≫
寒川
1.  Ida T, Miyazato M, Kangawa K(18人中16,17番目). Isolation of the bioactive peptides CCHamide-1 and CCHamide-2 from Drosophila and their putative role in appetite regulation as ligands for G protein-coupled receptors. Front Endocrinol (Lausanne), 3: 177. 2012.
2.  Mori M, Miyazato M, Kangawa K(9人中6,7番目). Different distribution of neuromedin S and its mRNA in the rat brain: NMS peptide is present not only in the hypothalamus as the mRNA, but also in the brainstem. Front Endocrinol (Lausanne), 3: 152, 2012.
3.  Hotta M, Ohwada R, Akamizu T, Shibasaki T, Kangawa K(5人中5番目). Therapeutic potential of ghrelin in restricting-type anorexia nervosa. Methods Enzymol, 514: 381-398, 2012.
4.  Ariyasu H, Kangawa K(6人中5番目). Transgenic mice overexpressing ghrelin or ghrelin analog. Methods Enzymol, 514: 371-377, 2012.
5.  Hosoda H, Kangawa K(2人中2番目). Standard sample collections for blood ghrelin measurements. Methods Enzymol, 514: 113-126, 2012.
6.  Kaiya H, Kangawa K, Miyazato M(4人中3,4番目). Determination of nonmammalian ghrelin. Methods Enzymol, 514: 75-87, 2012.
7.  Kojima M, Kangawa K(3人中3番目). Purification of rat and human ghrelins. Methods Enzymol, 514: 45-61, 2012.
8.  Yoshida M, Miyazato M, Kangawa K(3人中3番目). Orphan GPCRs and methods for identifying their ligands. Methods Enzymol, 514: 33-44, 2012.
9.   Fukumori R, Kangawa K(8人中6番目). Effects of glucose and volatile fatty acids on blood ghrelin concentrations in calves before and after weaning. J Anim Sci, 90: 4839-4845, 2012.
10.  Sugiyama M, Kangawa K(7人中7番目). Ghrelin improves body weight loss and skeletal muscle catabolism associated with angiotensin II-induced cachexia in mice. Regul Pept, 178: 21-28, 2012.
11.  Miki K, Kangawa K(17人中17番目). Ghrelin treatment of cachectic patients with chronic obstructive pulmonary disease: a multicenter, randomized, double-blind, placebo-controlled trial. PLoS One, 7: e35708, 2012.
12.  Hiura Y, Kangawa K(12人中11番目). Effects of ghrelin administration during chemotherapy with advanced esophageal cancer patients: a prospective, randomized, placebo-controlled phase 2 study. Cancer, 118: 4785-4794, 2012.
13.  *Akamizu T, Kangawa K. The physiological significance and potential clinical applications of ghrelin. Eur J Intern Med, 23: 197-202, 2012. 査読有
14.  *Morozumi N, Kangawa K(10人中10番目). A new strategy for metabolic stabilization of motilin using the C-terminal part of ghrelin. Peptides, 33: 279-284, 2012. 査読有
15.  Mogami S, Kangawa K(6人中5番目). Reduced ghrelin production induced anorexia after rat gastric ischemia and reperfusion. Am J Physiol Gastrointest Liver Physiol, 302: G359-364, 2012. 査読有
16.   Iwasaki E, Kangawa K(7人中6番目). Enhanced gastric ghrelin production and secretion in rats with gastric outlet obstruction. Dig Dis Sci, 57: 858-864, 2012. 査読有
17.  *Akamizu T, Kangawa K(9人中9番目). Analysis of plasma ghrelin in patients with medium-chain acyl-CoA dehydrogenase deficiency and glutaric aciduria type II.. Eur J Endocrinol, 166: 235-240, 2012. 査読有
18.   Mifune H, Kangawa K(7人中6番目). Increased production of active ghrelin is relevant to hyperphagia in nonobese spontaneously diabetic Torii rats. Metabolism, 61: 491-495, 2012. 査読有
19.   Hino J, *Miyazato M, Kangawa K(4人中2,3番目). Bone morphogenetic protein-3b (BMP-3b) is expressed in adipocytes and inhibits adipogenesis as a unique complex. Int J Obes (Lond), 36: 725-734, 2012. 査読有

児島
1.   Hamada N, Kojima M(11人中10番目). Disrupted Regulation of Ghrelin Production Under Antihypertensive Treatment in Spontaneously Hypertensive Rats. Circ J, 2012, in press. 査読有
2.   Sato T, *Kojima M(6人中6番目). Structure, regulation and function of ghrelin. J Biochem , 151: 119-128, 2012. 査読有
3.   Mifune H, Kojima M(7人中7番目). Increased production of active ghrelin is relevant to hyperphagia in nonobese spontaneously diabetic Torii rats. Metabolism , 61: 491-195, 2012 査読有
4.   Ida T, Kojima M(12人中12番目). Identification of the endogenous cysteine-rich peptide trissin, a ligand for an orphan G protein-coupled receptor in Drosophila. Biochem Biophys Res Commun , 14;414 : 44-48, 2012 査読有
5.   Ida T, Kojima M(18人中18番目). Identification of the novel bioactive peptides dRYamide-1and dRYamide-2, ligands for a neuropeptide Y-like receptor in Drosophila. Biochem Biophys Res Commun, 15; 410: 872-877, 2012. 査読有
6.   Kojima M(2人中1番目), et al. Methods in Enzymology. Ghrelin. Preface. Methods Enzymol, 514: xxi, 2012. 査読有
7.   Nishi Y, Kojima M(3人中3番目). Ghrelin acylation by ingestion of medium-chain fatty acids. Methods Enzymol, 514: 303-15, 2012. 査読有
8.   Ohgusu H, Kojima M(3人中3番目). Enzymatic characterization of GOAT, ghrelin O-acyltransferase. Methods Enzymol, 514: 147-63, 2012. 査読有
9.   Sato T, Kojima M (2人中2番目). High-performance liquid chromatography analysis of hypothalamic ghrelin. Methods Enzymol, 514: 101-12, 2012. 査読有
10. Kojima M(3人中1番目). Purification of rat and human ghrelins. Methods Enzymol, 514: 45-61, 2012. 査読有
11. Fukumori R, Kojima M(8人中5番目). Effects of glucose and volatile fatty acids on blood ghrelin concentrations in calves before and after weaning. J Anim Sci, 90: 4839-45, 2012. 査読有

塩田
1.  Hori M, Shioda S (10人中10番目). Unraveling the ischemic brain transcriptome in a permanent middle cerebral artery occlusion mouse model by DNA microarray analysis. Dis Model Mech, 5: 270-283, 2012. 査読有
2.  Sato A, Shioda S (9人中9番目). Interleukin-1 participates in the classical and alternative activation of microglia/macrophages after spinal cord injury. J Neuroinflammation, 9: 65, 2012. 査読有
3. *Takenoya F, Kageyama H, Shioda S (7人中7番目). Neuropeptide W. Front Endocrinol (Lausanne), 3: article 1711-1715, 2012.
4. *Kageyama H, Takenoya F, Kintaka Y*, Shioda S (9人中9番目).  Neuronal circuits involving neuropeptide Y in hypothalamic arcuate nucleus-mediated feeding regulation. Neuropeptides, 46: 285-289, 2012.
5. *Kageyama H, Takenoya F, Shioda S (3人中3番目). Morphological analysis of ghrelin neurons in the hypothalamus. Methods Enzymol, 514: 91-99, 2012.

箕越
1.  Ogawa N, Minokoshi Y (8人中7番目). Intestinal fatty acid infusion modulates food preference as well as calorie intake via the vagal nerve and midbrain–hypothalamic neural pathways in rats. Metabolism, 61: 1312-1320, 2012. 
2.  Minokoshi Y (3人中1番目) , et al.  Regulatory role of leptin in glucose and lipid metabolism in skeletal muscle. Indian J Endocrinol Metab, 16: S562-S568, 2012.
3.  Inagaki-Ohara K, Minokoshi Y (9人中4番目). Enhancement of leptin receptor signaling by SOCS3 deficiency induces development of gastric tumors in mice. Oncogene, 2012 Nov 26, doi: 10.1038/onc.2012.540.
4.  Rodriguez-Araujo G, Minokoshi Y (11人中6番目). Alpha-synuclein elicits glucose uptake and utilization in adipocytes through the Gab1/PI3K/Akt transduction pathway. Cell Mol Life Sci, 70: 1123-1133, 2012.

片桐
1.  Hasegawa Y, *Katagiri H(14人中14番目). Blockade of the Nuclear Factor-κB Pathway in the Endothelium Prevents Insulin Resistance and Prolongs Life Spans. Circulation,125: 1122-1133. 2012. 査読有
2.  Uno K, *Katagiri H(11人中11番目). Hepatic peroxisome proliferator-activated receptor-γ-fat-specific protein 27 pathway contributes to obesity-related hypertension via afferent vagal signals. Eur Heart J, 2012, in press. 査読有
3.  Gao J, *Katagiri H(14人中14番目). Involvement of Endoplasmic Stress Protein C/EBP Homologous Protein in Arteriosclerosis Acceleration With Augmented Biological Stress Responses. Circulation,124: 830-839. 2012. 査読有
4.  Nakatsu Y, Katagiri H(23人中18番目). Peptidyl-prolyl cis/trans isomerase NIMA-interacting 1 associates with insulin receptor substrate-1 and enhances insulin actions and adipogenesis. J Biol Chem, 286:  20812-20822, 2012. 査読有
5.  Usui M, Katagiri H(10人中7番目). Atf6α-null mice are glucose intolerant due to pancreatic β-cell failure on a high-fat diet but partially resistant to diet-induced insulin resistance. Metabolism, 61: 1118-1128, 2012.
6.  Okada S, Katagiri H(13人中11番目). Brain-derived neurotrophic factor protects against cardiac dysfunction after myocardial infarction via a central nervous system-medeiated pathway. Arterioscler Thromb Vasc Biol, 32: 1902-1909, 2012.
7.  Munakata Y, Katagiri H (10人中10番目). A case of slowly progressive type 1 diabetes maintaining insulin independence for 10 years with α-glucosidase inhibitor monotherapy. Internal Medicine, 51: 3391-3394, 2012.
8.  Miyazaki T, Katagiri H(9人中7番目). Intracellular and extracellular ATP coordinately regulate the inverse correlation between osteoclast survival and bone resorption. J Biol Chem, 287: 37808-37823, 2012.
9.  Tsukita S, Katagiri H(12人中12番目). Hepatic glucokinase modulates obesity predisposition by regulating BAT thermogenesis via neural signals. Cell Metab, 16: 825-832, 2012.

