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京大神経内科 研究紹介 神経生理学
神経病理
神経化学
分子神経生物学
神経生理
神経生理学
池田 昭夫
松本 理器
下竹 昭寛
小林 勝哉

我々「臨床神経生理学研究グループ」(第3.5研究室)は、システム神経科学の考え方と方法を用いて臨床病態の研究を進めています。臨床活動そのものの紹介はここでは割愛して、以下には特に研究面の活動に関して紹介いたします。

臨床の問題点に立脚して、神経生理学的方法によるアプローチに加えて機能画像の方法も駆使して、
1)運動・言語・感覚統合等の高次中枢制御機構の研究
2)ヒトの難治てんかんの診断と治療の研究
3)運動異常症の病態と治療の研究
からなるテーマを継続・発展させています。
これらの研究に関連しましては、専門医療機関(国立療養所機構静岡てんかん・神経医療センター)、他大学(東京女子医大脳外科、佐賀大学大学院工学系研究科システム制御)とも常時共同研究を継続しており、また学内では脳神経外科および高次脳機能総合研究センターと共同研究を行っています。

1) 運動発現の中枢制御機構の研究
ヒトの固有補足運動野、前補足運動野などの運動関連野の機能:
難治てんかんの外科治療目的で脳表面に留置された電極から運動準備電位を検討し、ヒトの固有補足運動野は一次運動野と同様に運動準備電位の発生源であり、固有補足運動野内に準備電位の発生源としてsomatotopyを示すことを明らかにしてきました。
また前補足運動野も運動準備電位の発生源であり、身体部位のどこを動かしても共通した電極から準備電位が記録されることを見い出してきました。
さらに固有補足運動野と前補足運動野との差異を、背景速波活動の非同期化、随意運動の反復速度の違い、外的刺激に応じて運動を選択する機能(感覚運動連関)の検討により明らかにしてきました。
外側前頭葉では、発声・発語の準備機構、随意的運動抑制の準備機構、前頭前野における刺激の区別・判断・運動の選択に関わる機能を、それぞれフィールド電位の記録・解析から明らかにしてきました。さらに補足運動野症候群(両手の交代性運動が選択的にされる特異な状態です)に関連して、運動リズムと随意運動の研究を進めています(人見健文医員)。これらの一連の所見は、脳機能局在の検査方法として、現在脳外科の機能温存手術に臨床応用されています。

2)ヒトの難治てんかんの診断と治療の研究
a) ヒトのてんかん焦点の病態研究と臨床応用:
てんかん発作時に「発作時直流電位」と呼ばれる緩徐な脳波変化がてんかん焦点の持続性の突発性脱分極変位 (PDS)に相当し、神経細胞とグリアの機能を反映することは1960年代に実験てんかんで示されていましたが、臨床的意義は全く不明でした。そこで難治部分てんかんにおける脳表面あるいは頭皮上からの発作時の脳波活動を分析して、発作時直流電位がヒトのてんかん原性領域のうちてんかん原性がより高い範囲を明らかにすることを初めて示すことができました。てんかん手術の焦点検索でcore epileptogenicityを知る上で大変有用で、徐々に臨床応用されています。また現在てんかん焦点のおけるグリアの機能異常が注目されていますが、DC電位はグリア細胞の受動的脱分極とその後の細胞外カリウムの緩衝作用の障害が大きく関わっていることが示唆されており、グリアとてんかん原性、特に皮質異形成との関連から現在検討中です。
その他に、特殊な脳波検査、FDG?PET、MEG、MRI等のてんかん焦点検索における有用性を検討してきました。脳外科との共同での海綿静脈洞内脳波記録法はヒトの内側側頭葉てんかんの発作時焦点の検索に有用であることを明らかにしました。
脳磁場計測によるてんかん焦点検索では、脳内てんかん性活動の信号強度の大きさと脳磁場計測の感度の関係をヒトで明らかにして、臨床応用における所見の意義づけにおける基本的な知識をもたらしました。
b) 難治焦点の電気生理学的方法による焦点抑制方法とのその機序の解明:
てんかん発作の多くはチャンネル病であるという考えにも一部立脚して、内因性の皮質の抑制系大脳皮質の磁気刺激方法を用いて賦活することが注目されています。我々はさらに低頻度の皮質電気刺激、高頻度電気刺激、低頻度磁気刺激の方法を用いて、てんかん焦点のてんかん性活動の抑制効果と、脳波活動の変化を見いだし、それぞれの作用機序も検討中です(木下真幸子医員)。また頭皮上のDC電位を指標にバイオフィードバックの手法で、脳の興奮性を内因的に調節する方法がドイツから近年報告されましたが、その機序と臨床応用に関して、海外の施設と共同研究を進めながら精力的に現在検討中です。これらはいずれも将来的にヒトのてんかんの治療方法としての応用が期待されています。