中里
1.  Moin AS, Yamaguchi H, Toshinai K, Nakazato M (12人中12番目). Neuroendocrine regulatory peptide-2 stimulates glucose-induced insulin secretion in vivo and in vitro. Biochem Biophys Res Commun, 428: 512-517, 2012.
2.  Miki K, Nakazato M(17人中3番目). Ghrelin treatment of cachectic patients with chronic obstructive pulmonary disease: a multicenter, randomized, double-blind, placebo-controlled trial. PLoS ONE, 2012, in press. 査読有
3.  Ogawa N, Yamaguchi H, *Nakazato M(8人中8番目).Intestinal fatty acid infusion modulates food preference as well as calorie intake via the vagal nerve and midbrain-hypothalamic neural pathways in rats. Metabolism, 2012, in press. 査読有
4.  Tamaki N, Ueno H, *Nakazato M(5人中5番目). Ezetimibe ameliorates atherosclerotic and inflammatory markers, atherogenic lipid profiles, insulin sensitivity, and liver dysfunction in Japanese patients with hypercholesterolemia. J Atheroscler Thromb, 2012, in press. 査読有
5.  *Ueno H, NNakazato M(8人中8番目). Fenofibrate ameliorates insulin resistance, hypertension and novel oxidative stress markers in patients with metabolic syndrome. Obes Res Clin Pract, 2012, in press. 査読有

清水
1.  Tagaya Y, Shimizu H (10人中9番目).  Secreted nucleobindin-2 inhibits 3T3-L1 adipocyte differentiation.  Protein & Peptide Lett, 2012 [Epub ahead of print]. 査読有
2.  Osaki A, *Shimizu H (6人中2番目). Enhanced expression of nesfatin/nucleobindin-2 (NUCB2) in white adipose tissue of ventromedial hypothalamus (VMH)-lesioned rats.  Neurosci Lett, 2012. [Epub ahead of print]. 査読有

船橋
1.  Nakanishi-Minami T, Kishida K, Funahashi T(10人中9番目). Metabolic syndrome correlates intracoronary stenosis detected by multislice computed tomography in male subjects with sleep-disordered breathing. Diabetol Metab Syndr, 1; 4-6, 2012.
2.  Nakanishi-Minami T, Kishida K, Funahashi T(4人中3番目). Sleep-wake cycle irregularities in type 2 diabetics. Diabetol Metab Syndr, 4: 18, 2012.
3.  Nakagawa Y, Kishida K, Funahashi T(5人中3番目). Coexistence of visceral fat accumulation and sleep-disordered breathing correlates with coronary artery disease. J Atheroscler Thromb, 19: 728-735, 2012.
4.  Hirata A, Kishida K, Funahashi T(6人中2,5番目). Metabolic syndrome correlates with polyvascular lesions detected by systemic vascular ultrasonography in Japanese people with type 2 diabetes. Diabetes Res Clin Pract, 96: e26-29, 2012. 査読有
5.  Sekimoto R, Kishida K, Funahashi T(6人中2,5番目). High circulating levels of S100A8/A9 complex (calprotectin) in male Japanese with abdominal adiposity and dysregulated expression of S100A8 and S100A9 in adipose tissues of obese mice. Biochem Biophys Res Commun, 419: 782-789, 2012. 査読有
6.  Nakatsuji H, Kishida K, Funahashi T(5人中2,3番目). Hyperinsulinemia correlates with low levels of plasma B-type natriuretic peptide in Japanese men irrespective of fat distribution. Cardiovasc Diabetol, 11: 22, 2012. 査読有
7.  Kishida K, Funahashi T(3人中1,2番目). Clinical importance of assessment of type 2 diabetes mellitus with visceral obesity. A Japanese perspective. Curr Diabetes Rev, 2012. 査読有
8.  Hirata A, Kishida K, Funahashi T(7人中2,6番目). High prevalence of gastroesophageal reflux symptoms in type 2 diabetics with hypoadiponectinemia and metabolic syndrome. Nutr Metab (Lond),9:4, 2012. 査読有
9.  Kishida K, Funahashi T(3人中1,2番目). Molecular mechanisms of diabetes and atherosclerosis: Role of adiponectin. Endocr Metab Immune Disord Drug Targets, 2012. 査読有
10. Hirata A, Kishida K, Funahashi T(6人中2,5番目). High serum S100A8/A9 levels and high cardiovascular complication rate in type 2 diabetics with ultrasonographic low carotid plaque density.Diabetes Res Clin Pract, 2012, in press. 査読有

小川
1.  Kubota H, Ogawa W (8人中7番目). Temporal Coding of Insulin Action through Multiplexing of the AKT Pathway. Mol. Cell46: 820-832, 2012. 査読有
2.  Sakaguchi K, Ogawa W (12人中4番目). Minimally Invasive System for Glucose Area Under the Curve Measurement Using Interstitial Fluid Extraction Technology: Evaluation of the Accuracy and Usefulness with Oral Glucose Tolerance Tests in Subjects With and Without Diabetes. Diabetes Technol Ther, 14: 485-491, 2012. 査読有
3.  Tawaramoto K, Ogawa W (12人中7番目). Ablation of 3-phosphoinositide-dependent protein kinase 1 (PDK1) in vascular endothelial cells enhances insulin sensitivity by reducing visceral fat and suppressing angiogenesis. Mol Endocrinol, 26: 95-109, 2012. 査読有
4.  Shim JH, Ogawa W (13人中7番目). Administration of BMP2/7 in utero partially reverses Rubinstein-Taybi syndrome-like skeletal defects induced by Pdk1 or Cbp mutations in mice. J Clin Invest, 122: 91-106, 2012. 査読有
5.  Takabe M, Ogawa W (8人中7番目). C-peptide response to glucagon challenge is correlated with the improvement of early insulin secretion by liraglutide treatment. Diabetes Res Clin Pract. 98: e32-35, 2012. 査読有
6.  Kikani CK, Ogawa W (15人中12番目). Proliferative and Antiapoptotic Signaling Stimulated by Nuclear-Localized PDK1 Results in Oncogenesis. Sci Signal. 5: ra80. doi: 10.1126/ scisignal. 2003065, 2012.

細田
1.  Odori S, Hosoda K(12人中2番目). GPR119 expression in normal human tissues and islet cell tumors : evidence for its islet-gastrointestinal distribution, expression in pancreatic beta and alpha cells, and involvement in islet function. Metabolism, 2012, in press.
2.  Fujikura J, Hosoda K(13人中12番目). Induced pluripotent stem cells generated from diabetic patients with mitochondrial DNA A3243G mutation. Diabetologia, 55: 1689-1698, 2012. 査読有
3.  Kusakabe T, Hosoda K(11人中10番目). Amylin improves the effect of leptin on insulin sensitivity in leptin-resistant diet-induced obese mice. Am J Physiol Endocrinol Metab, 2012 , in press. 査読有
4.  Bando M, Hosoda K(10人中6番目). Transgenic overexpression of intraislet ghrelin does not affect insulin secretion or glucose metabolism in vivo. Am J Physiol Endocrinol Metab ,302(4): E403-408, 2012. 査読有
5.  Miyamoto L, Hosoda K(12人中11番目). Leptin activates hepatic 5' AMP-Activated Protein Kinase through sympathetic nervous system and α1 adrenergic receptor: A potential mechanism for improvement of fatty liver in lipodystrophy by leptin. J Biol Chem, 287: 40441-40447, 2012.
6.  Aotani D, Hosoda K(13人中11番目). Functional magnetic resonance imaging analysis of food-related brain activity in patients with lipodystrophy undergoing leptin-replacement therapy. J Clin Endocrinol Metab, 97: 3663-3671, 2012.
7.  Yamada-Goto N, Hosoda K(7人中6番目). Impairment of fear-conditioning responses and changes of brain neurotrophic factors in diet-induced obese mice. Journal of Neuroendocrinology, 24: 1120-1125, 2012.
8.  Nakao YM, Hosoda K(11人中9番目). Intra-abdominal fat area is a predictor for new onset of individual components of metabolic syndrome: MEtabolic syndRome and abdominaL ObesiTy (MERLOT study). Proc Jpn Acad Ser B Phys Biol Sci, 88: 454-461, 2012.
9.  Iwanishi M, Hosoda K(8人中7番目). Premature atherosclerosis in a Japanese diabetic patient with atypical familial partial lipodystrophy and hypertriglyceridemia. Intern Med, 51: 2573-2579, 2012.
10. Kawabata H, Hosoda K(14人中7番目). A case of congenital dyserythropoietic anemia type 1 in a Japanese adult with a CDAN1 gene mutation and an inappropriately low serum hepcidin-25 level. Intern Med, 51:917-920, 2012.

≪公募研究≫
[平成23年度~平成24年度]
浮穴
1.  Ubuka T, Ukena K(7人中5番目). Identification, expression, and physiological functions of siberian hamster gonadotropin-inhibitory hormone. Endocrinology, 153: 373-385, 2012. 査読有

斎藤
1.  Kobayashi Y, Saito Y(4人中3番目). *Takahashi A. Melanocortin systems on pigment dispersion in fish chromatophores. Frontiers in Experimental Endocrinology, 3: 9, 2012. 査読有
2.  Hamamoto A, Saito Y(4人中4番目). Mutation of Phe318 within the NPxxY(x)5,6F motif in melanin-concentrating hormone receptor 1 results in an efficient signaling activity. Front. Endocrinology, 3: 147, 2012. 査読有

和田
1.  Nakatsuka A, *Wada J(14人中2番目). RXR antagonism induces G0/G1 cell cycle arrest and ameliorates obesity by up-regulating the p53-p21Cip1 pathway in adipocytes. J Pathol , 26: 784-795, 2012
2.  Hida K, *Wada J (10人中9番目). Impact of circulating vaspin levels on metabolic variables in elderly twins. Diabetologia, 55: 530-532, 2012
3.  Kanzaki M, *Wada J (13人中2番目). Galectin-9 and T cell immunoglobulin mucin-3 pathway is a therapeutic target for type 1 diabetes. Endocrinology, 153: 612-620, 2012
4.  Kawai D, Wada J(14人中4番目). Hydrogen-rich water prevents progression of non-alcoholic steatohepatitis and accompanying hepatocarcinogenesis in mice. Hepatology, doi: 10.1002/hep.25782. [Epub ahead of print]2012
5.  Teshigawara S, *Wada J (16人中2番目). Serum vaspin concentrations are closely related to insulin resistance and rs77060950 at SERPINA12 genetically defines distinct group with higher serum levels in Japanese population. J Clin Endocrinol Metab, [Epub ahead of print]2012
6.  Kanzaki M, Wada J(7人中2番目). The therapeutic potential of synthetic human atrial natriuretic peptide in nephrotic syndrome: a randomized controlled trial. Int J Nephrol Renovasc Dis, 5: 91-96, 2012. 査読有
7.  Nakatsuka A, Wada J (20人中2番目). Vaspin is an adipokine ameliorating ER stress in obesity as a ligand for cell-surface GRP78/MTJ-1 complex. Diabetes, 61: 2823-2832, 2012. 査読有
8.  Tachibana H, Wada J (11人中5番目). Activation of liver x receptor inhibits osteopontin and ameliorates diabetic nephropathy. J Am Soc Nephrol, 23: 1835-1846, 2012. 査読有
9.  Inoue J, Wada J (12人中2番目). The serum vaspin levels are reduced in Japanese chronic hemodialysis patients. BMC Nephrol, 13: 163, 2012. 査読有

伊達
1.   Poleni PE, *Date Y (9人中9番目). Possible involvement of melanocortin-4-receptor and AMP-activated protein kinase in the interaction of glucagon-like peptide-1 and leptin on feeding in rats. Biochem Biophys Res Commun, 420: 36-41, 2012. 査読有
2.   Date Y. Ghrelin and the Vagus Nerve. Methods in Enzymology, 514: 261-269, 2012. 査読中
3.   Date Y(2人中1番目). Ghrelin as a starvation signal. Obesity Research & Clinical Practice 6: e263-269, 2012. 査読中

長南
1.  Chohnan S(6人中5番目). Anorexic behavior and elevation of hypothalamic malonyl-CoA in socially defeated rats. Biochem Biophys Res Commun, 421: 301-304, 2012. 査読中
2.  Tokutake Y, Chohnan S(7人中7番目). Effect of diet composition on coenzyme A and its thioester pools in various rat tissues, Biochem. Biophys. Res. Commun., 423(4), 781-784, 2012. 査読有

中川
1.  Naka A, Nakagawa Y(16人中3番目). TFE3 inhibits myoblast differentiation in C2C12 cells via down-regulating gene expression of myogenin. Biochem Biophys Res Commun, 2012 in press. 査読有
2.  Lerner AG, Nakagawa Y(17人中5番目). IRE1α Induces Thioredoxin-Interacting Protein to Activate the NLRP3 Inflammasome and Promote Programmed Cell Death under Irremediable ER Stress. Cell Metabolism, 16:250-64,2012. 査読有
3.  Matsuzaka T, Nakagawa Y(21人中8番目). Elovl6 promotes nonalcoholic steatohepatitis in mice and humans. Hepatology, 2012 in press. 査読有
4.  Fujimoto Y, *Nakagawa Y(他14人2番目). Dicer has a crucial role in the early stage of adipocyte differentiation, but not in lipid synthesis, in 3T3-L1 cells. Biochem Biophys Res Commun, 420: 931-936, 2012.査読有
5.  Iwasaki H, Nakagawa Y(他12人4番目). TFE3 regulates muscle metabolic gene expression, increases glycogen stores, and enhances insulin sensitivity in mice. Am J Physiol Endocrinol Metab, 302: E896-902, 2012. 査読有

南野
1.  Naito AT, Minamino T (25人中18番目). Complement C1q activates canonical wnt signaling and promotes age-related phenotypes. Cell, 149: 1298-1313, 2012. 査読有
2.  Okada S, *Minamino T (13人中12番目). Brain-derived neurotrophic factor protects against cardiac dysfunction after myocardial infarction via a central nervous system-mediated pathway. Arterioscler Thromb Vasc Biol, 2012, 32: 1902-1909, 2012. 査読有
3.  Yasuda N, Minamino T (17人中10番目). Agonist-independent constitutive activity of angiotensin II receptor promotes cardiac remodeling in mice. Hypertension, 59: 627-633, 2012. 査読有
4.  Shimizu I, *Minamino T (13人中13番目). p53-induced adipose tissue inflammation is critically involved in the development of insulin resistance in heart failure. Cell Metab, 15: 51-64, 2012. 査読有
5.  Nakano D, Minamino T (10人中9番目). Aldosterone does not contribute to renal p21 expression during the development of angiotensin II-induced hypertension in mice. Am J Hypertens, 25: 354-358, 2012. 査読有

井上順
1.  Miyata S, Inoue J(4人中2番目). 4′-Hydroxyflavanone suppresses activation of sterol regulatory element-binding proteins and de novo lipid synthesis. FEBS Lett, 2012, in press. 査読有
2.   Yashiro T, Inoue J(5人中4番目). Resveratrol increases the expression and activity of the low density lipoprotein receptor in hepatocytes by the proteolytic activation of the sterol regulatory element-binding proteins. Atherosclerosis, 220: 369-374, 2012. 査読有

亀井
1.  Ehara T, Kamei Y(13人中2番目、*Equal contribution). Role of DNA methylation in the regulation of lipogenic gene expression in the mouse neonatal liver. Diabetes, 61: 2442-2450, 2012. 査読有

井上啓
1.  Kitade H, Inoue H(13人中4番目). CCR5 Plays a Critical Role in Obesity-Induced Adipose Tissue Inflammation and Insulin Resistance by Regulating Both Macrophage Recruitment and M1/M2 Status. Diabetes, 2012, in press.
2.  Sakai M, Inoue H(14人中7番目). CITED2 links hormonal signaling to PGC-1α acetylation in the regulation of gluconeogenesis. Nat Med, 18: 612-617, 2012.
3.  Kimura K, *Inoue H(14人中14番目). Endoplasmic Reticulum Stress Inhibits STAT3-dependent Suppression of Hepatic Gluconeogenesis via Dephosphorylation and Deacetylation. Diabetes, 61: 61-73, 2012.

岩倉
1.  Kawano K, Iwakura H(5人中3番目). Adrenal tumor volume in a genetically engineered mouse model of neuroblastoma determined by magnetic resonance imaging. Exp Ther Med, 4: 61-64, 2012. 査読有
2.  Bando M, *Iwakura H(10人中2番目). Transgenic overexpression of intra-islet ghrelin does not affect insulin secretion or glucose metabolism in vivo. Am J Physiol Endocrinol Metab, 302: E403-408,2012. 査読有
3.  *Akamizu T, Iwakura H(9人中7番目). Analysis of plasma ghrelin in patients with medium-chain acyl-CoA dehydrogenase deficiency and glutaric aciduria type II.. Eur J Endocrinol, 166: 235-240,2012. 査読有

錦見
1.  Minami T, Nishikimi T(22人中13番目). Reciprocal expression of MRTF-A and myocardin is crucial for pathological vascular remodelling in mice. EMBO J, 31: 4428-4440, 2012. 査読有
2.  Kuwahara K, Nishikimi T(3人中2番目). Transcriptional regulation of the fetal cardiac gene program. J Pharmacol Sci, 119: 198-203, 2012. 査読有
3.  *Nishikimi T(9人中1番目), et al. The effect of glycosylation on plasma N-terminal proBNP-76 levels in patients with heart or renal failure. Heart, 98: 152-461, 2012. 査読有
4.  Nishikimi T(3人中1番目), et al. Adrenomedullin in heart failure: molecular mechanism and therapeutic implication. Current Hypertension Reviews, 7: 273-283, 2012. 査読有

志内
1.  Ogawa N, Shiuchi T(8人中4番目). Intestinal fatty acid infusion modulates food preference as well as calorie intake via the vagal nerve and midbrain-hypothalamic neural pathways in rats. Metabolism, 2012. [Epub ahead of print]査読有

山縣
1.  Sato Y, Yamagata K(12人中12番目). Anks4b, a novel target of HNF4α protein, interacts with GRP78 protein and regulates endoplasmic reticulum stress-induced apoptosis in pancreatic β-cells. J Biol. Chem, 287: 23236-23245, 2012. 査読有
2.  Ohki T, Yamagata K(6人中6番目). Identification of hepatocyte growth factor activator (Hgfac) gene as a target of HNF1α in mouse β-cells. Biochem Biophys Res Commun, 425: 619-624, 2012. 査読有

前島
1.  Gantulga D, Maejima Y(4人中2番目). Glucose and insulin signaling in  nesfatin-1 neurons in the hypothalamic paraventricular nucleus. Biochem Biophys Res Commun, 420: 811-815, 2012.
2.  Yada T, Maejima Y(10人中3番目). Neurohormones, rikkunshito and hypothalamic neurons interactively control appetite and anorexia. Curr Pharm Des, 18: 4854-4864, 2012.