c) てんかん外科および脳機能温存療法に関連する高次大脳機能の評価:
温存すべき大脳皮質機能を明らかにすることと密接に関連して、運動野の機能検索以外に、側頭葉底部言語野が日本人では漢字機能に重要な役割を果たすこと、ヒトの前頭前野・運動前野・一次運動野の機能連関の解明、全頭型脳磁図により海馬由来の聴覚事象関連電位を解析して海馬の機能障害の側方性を推定すること、second sensory area の生理学的検討、temporoparietal junctionの機能的解析、などを明らかにしてきました。
皮質間のネットワークの解明は機能温存上極めて重要です。そこで単発の皮質電気刺激により、ヒトにおける脳葉間の連結を特に言語野間、運動皮質野間で明らかにすることができました(松本理器医員)。これは新しい方法functional tractograhyとして、画像情報との相補的な解析をさらに進めている最中です。

d)特異なてんかん病態の解明
一次感覚運動野由来の「focal inhibitory seizure」や前頭葉由来の全身脱力発作の発生機序、補足運動野発作での強直発作の発生機序、全般てんかんの強直発作で脳幹が症状発現に関与すること、日本における家族性側頭葉てんかんの存在などを報告してきました。

3)運動異常症の病態と治療の研究
パーキンソン病での随意運動の発現の障害と、ジストニアでの皮質機能の病態に関して、パーキンソン病とジストニアでは随意運動における感覚運動連関機構が障害されること、ジストニアで随意的筋弛緩の準備過程が皮質レベルで障害されることを明らかにしました。
また特に補足運動野の障害にともなう運動異常症の病態は正常機能の障害か類推されるものの皮質ネットワークのもとで特徴的な随意運動障害を示す、これを磁気刺激法および脳電位分析から検討しています。
ミオクローヌスの皮質病態を脳波的に分析して体性感覚誘発電位の諸成分が独立して巨大化することを明らかにした。また振戦の病態が皮質性ミオクローヌスであった臨床例を皮質振戦(cortical tremor)として初めて発表し、後に本邦で多発することが判明した「良性成人型家族性ミオクローヌスてんかん」の臨床病態を明らかにしてきました。
また現在欧米では運動異常症の中で最も問題になっているpsychogenic movement disorderに対しても運動準備電位の点から鑑別方法を明らかにしてきました。さらにパーキンソン病のbradykinesiaの発現、安静時振戦の発現機構を検討中です。

4)その他にも、ナルコレプシーの病態:Orexinとcataplexyの関連(clinico-biochemical correlation)、末梢神経障害におけるconduction blockの病態研究(人見健文医員)を、同時に進めてきました。てんかんに関する遺伝子多型の解明、てんかんのphenotypeとgenotypeの関連の解明(clinico-genotype correlation)は、神経内科内の分子遺伝学研究グループと共同で進めています。

 
臨床神経生理学部門の最近の業績リスト(2005年以降の英文原著)
【2016】
Nakatani M, Tsukino M, Takahashi R, Ikeda A. Periodic synchronous discharge occurred in an elderly with acute valacyclovir-associated encephalopathy. Rinsho Shinkeigaku. 2016;56:504-7.

Usami K, Matsumoto R, Sawamoto N, Murakami H, Inouchi M, Fumuro T, Shimotake A, Kato T, Mima T, Shirozu H, Masuda H, Fukuyama H, Takahashi R, Kameyama S, Ikeda A. Epileptic network of hypothalamic hamartoma: An EEG-fMRI study. Epilepsy Res. 2016;125:1-9.

Chen Y, Shimotake A, Matsumoto R, Kunieda T, Kikuchi T, Miyamoto S, Fukuyama H, Takahashi R, Ikeda A, Lambon Ralph MA. The 'when' and 'where' of semantic coding in the anterior temporal lobe: temporal representational similarity analysis of electrocorticogram data. Cortex. 2016;79:1-13.