豊島
1.   Asano T, Toyoshima H (8人中5番目). Central diabetes insipidus and hypothalamic type of hypopituitarism associated with atypical location of Rathke's cleft cyst. Intern Med, 51:189-194, 2012. 査読有
2.   Sone H, Tanaka S, Tanaka S, Iimuro S, Ishibashi S, Oikawa S, Shimano H, Katayama S, Ohashi Y, Akanuma Y, Yamada N; Japan Diabetes Complications Study Group. Comparison of various lipid variables as predictors of coronary heart disease in Japanese men and women with type 2 diabetes: subanalysis of the Japan Diabetes Complications Study., Diabetes Care, 35: 1150-1157, 2012. doi: 10.2337/dc11-1412.

種子島
1.  *Hara T, Tanegashima K. Pleiotropic functions of the CXC-type chemokine CXCL14 in mammals. J Biochem, 151: 469-476, 2012. 査読有

北村
1.  Kitamura YI, *Kitamura T(10人中10番目). Hepatic FoxO1 Integrates Glucose Utilization and Lipid Synthesis Through Regulation of Chrebp O-glycosylation. PLoS ONE, 7: e47231, 2012. 査読有
2.  Nakakura T, Kitamura T(13人中11番目). Deficiency of Proton-Sensing Ovarian Cancer G Protein-Coupled Receptor 1 Attenuates Glucose-Stimulated Insulin Secretion. Endocrinology, 153: 4171-4180, 2012. 査読有
3.  Hasegawa K, Kitamura T(7人中6番目). Necdin controls Foxo1 acetylation in hypothalamic arcuate nucleus to modulate the thyroid axis. J Neuroscience, 32: 5562-5572, 2012. 査読有
4.  Talchai C, Kitamura T(5人中3番目). Generation of functional insulin-producing cells in the gut by Foxo1 ablation. Nat Genet, 44: 406-412, 2012. 査読有
5.  Kikuchi O, Kitamura T(10人中10番目). FoxO1 Gain of Function in the Pancreas Causes Glucose Intolerance, Polycystic Pancreas, and Islet Hypervascularization. PLoS ONE, 7: e32249, 2012. 査読有
6.  Kobayashi M, Kitamura T(11人中11番目). FoxO1 as a Double-edged Sword in the Pancreas: Analysis of Pancreas and β Cell-specific FoxO1 Knockout Mice. Am J Physiol Endocrinol Metab, 302: E603-613, 2012. 査読有
7.  Kim H-J, Kitamura T(12人中12番目). Over-expression of FoxO1 in the Hypothalamus and Pancreas Causes Obesity and Glucose Intolerance. Endocrinology, 153: 659-671, 2012. 査読有

高柳
1.  *Onaka T, Takayanagi Y(3人中2番目). Roles of oxytocin neurones in the control of stress, energy metabolism, and social behaviour. Journal of Neuroendocrinology, 24: 587-598, 2012. 査読有
2.   高柳友紀、尾仲達史.プロラクチン放出ペプチド(PrRP).Clinical Neuroscience ニューロペプチド-update, 30: 176-177, 2012.査読無
3.   尾仲達史、高柳友紀、吉田匡秀.オキシトシンとストレス緩和作用.Clinical Neuroscience ニューロペプチド-update, 30: 212-215, 2012.査読無

千田
1.  Sato T, Chida D(11人中9番目). Proteomic analysis of a masticatory muscle tendon-aponeurosis hyperplasia: a preliminary study using 2D-DIGE system. JOral Maxillofacial Surg, Medicine,and Pathology, 2012, in press. 査読有

菅波
1.  Ehara T, Suganami T(13人中11番目). Role of DNA methylation in the regulation of lipogenic glycerol-3-phosphate acyltransferase 1 gene expression in the mouse neonatal liver. Diabetes, 61: 2442-2450, 2012.査読有
2.  Satoh-Asahara N, Suganami T(13人中11番目). Highly purified eicosapentaenoic acid increases interleukin-10 levels of peripheral blood monocytes in obese patients with dyslipidemia. Diabetes Care, 35: 2631-2639, 2012.査読有

増谷
1.  Masaki S, Masutani H (4人中2番目). Deficiency of Thioredoxin binding protein-2 (TBP-2) enhances TGF-β signaling and promotes Epithelial to Mesenchymal Transition.  PLoS ONE, 7: e39900, 2012 査読有
2.  *Masutani H (5人中1番目). Thioredoxin binding protein (TBP)-2/Txnip and α-arrestin proteins in cancer and diabetes mellitus. J Clin Biochem Nutr, 50: 23-34, 2012. 査読有

野口
1.  Fujikura J, Noguchi M(13人中4番目). Induced pluripotent stem cells generated from diabetic patients with mitochondrial DNA A3243G mutation. Diabetologia, 55: 1689-1698, 2012. 査読有

海老原
1.  Miyamoto L, Ebihara K(12人中2番目). Leptin activates hepatic 5' AMP-Activated Protein Kinase through sympathetic nervous system and α1 adrenergic receptor: A potential mechanism for improvement of fatty liver in lipodystrophy by leptin. J Biol Chem, 287: 40441-40447, 2012.
2.  Iwanishi M, Ebihara K(8人中番目). Premature atherosclerosis in a Japanese diabetic patient with atypical familial partial lipodystrophy and hypertriglyceridemia. Intern Med, 51: 2573-2579, 2012.
3.  Aotani D, Ebihara K(13人中2番目). Functional magnetic resonance imaging analysis of food-related brain activity in patients with lipodystrophy undergoing leptin-replacement therapy. J Clin Endocrinol Metab, 97: 3663-3671, 2012.
4.  Yamada-Goto N, Ebihara K(7人中4番目). Impairment of fear-conditioning responses and changes of brain neurotrophic factors in diet-induced obese mice. Journal of Neuroendocrinology, 2012, in publication.  査読有
5.  Kusakabe T, Ebihara K(11人中2番目). Amylin improves the effect of leptin on insulin sensitivity in leptin-resistant diet-induced obese mice. Am J Physiol Endocrinol Metab, 302: E924-931, 2012. 査読有

阪上
1.  Kikani CK, Sakaue H (15人中8番目). Proliferative and antiapoptotic signaling stimulated by nuclear-localized PDK1 results in oncogenesis. Sci Signal, 5: ra80, 2012
2.  Shiota A, Sakaue H(12人中9番目). Activation of AMPK-Sirt1 pathway by telmisartan in white adipose tissue: A possible link to anti-metabolic effects. Eur J Pharmacol, 692: 84-90, 2012.
3.  Harada N, Sakaue H (4人中5番目). Identification and functional characterization of human glycerol-3-phosphate acyltransferase 1 gene promoters. Biochem Biophys Res Commun, 2012. [Epub ahead of print] 査読有
4.  Nakagawa T, Sakaue H (10人中9番目). Membrane topology of murine glycerol-3-phosphate acyltransferase 2. Biochem Biophys Res Commun, 418: 506-511, 2012. 査読有
5.  Tawaramoto K, Sakaue H (6人中12番目). Ablation of 3-phosphoinositide-dependent protein kinase 1 (PDK1) in vascular endothelial cells enhances insulin sensitivity by reducing visceral fat and suppressing angiogenesis. Mol Endocrinol, 26: 95-109, 2012. 査読有

土田
1. Ohsawa Y, Tsuchida K (14人中9番目). An inhibitor of transforming growth factor beta type I receptor ameliorates muscle atrophy in a mouse model of caveolin 3-deficient muscular dystrophy. Lab. Invest, 92: 1100-1114, 2012. 査読有


【受賞】
菅波孝祥/東京医科歯科大学難治疾患研究所代謝医学分野 准教授
東京医科歯科大学・優秀研究賞(平成24年10月14日)
「メタボリックシンドロームの病態整理の解明と新しい治療戦略の開発に関する分子医学的研究

菅波孝祥/東京医科歯科大学難治疾患研究所代謝医学分野 准教授
日本内分泌学会・研究奨励賞(平成24年4月19日)
「脂肪組織炎症による新しいアディポサイトカイン産生調節の分子機構の解明」

亀井安富/京都府立大学・生命環境科学研究科 教授
第33回日本肥満学会 2012年度日本肥満学会学術奨励賞(平成24年10月13日)
「肥満・生活習慣病における核内受容体・転写共役因子の病態生理的意義の解明」

岸田 堅(分担研究者)/大阪大学・大学院医学系研究科 内分泌・代謝内科学 特任講師
第9回井村臨床研究奨励賞(平成24年12月8日)
「内臓脂肪蓄積学を基盤とした血管疾患予防・治療対策の構築」

野村和弘(連携研究者)/神戸大学・大学院医学研究科 糖尿病・内分泌内科
第85回日本内分泌学会 若手研究奨励賞(平成24年4月1日)
「PGC1α新規スプライスングバリアントのエネルギー代謝制御における機能の検討」

野村和弘(連携研究者)/神戸大学・大学院医学研究科 糖尿病・内分泌内科
第24回分子糖尿病学研究奨励賞(平成24年12月8日)
「PGC1α新規アイソトープの肥満病態形成における関与の検討」

野村和弘(連携研究者)/神戸大学・大学院医学研究科 糖尿病・内分泌内科
日本糖尿病・肥満動物学会若手研究奨励賞(平成24年2月17日)
「PGC1αスプライスングバリアントのエネルギー代謝制御における機能の検討」

中畑泰和/奈良先端科学技術大学院大学・バイオサイエンス研究科・助教
第9回 (2011年度) 日本時間生物学会学術奨励賞(平成24年1月26日)
「エネルギー代謝による概日時計制御の研究」


■2011
【業績論文】
研究代表者が二重下線、研究分担者は一重下線、corresponding authorは左に*印で明示
≪計画研究≫
寒川
1.  *Ida T, Miyazato M, Kangawa K(12人中10, 11番目). Identification of the endogenous cysteine-rich peptide trissin, a ligand for an orphan G protein-coupled receptor in Drosophila. Biochem Biophys Res Commun, 414: 44-48, 2011. 査読有
2.  *Ida T, Miyazato M, Kangawa K (18人中14, 17番目). Identification of the novel bioactive peptides dRYamide-1 and dRYamide-2, ligands for a neuropeptide Y-like receptor in Drosophila. Biochem Biophys Res Commun, 410: 872-877, 2011. 査読有
3.  *Akamizu T, Kangawa K. Therapeutic applications of ghrelin to cachexia utilizing its appetite-stimulating effect. Peptides, 32: 2295-2300, 2011. 査読有
4.  *Kaiya H, Miyazato M, Kangawa K. Recent advances in the phylogenetic study of ghrelin. Peptides, 32: 2155-2174, 2011. 査読有
5.  *Kishimoto I, Kangawa K(4人中1, 4番目). Natriuretic peptide system: an overview of studies using genetically engineered animal models. FEBS J, 278: 1830-1841, 2011. 査読有
6.  *Koizumi M, Kangawa K(10人中6番目). Postoperative weight loss does not resolve after esophagectomy despite normal serum ghrelin levels. Ann Thorac Surg, 91: 1032-1037, 2011. 査読有
7.  *Okano I, Miyazato M, Kangawa K. A guanosine 3',5'-cyclic monophosphate (cGMP) reporter system based on the G-kinase/CREB/CRE signal transduction pathway. Biochem Biophys Res Commun, 407: 236-241, 2011. 査読有
8.  Sakamoto T, Miyazato M, Kangawa K(8人中6, 7番目). Neuromedin S regulates cardiovascular function through the sympathetic nervous system in mice. Peptides, 32: 1020-1026, 2011. 査読有
9.  Morozumi N, Kangawa K(10人中10番目). The role of C-terminal part of ghrelin in pharmacokinetic profile and biological activity in rats. Peptides, 32: 1001-1007, 2011. 査読有

児島
1.  Nanjo Y, Kojima M(15人中14番目). Factors associated with plasma ghrelin level in Japanese general population. Clin Endocrinol (Oxf) , 74: 453-458, 2011. 査読有
2.  Yoh J, Kojima M(12人中10番目). Plasma levels of n-decanoyl ghrelin, another acyl- and active-form of ghrelin, in human subjects and the effect of glucose- or meal-ingestion on its dynamics. Regul Pept , 25; 167: 140-148, 2011. 査読有
3.  Sato T, Kojima M(5人中5番目). Continuous antagonism of the ghrelin receptor results in early induction of salt-sensitive hypertension. J Mol Neurosci, 43: 193-199, 2011. 査読有

塩田
1.  Kamijo M, Shioda S(10人中8番目). Neuropeptide Y in tiger puffer (Takifugu rubripes): distribution, cloning, characterization, and mRNA expression responses to prandial condition. Zoolog Sci, 28: 882-890, 2011. 査読有
2.  Kang KS, Shioda S(6人中5番目). Effect of intraperitoneal injection of curcumin on food intake in a goldfish model. J Mol Neurosci, 45: 172-176, 2011. 査読有
3.  Maruyama K, Shioda S(9人中7番目). Isolation and characterisation of two cDNAs encoding the neuromedin U receptor from goldfish brain. J Neuroendocrinol, 23: 282-291, 2011. 査読有
4.  Matsuo E, Shioda S(11人中6番目). Decreased intake of sucrose solutions in orexin knockout mice. J Mol Neurosci, 43: 217-224, 2011. 査読有
5.  Mihara Y, Shioda S(6人中7番目). Expression and localization of the orexin-1 receptor (OX1R) after traumatic brain injury in mice. J Mol Neurosci, 43: 162-168, 2011. 査読有
6.  Namba T, Shioda S(8人中7番目). Time-lapse imaging reveals symmetric neurogenic cell division of GFAP-expressing progenitors for expansion of postnatal dentate granule neurons. PLoS One, 6: e25303, 2011. 査読有
7.  Ogawa T, Shioda S(10人中1,10番目). Distribution of the longevity gene product, SIRT1, in developing mouse organs. Congenit Anom (Kyoto), 51: 70-79, 2011. 査読有
8. Shioda S, Kageyama H, Takenoya F, Shiba K. Galanin-like peptide: a key player in the homeostatic regulation of feeding and energy metabolism? Int J Obes (Lond), 35: 619-628, 2011. 査読有(総説)
9.  Yamazaki S, Shioda S(10人中6番目). Nonmyelinating Schwann cells maintain hematopoietic stem cell hibernation in the bone marrow niche. Cell, 147: 1146-1158, 2011. 査読有

箕越
1.  Saito K, *Minokoshi Y(8人中8番目). An enzymatic photometric assay for 2-deoxyglucose uptake in insulin-responsive tissues and 3T3-L1 adipocytes. Analytical Biochem, 412: 9-17, 2011. 査読有
2.  Matsuo E, Minokoshi Y(11人中10番目). Decreased intake of sucrose solutions in orexin knockout mice. J Mol Neurosci, 43: 217-224, 2011. 査読有
3.  Hoivik EA, Minokoshi Y(9人中6番目). DNA methylation of intronic enhancers directs tissue-specific expression of steroidogenic factor 1/adrenal 4 binding protein (SF-1/Ad4BP). Endocrinology, 152: 2100-2112, 2011. 査読有
4.  Cao Y, Minokoshi Y(18人中6番目). PDK1-Foxo1 in Agouti-related peptide neurons regulates energy homeostasis by modulating food intake and energy expenditure. PLoS ONE, 6: e18324, 2011. 査読有
5.  Tanaka M, Minokoshi Y(9人中8番目). Role of central leptin signaling in the starvation-induced alteration of B cell development. J Neurosci, 31: 8373-8380, 2011. 査読有
6.  Uchida K, Minokoshi Y(9人中8番目). Metabolic adaptation of mice in a cool environment. Lack of TRPM2 impaired insulin secretion and glucose metabolisms in mice. Diabetes, 60: 119-126, 2011. 査読有
7.  Uchida K, Minokoshi Y(9人中8番目). Metabolic adaptation of mice in a cool environment. Lack of TRPM2 impaired insulin secretion and glucose metabolisms in mice. Diabetes, 60: 119-126, 2011. 査読有

片桐
1.  Toshihiro M, Katagiri H(9人中2番目).Recurrent hypoglycemia during pregnancies in a woman with multiple autoantibodies including anti-insulin receptor antibody and anti-platelet antibody, whose serum lowered murine blood glucose levels and phosphorylated insulin receptor of CHO-IR cells. Endocr J, 58: 1037-43 2011. 査読有
2.  Sugita S, Katagiri H (21人中14番目). Increased systemic glucose tolerance with increased muscle glucose uptake in transgenic mice overexpressing RXRγ in skeletal muscle. PLoS One, 6: e20467, Epub, 2011. 査読有
3.  Kudo H, *Katagiri H(10人中9番目). Frequent loss of genome gap region in 4p16.3 subtelomere in early-onset type 2 diabetes mellitus. Exp Diabetes Res, 498460, 2011. 査読有
4.  Ohno H, Katagiri H (16人中14番目). 4F2hc stabilizes GLUT1 protein and increases glucose transport activity. Am J Physiol Cell Physiol, 300: C1047- C1054, 2011. 査読有
5.  Suzuki T, *Katagiri H(10人中10番目). Interleukin-6 Enhances Glucose-Stimulated Insulin Secretion From Pancreatic β-Cells: Potential Involvement of the PLC-IP3-Dependent Pathway. Diabetes, 60: 537-547, 2011. 査読有
6.  Onoyama I, Katagiri H(8人中5番目). Fbxw7 regulates lipid metabolism and cell fate decisions in the mouse liver. J Clin Invest, 121: 342-354, 2011. 査読有

脇(山内)
1.   Waki H, Iwabu M, Okada-Iwabu M(18人中1,9,10番目). Global Mapping of Cell-Type-Specific Open Chromatin by FAIRE-seq Reveals the Regulatory Role of the NFI Family in Adipocyte Differentiation. PLoS Genet, 7: e1002311, 2011. 査読有[脇]
2.   脇 裕典、中村正裕、山内敏正、門脇 孝. 脂肪細胞分化のエピゲノム制御. 最新医学社 最新医学 メタボリックシンドロームII(後篇)-メタボリックシンドロームの基礎- 66: 1344-1358, 2011.査読無[脇]
3.   脇 裕典山内敏正、門脇 孝. 脂肪細胞の分析学的検査の実際―高分子量アディポネクチンの測定法 医学書院 臨床検査 55: 587-591, 2011. 査読無[脇]
4.   脇 裕典山内敏正、門脇 孝. 脂肪細胞と転写因子ネットワーク研究:最近の展開―次世代シークエンサーが切り開くエピゲノム・転写因子研究. 医歯薬出版 医学のあゆみ エネルギー代謝転写因子ネットワークと生活習慣病 237: 655-660, 2011. 査読無[脇]

中里
1.   Imazu Y, Nakazato M(9人中9番目). Ghrelin ameliorates bleomycin-induced acute lung injury by protecting alveolar epithelial cells and suppressing lung inflammation. Eur J Pharmacol, 672: 153-158. 2011. 査読有
2.   Koshinaka K, Toshinai K, Ueno H, Yamaguchi H, *Nakazato M(8人中8番目). Therapeutic potential of ghrelin treatment for unloading-induced muscle atrophy in mice. Biochem Biophys Res Commun, 412: 296-301, 2011. 査読有
3.   Noguchi H, Nakazato M (5人中4番目). Ghrelin in small intestine, its contribution to regulation of food intake and body weight in cross-intestinal parabiotic rats. Endocr J, 58: 625-632, 2011. 査読有
4.   Wang H, *Ueno H, Nakazato M(6人中6番目). Glucagon-like peptide-1 and candesartan additively improve glucolipotoxicity in pancreatic β-cells. Metabolism, 60: 1081-1089, 2011. 査読有
5.   Noma K, Toshinai K, *Nakazato M(4人中4番目). Telmisartan suppresses food intake in mice via the melanocortin pathway. Obes Res Clin Pract, 5: e93-e100, 2011. 査読有
6.   Shiiya T, Ueno H, Toshinai K, *Nakazato M(11人中11番目). Significant lowering of plasma ghrelin but not des-acyl ghrelin in response to acute exercise in men. Endocr J, 58: 335-342, 2011. 査読有