Imamura H, Matsumoto R, Takaya S, Nakagawa T, Shimotake A, Kikuchi T, Sawamoto N, Kunieda T, Mikuni N, Miyamoto S, Fukuyama H, Takahashi R, Ikeda A. Network specific change in white matter integrity in mesial temporal lobe epilepsy. Epilepsy Res. 2016;120:65-72.

Ito S, Yano I, Hashi S, Tsuda M, Sugimoto M, Yonezawa A, Ikeda A, Matsubara K. Population Pharamacokinetic Modeling of Levetiracetam in Pediatric and Adult Patients With Epilepsy by Using Routinely Monitored Data. Ther Drug Monit. 2016;38:371-8.

Yamao Y, Kunieda K, Matsumoto R. Reply to commentary on "neural correlates of mirth and laughter: a direct electrical cortical stimulation study". Cortex. 2016;75:244-6.

Hitomi T, Kobayashi K, Sakurai T, Ueda S, Jingami N, Kanazawa K, Matsumoto R, Takahashi R, Ikeda A. Benign adult familial myoclonus epilepsy is a progressive disorder: no longer idiopathic generalized epilepsy. Epileptic Disord. 2016;18:67-72.

Neshige S, Kobayashi K, Shimotake A, Iemura T, Matsumoto R, Nishinaka K, Matsumoto M, Takahashi R, Ikeda A. An elderly woman with exaggerated startle reflex and unconscious drop attack. Neurology and Clinical Neuroscience. 2016, in press.

Uneno Y, Yokoyama A, Nishikawa Y, Funakoshi T, Ozaki Y, Aoyama I, Yamaguchi D, Morita S, Mori Y, Kanai M, Kinoshita H, Inoue T, Sawamoto N, Matsumoto R, Matsumoto S, Muto M. Paraneoplastic limbic encephalitis in human epidermal growth factor receptor-2-positive gastric cancer patient treated with trastuzumab-combined chemotherapy: case report and literature review. Internal Medicine. 2016, in press.

Fukuma K, Ihara M, Miyashita K, Motoyama R, Tanaka T, Kajimoto K, Ikeda A, Nagatsuka K. Right parietal source in Mahjong-induced seizure: a system epilepsy of focal origin. Clinical Case Reports. 2016, in press.

Phantom of oscillation: Operational definition bound to improve. Kinoshita M, Ikeda A. Clin Neurophysiol. 2016;127:8-9.
【2015】
Ritaccio A, Matsumoto R, Morrell M, Kamada K, Koubeissi M, Poeppel D, Lachaux JP, Yanagisawa Y, Hirata M, Guger C, Schalk G. Proceedings of the Seventh International Workshop on Advances in Electrocorticography. Epilepsy Behav. 2015;51:312-20.

Ikeda A. Commentary: We shall not lose past medical documents. Epilepsia. 2015;56:1712-3.

Usami K, Matsumoto R, Kobayashi K, Hitomi T, Shimotake A, Kikuchi T, Matsuhashi M, Kunieda T, Mikuni N, Miyamoto S, Fukuyama H, Takahashi R, Ikeda A. Sleep modulates cortical connectivity and excitability in humans: Direct evidence from neural activity induced by single-pulse electrical stimulation. Hum Brain Mapp. 2015;36:4714-29.

Yamao Y, Matsumoto R, Kunieda K, Arakawa Y, Kikuchi T, Shibata S, Ikeda A, Fukuyama H, Miyamoto S. A possible variant of negative motor seizure arising from the supplementary negative motor area. Clin Neurol Neurosurg. 2015;134:126-9.

Shimotake A, Matsumoto R, Ueno T, Kunieda T, Saito S, Hoffman P, Kikuchi T, Fukuyama H, Miyamoto S, Takahashi R, Ikeda A, Lambon Ralph MA. Direct Exploration of the Role of the Ventral Anterior Temporal Lobe in Semantic Memory: Cortical Stimulation and Local Field Potential Evidence From Subdural Grid Electrodes. Cereb Cortex. 2015;25:3802-17.