清水
1.  Suzuki Y, Shimizu H (12人中3番目). Cell proliferation in visceral organs induced by ventromedial hypothalamic (VMH) lesions: Development of electrical VMH lesions in mice and resulting pathophysiological profiles.  Endocrine J, 58: 247-256, 2011. 査読有
2.  Shimizu H (9人中1番目). Glucagon plays an important role in the modification of insulin secretion by leptin.  Islets, 3: 150-154, 2011. 査読有
3.  Lee EY, Shimizu H (11人中4番目). Beneficial effects of ventromedial hypothalamus (VMH) lesioning on function and morphology of the liver after hepatectomy in rats.  Brain Res, 1421: 82-89, 2011. 査読有

船橋
1.  Hirata A, Kishida K, Funahashi T(6人中2,5番目). Qualitative score of systemic arteriosclerosis by vascular ultrasonography as a predictor of coronary artery disease in type 2 diabetes. Atherosclerosis, 219: 623-629, 2011. 査読有
2.  Okauchi Y, Kishida K, Funahashi T(11人中2,3番目). Cross-sectional and longitudinal study of association between circulating thiobarbituric acid-reacting substance levels and clinicobiochemical parameters in 1,178 middle-aged Japanese men - the Amagasaki Visceral Fat Study. Nutr Metab (Lond), 8: 82, 2011. 査読有
3.  Kishida K, Funahashi T(3人中1,2番目). Clinical significance of visceral fat reduction through health education in preventing atherosclerotic cardiovascular disease - Lesson from the Amagasaki Visceral Fat Study: A Japanese perspective. Nutr Metab (Lond), 8: 57, 2011. 査読有
4. Kishida K, Funahashi T(3人中1,2番目). Importance of Assessing the Effect of Statins on the Function of High-Density Lipoproteins on Coronary Plaque. Cardiovasc Hematol Disord Drug Targets, 2011 Apr 19. 査読有
5.  Nakagawa Y, Kishida K, Funahashi T(6人中2,5番目). Nocturnal falls of adiponectin levels in sleep apnea with abdominal obesity and impact of hypoxia-induced dysregulated adiponectin production in obese murine mesenteric adipose tissue. J Atheroscler Thromb,18: 240-247, 2011. 査読有

小川
1.  Li S, Ogawa W (9人中2番目) Role of S6K1 in regulation of SREBP1c expression in the liver. Biochem Biophys Res Commun, 412: 197-202, 2011. 査読有
2.  Deng L, Ogawa W (8人中3番目). Hepatitis C virus infection promotes hepatic gluconeogenesis through an NS5A-mediated, FoxO1-dependent pathway. J Virol, 85: 8556-8568, 2011
3.  Cao Y, Ogawa W (18人中11番目). PDK1-Foxo1 in agouti-related peptide neurons regulates energy homeostasis by modulating food intake and energy expenditure. PLoS One, 6: e18324, 2011

細田
1.  Naito M, Hosoda K(11人中10番目). Therapeutic impact of leptin on diabetes, diabetic complications, and longevity in insulin-deficient diabetic mice. Diabetes, 60: 2265-2273, 2011. 査読有
2.  Zhao M, Hosoda K, Tomita T(8人中6,7番目). Azilsartan treatment improves insulin sensitivity in obese spontaneously hypertensive Koletsky rats. Diabetes Obes Metab, 10: 1463-1326, 2011.査読有
3.  Iwakura H, Hosoda K(8人中5番目). Oxytocin and Dopamine Stimulate Ghrelin Secretion by the Ghrelin-Producing Cell Line, MGN3-1 in Vitro. Endocrinology, 152: 2619-2625, 2011. 査読有
4.  Yamada N, Hosoda K(7人中6番目).  Impaired CNS leptin action is implicated in depression associated with obesity. Endocrinology, 152: 2634-2643, 2011. 査読有

≪公募研究≫
[平成23年度~平成24年度
浮穴
1.  Ukena K, Vaudry H, Leprince J, Tsutsui K. Molecular evolution and functional characterization of the orexigenic peptide 26RFa and its receptor in vertebrates. Cell Tissue Res, 343: 475-481, 2011. 査読有
2.  Tobari Y,  Ukena K. (10人中7番目) Identification, localisation and functional implication of 26RFa orthologue peptide in the brain of zebra finch (Taeniopygia guttata). J Neuroendocrinol, 23: 791-803, 2011. 査読有

斎藤
1.  Mizusawa K, Saito Y(6人中5番目). *Takahashi A. Inhibiting roles of melanin-concentrating hormone for skin pigment dispersion in barfin flounder, Verasper moseri. General and Comparative Endocrinology,171:  75-81, 2011. 査読有
2.  Hamamoto A, *Saito Y(4人中4番目). Signalling pathway of the goldfish melanin-concentrating hormone receptor 1 and 2 Regulatory Peptides, 169: 6-12, 2011. 査読有
3.  長崎 弘、斎藤祐見子:MCH 「摂食制御の分子過程」生体の科学 62: 37-43, 2011.査読無
4.  児島将康、斎藤祐見子: 日本における生理活性ペプチド研究の流れとその展開 実験医学増刊号「代謝・内分泌ネットワークと医薬応用」29: 14-22, 2011. 査読無
5.  斎藤祐見子:MCHの最新の話題 実験医学増刊号「代謝・内分泌ネットワークと医薬応用」29: 54-59, 2011. 査読無
6.  斎藤祐見子、児島将康: 新規生理活性ペプチドの探索方法の進歩 実験医学増刊号「代謝・内分泌ネットワークと医薬応用」29: 80-85, 2011. 査読無
7.  斎藤祐見子:オーファンGPCR系とうつ病 日本薬理学会編集「実践治療薬」印刷中 査読無

中川
1.  Kumadaki S, Nakagawa Y (他16人5番目). Inhibition of ubiquitin ligase F-box and WD repeat domain-containing 7α (Fbw7α) causes hepatosteatosis through Krüppel-like factor 5 (KLF5)/peroxisome proliferator-activated receptor γ2 (PPARγ2) pathway but not SREBP-1c protein in mice. J Biol Chem, 286: 40835-40846, 2011. 査読有
2.  Saito R, Nakagawa Y(他16人9番目). Macrophage Elovl6 deficiency ameliorates foam cell formation and reduces atherosclerosis in low-density lipoprotein receptor-deficient mice. Arterioscler Thromb Vasc Biol, 31: 1973-1979, 2011. 査読有
3.  Karasawa T, Nakagawa Y(他17人9番目). Sterol regulatory element-binding protein-1 determines plasma remnant lipoproteins and accelerates atherosclerosis in low-density lipoprotein receptor-deficient mice. Arterioscler Thromb Vasc Biol, 31: 1788-1795, 2011 査読有

南野
1.  Odaka K, Minamino T (11人中7番目). In vivo tracking of transplanted mononuclear cells using manganese-enhanced magnetic resonance imaging. PLoS One, 6: e25487, 2011. 査読有
2.  Wu X, Minamino T (12人中11番目). Role of Jagged1 in arterial lesions after vascular injury.  Arterioscler Thromb Vasc Biol, 31: 2000-2006, 2011. 査読有

井上順
1.  Ono E, Inoue J(5人中4番目). Anti-obesity and anti-hyperglycemic effects of the dietary citrus limonoid nomilin in mice fed a high-fat diet. Biochem Biophys Res Commun, 410: 677-681, 2011. 査読有
2. Inoue J(9人中1番目). Glutamine stimulates the gene expression and processing of sterol regulatory element-binding proteins, thereby increasing the expression of their target genes. FEBS J, 278: 2739-2750, 2011. 査読有
3.  Hashidume T, Inoue J(4人中3番目). Consumption of soy protein isolate reduces hepatic SREBP-1c and lipogenic gene expression in wild-type mice, but not in FXR-deficient mice. Biosci Biotechnol Biochem, 75: 1702-1707, 2011. 査読有
4.  Yashiro T, Inoue J(5人中4番目). Chenodeoxycholic acid stabilization of LDL receptor mRNA depends on 3'-untranslated region and AU-rich element-binding protein. Biochem Biophys Res Commun, 409: 155-159, 2011. 査読有
5. Inoue J(8人中1番目).Identification of MIG12 as a mediator for stimulation of lipogenesis by LXR activation. Mol Endocrinol, 25:995-1005, 2011. 査読有
6. Inoue J(5人中1番目). Stabilization of small heterodimer partner mRNA by grape seed procyanidins extract in cultured hepatocytes. Mol Nutr Food Res, 55: 1052-1058, 2011. 査読有

井上啓
1.  Koyanagi M, Inoue H(11人中4番目). Ablation of TSC2 Enhances Insulin Secretion by Increasing the Number of Mitochondria through Activation of mTORC1. PLoS One, 6:e23238, 2011.

岩倉
1.  *Iwakura H(8人中1番目). Oxytocin and dopamine stimulate ghrelin secretion by the ghrelin-producing cell line, MGN3-1 in vitro. Endocrinology, 152: 2619-2625, 2011.  査読有
2.  岩倉浩、細田公則、有安宏之、海老原健、赤水尚史、中尾一和:「加齢と肥満」、最新医学66巻828-832、2011年

錦見
1.  *Nishikimi T(3人中1番目). Diverse molecular forms of plasma B-type natriuretic peptide in heart failure. Curr Heart Fail Rep, 8: 140-146, 2011. 査読有
2.  *Nishikimi T (3人中1番目). Current biochemistry molecular biology, and clinical relevance of natriuretic peptides. J Cardiol, 57; 131-140, 2011. 査読有
3.   Hata L, Nishikimi T (17人中16番目). Zinc-finger protein 90 negatively relulates neuron-restrictive silencer factor-mediated transcriptional repression of fetal cardiac genes. J Mol Cell Cardiol, 50: 972-981, 2011. 査読有

志内
1.   Saito K, Shiuchi T(8人中3番目). An enzymatic photometric assay for 2-deoxyglucose uptake in insulin-responsive tissues and3T3-L1 adipocytes. Analytical Biochem, 412: 9-17, 2011. 査読有
2.   Matsuo E, Shiuchi T(11人中9番目). Decreased intake of sucrose solutions in orexin knockout mice. J Mol Neurosci, 43: 217-224, 2011. 査読有

山縣
1.  Iwahashi H, *Yamagata K(9人中9番目). Clinical features of Japanese type 2 diabetics with insulinogenic index in normal range after treatment of glucotoxicity. Diabetol Int, 2: 208-213, 2011.査読有
2.  Wei F-Y, Yamagata K(13人中11番目). *Tomizawa K. Deficit of Lys-tRNA Modification by Cdkal1 Causes the Development of Type 2 Diabetes in Mice. J Clin Invest, 121: 3598-3608, 2011.査読有
3.  *Yamagata K(12人中1番目). Song W-J. Voltage-gated K+ channel KCNQ1 regulates insulin secretion in MIN6 b-cell line. Biochem Biophys Res Commun, 407: 620-625, 2011.査読有
4.  Sato Y, Yamagata K(9人中7番目). *Inoue M: Cellular hypoxia of pancreatic b-cells due to high levels of oxygen consumption for insulin secretion in vitro. J Biol Chem, 286: 12524-12532, 2011.査読有

前島
1.  Maejima Y, Iwasaki Y(6人中1,2番目). *Yada T. Peripheral oxytocin treatment ameliorates obesity by reducing food intake and visceral fat mass. Aging (Albany NY), 3: 1169-1177, 2011.
2.  Maejima Y, Iwasaki Y(4人中1,3番目). *Yada T. Insulin suppresses ghrelin-induced calcium signaling in neuropeptide Y of the hypothalamic arcuate nucleus. Aging (Albany NY), 3: 1092-1097, 2011.

豊島
1.  Sone H, Toyoshima H (170人中50番目). Serum level of triglycerides is a potent risk factor comparable to LDL cholesterol for coronary heart disease in Japanese patients with type 2 diabetes: subanalysis of the Japan Diabetes Complications Study (JDCS). J Clin Endocrinol Metab, 96:3448-56, 2011. 査読有
2.  Saito T, Toyoshima H (8人中5番目). Ectopic ACTH syndrome associated with large cell neuroendocrine carcinoma of the thymus. Intern Med, 50:1471-1475, 2011. 査読有

種子島
1.  Hong S, Tanegashima K(3人中2番目). XIer2 is required for convergent extension movements during Xenopus development. Int J Dev Biol, 55, 917-921, 2011. 査読有
2.  Tsuji K, Tanegashima K (8人中4番目). Application of N-C- or C-N-directed sequential native chemical ligation to the preparation of CXCL14 analogs and their biological evaluation. Bioorg Med Chem,19: 4014-4020, 2011. 査読有

北村
1.  Tanioka T, Kitamura T(9人中8番目). iNOS and NO donor decrease IRS-2 protein expression by promoting proteasome-dependent degradation in pancreatic beta cells: involvement of GSK-3b. J Biol Chem, 286: 29388-29396, 2011. 査読有
2.  Hirata M, Kitamura T(9人中6番目). Genetic defect in phospholipase Cδ1 protects mice from obesity by regulating thermogenesis and adipogenesis. Diabetes, 60: 1926-1937, 2011. 査読有

船戸
1.   *Funato H(5人中1番目). Fasting and high-fat diet alter histone deacetylase expression in the medial hypothalamus. PLoS One 6, e18950, 1-8, 2011

千田
1.  Chida D(6人中1番目). The role of glucocorticoids in pregnancy, parturition, lactation, and nurturing in melanocortin receptor 2-deficient mice. Endocrinology, 152 : 1652-1660, 2011. 査読有

菅波
1.  Itoh M, *Suganami T(9人中2番目). Melanocortin-4 receptor-deficient mice as a novel mouse model of non-alcoholic steatohepatitis. Am J Pathol, 179: 2454-2463, 2011. 査読有
2.  Tanaka M, *Suganami T(9人中2番目). Role of central leptin signaling in the starvation-induced alteration of B cell development.
J Neurosci, 31: 8373-8380, 2011. 査読有
3.  Ichioka M, *Suganami T(13人中2番目). Increased expression of macrophage-inducible C-type lectin in adipose tissue of obese mice and humans. Diabetes, 60: 819–826, 2011. 査読有
4.  Itoh M, *Suganami T(4人中2番目). Adipose tissue remodeling as homeostatic inflammation. Int J Inflam, 2011:720926, 2011. 査読有

増谷
1.  Nishizawa K, Masutani H(12人中7番目).Thioredoxin-interacting protein suppresses bladder carcinogenesis. Carcinogenesis, 32: 1459-1466, 2011. 査読有

海老原
1.  Naito M, Ebihara K(11人中3番目). Therapeutic impact of leptin on diabetes, diabetic complications, and longevity in insulin-deficient diabetic mice. Diabetes, 9: 2265- 2273, 2011. 査読有
2.  Zhao M, Ebihara K(8人中4番目). Azilsartan treatment improves insulin sensitivity in obese spontaneously hypertensive Koletsky rats. Diabetes Obes Metab, 12: 1123- 1129, 2011. 査読有

土田
1.  Nakamura M, Tsuchida K(8人中5番目). Single-walled carbon nanohorns as drug carriers: adsorption of prednisolone and anti-inflammatory effects on arthritis. Nanotechnology, 22: 465102, 2011.査読有
2.  Uezumi A, Tsuchida K (15人中13番目). Fibrosis and adipogenesis originate from a common mesenchymal progenitor in skeletal muscle. J. Cell Science, 124: 3654-3664, 2011. 査読有

【受賞】
菅波孝祥/東京医科歯科大学難治疾患研究所代謝医学分野・准教授
日本肥満学会・学術奨励賞(平成23年9月24日)
「肥満の脂肪組織における慢性炎症の分子機構の解明と医学応用」

岡本士毅(連携研究者)/生理学研究所・生殖内分泌系発達機構
日本獣医学会 生理学・生化学分科会・日本獣医学会生理学・生化学分科会奨励賞(平成23年9月20日)
「食餌嗜好姓に及ぼす視床下部室傍核CRHニューロンのAMPキナーゼ調節作用」

野村和弘(連携研究者)/神戸大学・大学院医学研究科 糖尿病・内分泌内科
日本糖尿病学会若手研究奨励賞(平成23年5月21日)
「転写コアクチベーターPGC1の新規アイソフォームPGC1αb/cの機能解析」

野村和弘(連携研究者)/神戸大学・大学院医学研究科 糖尿病・内分泌内科
第9回メタボリックシンドロームカンファレンス研究奨励賞(平成23年7月16日) 
「 PGC-1α新規バリアントによる運動時の骨格筋の脂肪燃焼と肥満・インスリン抵抗性の制御」

野村和弘(連携研究者)/神戸大学・大学院医学研究科 糖尿病・内分泌内科
平成23年度日本糖尿病協会 国際交流研究奨励賞(平成23年7月)
「 Role of alternative splicing variants of PGC-1α in regulation of fatty acid oxidation, body mass and insulin sensitivity」

野村和弘(連携研究者)/神戸大学・大学院医学研究科 糖尿病・内分泌内科
日本臨床分子医学会学術奨励賞(平成23年4月14日)
「 PGC1αスプライスングバリアントのエネルギー代謝制御における機能の検討」

南野徹/千葉大学・医学系研究科・循環病態医科学・講師
日本医師会医学研究奨励賞(平成23年11月1日)
「長寿・老化モデルマウスを用いた慢性炎症機構の解明」

中畑泰和/奈良先端科学技術大学院大学・バイオサイエンス研究科・助教
平成 23 年度科学技術分野の文部科学大臣表彰「若手科学者賞」(平成23年4月11日)
「エネルギー代謝による概日時計制御機構の研究」

浮穴和義/広島大学大学院総合科学研究科・准教授
(佐藤真実、岩越-浮穴栄子)
第63回日本動物学会中国四国支部大会 若手研究者優秀発表賞(平成23年5月15日)
「マウス視床下部における摂食調節に関わる新規遺伝子のmRNA発現解析」


■2010
【業績論文】
研究代表者、研究分担者は一重下線、corresponding authorは左に*印で明示
寒川
1.  Nakahara K, Miyazato M, Kangawa K(8人中6, 7番目). Comparison of feeding suppression by the anorexigenic hormones neuromedin U and neuromedin S in rats. J Endocrinol, 207: 185-193, 2010. 査読有
2.  Nakahara K, Miyazato M, Kangawa K(6人4中, 5番目). Nutritional and environmental factors affecting plasma ghrelin and leptin levels in rats. J Endocrinol, 207: 95-103, 2010. 査読有
3.  *Kaiya H, Miyazato M, Kangawa K(5人中4, 5番目). Two functional growth hormone secretagogue receptor (ghrelin receptor) type 1a and 2a in goldfish, Carassius auratus. Mol Cell Endocrinol, 327: 25-39, 2010. 査読有
4.  *Ida T, Miyazato M, Kangawa K(9人中2, 8番目). Purification and characterization of caprine ghrelin and its effect on growth hormone release. J Mol Neurosci, 42: 99-105, 2010. 査読有
5.  *Akamizu T, Kangawa K. Ghrelin for cachexia. J Cachexia Sarcopenia Muscl, 1: 169-176, 2010. 査読有

児島
1.   Ida T, Kojima M(9人中9番目). Purification and characterization of caprine ghrelin and its effect on growth hormone release. J Mol Neurosci, 42: 99-105, 2010. 査読有
2.   Nakashima Y, * Kojima M(10人中10番目). Neuromedin U is necessary for normal gastrointestinal motility and is regulated by serotonin. Ann N Y Acad Sci, 1200:104-111, 2010. 査読有
3.  Kojima M, Kangawa K. Ghrelin: more than endogenous growth hormone secretagogue. Ann N Y Acad Sci, 1200: 140-148, 2010. 査読有
4.   Nonoshita A, Kojima M(11人中7番目). Dynamics of placental ghrelin production and its receptor expression in a Dahl salt-sensitive rat model of intrauterine growth restriction. Placenta, 31: 358-364, 2010. 査読有