Yamao Y, Matsumoto R, Kunieda T, Shibata S, Shimotake A, Kikuchi T, Satow T, Mikuni N, Fukuyama H, Ikeda A, Miyamoto S. Neural correlates of mirth and laughter: a direct electrical cortical stimulation study. Cortex. 2015;66:134-40.

Kobayashi K, Matsumoto R, Matsuhashi M, Usami K, Shimotake A, Kunieda T, Kikuchi T, Mikuni N, Miyamoto S, Fukuyama H, Takahashi R, Ikeda A. Different Mode of Afferents Determines the Frequency Range of High Frequency Activities in the Human Brain: Direct Electrocorticographic Comparison between Peripheral Nerve and Direct Cortical Stimulation. PLoS One. 2015;10:e0130461.

Inoue Y, Yagi K, Ikeda A, Sasagawa M, Ishida S, Suzuki A, Yoshida K, and Japan Levetiracetam N01221 Study Group. Efficacy and tolerability of levetiracetam as adjunctive therapy in Japanese patients with uncontrolled partial- onset seizures. Psychiatry Clin Neurosci. 2015;69:640-8.

Fumuro T, Matsumoto R, Shimotake A, Matsuhashi M, Inouchi M, Urayama S, Sawamoto N, Fukuyama H, Takahashi R, Ikeda A. Network hyperexcitability in a patient with partial reading epilepsy: Converging evidence from magnetoencephalography, diffusion tractography, and functional magnetic resonance imaging. Clin Neurophysiol. 2015;126: 675-81.

Shibata S, Kunieda T, Inano R, Sawada M, Yamao Y, Kikuchi T, Matsumoto R, Ikeda A, Takahashi R, Mikuni N, Takahashi J, Miyamoto S. Risk factors for infective complications with long term subdural electrode implantation in patients with medically intractable partial epilepsy. World Neurosurg. 2015;84:320-6.

Hashi S, Yano I, Shibata M, Masuda S, Kinoshita M, Matsumoto R, Ikeda A, Takahashi R, Matsubara K. Effect of CYP2C19 polymorphisms on the clinical outcome of low-dose clobazam therapy in Japanese patients with epilepsy. Eur J Clin Pharmacol. 2015;71:47-59.

Kunieda T, Yamao Y, Kikuchi T, Matsumoto R. New Approach for Exploring Cerebral Functional Connectivity: Review of CCEP (Cortico-cortical evoked potential). Neurol Med Chir. 2015;55:374-82.

Matsumoto R, Mikuni N, Tanaka K, Usami K, Fukao K, Kunieda T, Takahashi Y, Miyamoto S, Fukuyama H, Takahashi R, Ikeda A. Possible induction of multiple seizure foci due to parietal tumour and anti-NMDAR antibody. Epileptic Disord. 2015;17:89-94.

Fumuro T, Matsuhashi M, Miyazaki T, Inouchi M, Hitomi T, Matsumoto R, Takahashi R, Fukuyama H, Ikeda A. Alpha- band desynchronization in human parietal area during reach planning. Clin Neurophysiol. 2015;126:756-62.

Kanazawa K, Matsumoto R, Imamura H, Matsuhashi M, Kikuchi T, Kunieda T, Mikuni N, Miyamoto S, Takahashi R, Ikeda A. Intracranially recorded ictal direct current shifts may precede high frequency oscillations in human epilepsy. Clin Neurophysiol. 2015;126:47-59.

Ota M, Shimizu T, Yoshida H, Kawata A, Kinoshita M, Nakano S, Isozaki E, Matsubara S. Clinical features and therapeutic responses of idiopathic orbital myositis. Neurology and Clinical Neuroscience. 2015;3:63-7.
【2014】
Inano R, Oishi N, Kunieda T, Arakawa Y, Yamao Y, Shibata S, Kikuchi T, Fukuyama H, Miyamoto S. Voxel-based clustered imaging by multi parameter diffusion tensor images for glioma grading. Neuroimage Clin. 2014; 5: 396-407.

Kanazawa K, Matsumoto R, Shimotake A, Kinoshita M, Otsuka A, Watanabe O, Tanaka K, Takahashi R, Ikeda A. Persistent frequent subclinical seizures and memory impairment after clinical remission in smoldering limbic encephalitis. Epileptic Disord. 2014;16:312-7.