塩田
1.  Date Y, Kageyama H,  Takenoya F, Shioda S(12人中3, 5, 10番目). Neuropeptide W: an anorectic peptide regulated by leptin and metabolic state. Endocrinology, 151: 2200-2210, 2010. 査読有
2.  Kageyama H,  Takenoya F, Shioda S(4人中1,2,4番目). Neuronal circuits involving ghrelin in the hypothalamus-mediated regulation of feeding. Neuropeptides, 44: 133-138, 2010. 査読有(総説)
3.  Kojima K, Kageyama H, Shioda S(7人中4, 6番目).  Relationship between alpha-melanocyte-stimulating hormone- and neuropeptide Y-containing neurons in the goldfish hypothalamus. Gen Comp Endocrinol, 167: 366-372, 2010. 査読有
4.  Matsuo T, Kageyama H, Shioda S(7人中3, 5番目). Localization of neuroendocrine regulatory peptide-1 and-2 in human tissues. Regul Pept, 163: 43-48, 2010. 査読有
5.  Mishiro-Sato E, Kageyama H,Shioda S(14人中4, 12番目). Distribution of neuroendocrine regulatory peptide-1 and -2, and proteolytic processing of their precursor VGF protein in the rat. J Neurochem, 114: 1097-1106, 2010. 査読有
6.  Shiba K, Kageyama H, Takenoya F, Shioda S(4人中2,3,4番目). Galanin-like peptide and the regulation of feeding behavior and energy metabolism. FEBS J, 277: 5006-5013, 2010. 査読有(総説)
7.   Takenoya F, Kageyama H, Shioda S(6人中1,2, 6番目). Neuropeptide W: a key player in the homeostatic regulation of feeding and energy metabolism? Ann N Y Acad Sci, 1200: 162-169, 2010. 査読有(総説)
8.  Takenoya F, Kageyama H, Shioda S(9人中1, 3, 9番目). Distribution of neuropeptide W in the rat brain. Neuropeptides, 44: 99-106, 2010. 査読有
9.  Toshinai K, Kageyama H, Shioda S(9人中3, 7番目). Neuroendocrine regulatory peptide-2 regulates feeding behavior via the orexin system in the hypothalamus. Am J Physiol Endocrinol Metab, 299: E394-401, 2010. 査読有

箕越
1.  Misu H, Minokoshi Y(27人中22番目). A liver-derived secretory protein, selenoprotein P, causes insulin resistance. Cell Metabolism, 12: 483-495, 2010. 査読有
2.  Tanegashima K, Minokoshi Y(9人中8番目). Cxcl14 deficiency in mice attenuates obesity and inhibits feeding behavior in a novel environment. PLoS ONE, 5: e10321, 2010. 査読有
3.  Sasaki T, Minokoshi Y(8人中7番目). Induction of hypothalamic Sirt1 leads to cessation of feeding via agouti-related peptide. Endocrinology, 151: 2556-2566, 2010. 査読有
4.  Uchida K, Minokoshi Y(5人中4番目). Metabolic adaptation of mice in a cool environment. Pflügers Arch, 459: 765-774, 2010. 査読有

片桐   
1.  Nakatsu Y, Katagiri H(20人中14番目). Pin1 associates with and induces translocation of CRTC2 to the cytosol, thereby suppressing cAMP-responsive element transcriptional activity. J Biol Chem, 285: 33018-22027, 2010. 査読中
2.  Susaki E, Katagiri H(8人中7番目). Increased E4 activity in mice leads to ubiquitin-containing aggregates and degeneration of hypothalamic neurons resulting in obesity. J. Biol. Chem, 285: 15538-15547, 2010. 査読有
3.  Tominaga R, Katagiri H(9人中7番目).  The JNK pathway modulates expression and phosphorylation of 4E-BP1 in MIN6 pancreatic βcells under oxidative stress conditions. Cell Biochem Funct, 28: 387-393, 2010  査読有
4.  Chen C, Katagiri H(13人中11番目). Characterization of a novel murine preadipocyte line, AP-18, isolated from subcutaneous tissue: analysis of adipocyte-related gene expressions. Cell Biol Int, 34: 293-299, 2010. 査読有
5.  Knotts TA, Katagiri H(17人中12番目). Molecular Characterization of the Tumor Suppressor Candidate 5 Gene: Regulation by PPARγ and Identification of TUSC5 Coding Variants in Lean and Obese Humans. PPAR Research, 867678, 2010. 査読有

脇(山内)
1.  Iwabu M, *Yamauchi T, Okada-Iwabu M(26人中1,2,3番目). Adiponectin and AdipoR1 regulate PGC-1alpha and mitochondria by Ca(2+) and AMPK/SIRT1. Nature, 464:1313-1319, 2010. 査読有[山内]

中里
1.  Saitoh Y, Ueno H, Nakazato M(5人中5番目).: Candesartan attenuates fatty acid-induced oxidative stress and NAD(P)H oxidase activity in pancreatic β-cells. Diabetes Res Clin Pract, 90: 54-59, 2010. 査読有
2.  Takenoya F, Nakazato M, (6人中5番目). Neuropeptide W: a key player in the homeostatic regulation of feeding and energy metabolism? Ann NY Acad Sci, 1200: 162–169, 2010.
3.  Matsuo T, Yamaguchi H, *Nakazato M(7人中7番目). Localization of neuroendocrine regulatory peptide-1 and-2 in human tissues. Regul Pept, 163:43-48, 2010. 査読有
4.  Mishiro-Sato E, Yamaguchi H, Nakazato M(14人中13番目). Distribution of neuroendocrine regulatory peptide-1 and -2, and proteolytic processing of their precursor VGF protein in the rat. J Neurochem, 114: 1097-1106, 2010. 査読有
5.  Sawai N, Nakazato M(4人中3番目). Developmental and aging change of orexin-A and -B immunoreactive neurons in the male rat hypothalamus. Neurosci Lett, 468: 51-55, 2010. 査読有
6.  Takenoya F, Nakazato M(9人中8番目). Distribution of neuropeptide W in the rat brain. Neuropeptides, 44:99-106, 2010. 査読有
7.  Koshida R, Yamaguchi H, *Nakazato M(6人中6番目). A novel nonsense mutation in DMP1 gene in a Japanese family with autosomal recessive hypophosphatemic rickets. J Bone Miner Metab, 28: 585-590, 2010. 査読有
8.  Toshinai K, Yamaguchi H, *Nakazato M(9人中9番目). Neuroendocrine regulatory peptide-2 regulates feeding behavior via the orexin system in the hypothalamus. Am J Physiol, 299: E394-401, 2010. 査読有
9.  Date Y, Yamaguchi H, Nakazato M(12人中12番目). Neuropeptide W: an anorectic peptide regulated by leptin and metabolic state. Endocrinology, 151: 2200-2210, 2010. 査読有

清水
1.  *Tsuchiya T, Shimizu H (12人中2番目). Fasting concentrations of nesfatin-1 are negatively correlated with body mass index in non-obese males.  Clin Endocrinol, 73: 484-490, 2010. 査読有

船橋
1.   Okauchi Y, Kishida K, Funahashi T(12人中2,3番目). Absolute value of bioelectrical impedance analysis-measured visceral fat area with obesity-related cardiovascular risk factors in Japanese workers. J Atheroscler Thromb, 17: 1237-1245, 2010. 査読有
2.   Okauchi Y, Kishida K, Funahashi T(10人中2,3番目). 4-year follow-up of cardiovascular events and changes in visceral fat accumulation after health promotion program in the Amagasaki Visceral Fat Study. Atherosclerosis, 212: 698-700, 2010. 査読有
3.   Tamba S, Kishida K, Funahashi T(12人中3,11番目). Relationship between visceral fat accumulation and urinary albumin-creatinine ratio in middle-aged Japanese men.Atherosclerosis, 211: 601-605, 2010. 査読有
4.   Nakatsuji H, Kishida K, Funahashi T(10人中2,3番目). One-year reductions in body weight and blood pressure, but not in visceral fat accumulation and adiponectin, improve urinary albumin-to-creatinine ratio in middle-aged Japanese men. Diabetes Care, 33: e110-111, 2010. 査読有

小川
1.  Takashima M, Ogawa W (14人中2番目)Role of KLF15 in regulation of hepatic gluconeogenesis and metformin action. Diabete, 59: 1608-15, 2010. 査読有
2.  Iskandar K, Ogawa W (13人中7番目) PDK-1/FoxO1 pathway in POMC neurons regulates Pomc expression and food intake. Am J Physiol Endocrinol Metab, 298: E787-798, 2010
3.  Nishida Y, Ogawa W (9人中7番目).Regulation of muscle genes by moderate exercise. Int J Sports Med, 31: 656-670, 2010. 査読有
4.  Liu M, Ogawa W (9人中8番目). Resveratrol inhibits mTOR signaling by promoting the interaction between mTOR and DEPTOR. J Biol Chem, 285: 36387-94, 2010. 査読有

細田
1.  Iwakura H, Hosoda K(11人中8番目). Establishment of a Novel Ghrelin-Producing Cell Line. Endocrinology, 151: 695-705, 2010. 査読有
2.  Tomiyama K, Hosoda K(13人中10番目). Relevant use of Klotho in FGF19 subfamily signaling system in vivo. Proc Natl Acad Sci U S A, 26;107: 1666-1671, 2010. 査読有
3.  Yasue S, Hosoda K(20人中9番目). Adipose Tissue-Specific Regulation of Angiotensinogen in Obese Humans and Mice: Impact of Nutritional Status and Adipocyte Hypertrophy. Am J Hypertens, 23: 425-431, 2010. 査読有
4. 
Okada S, Tomita T, Hosoda K(20人中13番目). Adipose tissue-specific dysregulation of angiotensinogen by oxidative stress in obesity. Metabolism, 59: 1241-1251, 2010. 査読有



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