Kobayashi K, Hitomi T, Matsumoto R, Kondo T, Kawamata J, Matsuhashi M, Hashimoto S, Ikeda H, Koide Y, Inoue Y, Takahashi R, Ikeda A. Long-term follow-up of cortical hyperexcitability in Japanese Unverricht-Lundborg disease. Seizure. 2014;23:746-50.

Takeuchi Y, Arakawa Y, Mikami Y, Matsumoto R, Miyamoto S. Dysembryoplastic neuroepithelial tumor with rapid recurrence of pilocytic astrocytoma component. Brain Tumor Pathol. 2014;31:144-8.

Yamao Y, Matsumoto R, Kunieda T, Arakawa Y, Kobayashi K, Usami K, Shibata S, Kikuchi T, Sawamoto N, Mikuni N, Ikeda A, Fukuyama H, Miyamoto S. Intraoperative dorsal language network mapping by using single-pulse electrical stimulation. Hum Brain Mapp. 2014;35:4345-61.

Fumoto N, Mashimo T, Masui A, Ishida S, Mizuguchi Y, Minamimoto S, Ikeda A, Takahashi R, Serikawa T, Ohno Y. Evaluation of seizure foci and genes in the Lgi1L385R/+ mutant rat. Neuroscience Research. 2014;80:69-75.

Jingami N, Matsumoto R, Ito H, Ishii A, Ihara Y, Hirose S, Ikeda A, Takahashi R. A novel SCN1A mutation in a cytoplasmic loop in intractable juvenile myoclonic epilepsy without febrile seizures. Epileptic Disord. 2014;16:227-31.

Murai T, Tohyama T, Kinoshita M. Recurrent diarrhea as a manifestation of temporal lobe epilepsy case report. Epilepsy & behavior Case Report. 2014;2:57-9.

Takaya S, Ikeda A, Mitsueda-Ono T, Matsumoto R, Inouchi M, Namiki C, Oishi N, Mikuni N, Ishizu K, Takahashi R, Fukuyama H. Temporal Lobe Epilepsy with Amygdala Enlargement: A Morphologic and Functional Study. J Neuroimaging. 2014;24:54-62.

Wang B, Wang X, Ikeda A, Nagamine T, Shibasaki H, Nakamura M. Automatic reference selection for quantitative EEG interpretation: Identification of diffuse/localised activity and the active earlobe reference, iterative detection of the distribution of EEG rhythms. Med Eng Phys. 2014;36:88-95.

Hitomi T, Takahashi R, Ikeda A. Recent advance in research of benign adult familial myoclonus epilepsy (BAFME): is BAFME a progressive disorder?. Rinsho Shinkeigaku. 2014;54:1142-5. Japanese.

Tojima M, Hitomi T, Jingami N, Tanioka K, Yamakado H, Matsumoto R, Takahashi Y, Ikeda A, Takahashi R. Two cases of acute onset of focal cortical reflex myoclonus following acute aseptic meningoencephalitis with positive anti-glutamate receptor autoantibody. Rinsho Shinkeigaku. 2014;54:543-9. Japanese.

Lu¨ders H, Amina S, Bailey C, Baumgartner C, Benbadis S, Bermeo A, Carreno M, Devereaux M, Diehl B, Eccher M, Edwards J, Fastenau P, Fernandez Baca-Vaca G, Godoy J, Hamer H, Hong SB, Ikeda A, Kahane P, Kaiboriboon K, Kalamangalam G, Lardizabal D, Lhatoo S, Lu¨ders J, Mani J, Mayor C, Mesa Latorre T, Miller J, Morris HH, Noachtar S, O'Donovan C, Park J, Perez-Jimenez MA, Rona S, Rosenow F, Shahid A, Schuele S, Skidmore C, Steinhoff B, Szabo´ CA´, Sweet J, Tandon N, Tanner A, Tsuji S. Proposal: different types of alteration and loss of consciousness in epilepsy. Epilepsia. 2014;55:1140-4.

Inoue T, Matsumoto R, Ikeda A. Treatment of epilepsy in patients of adolescence and adulthood. Nihon Rinsho. 2014;72:853-8. Japanese.

Shibasaki H, Nakamura M, Sugi T, Nishida S, Nagamine T, Ikeda A. Automatic interpretation and writing report of the adult waking electroencephalogram. Clin Neurophysiol. 2014;125:1081-94.
【2013】
Araki Y, Minakawa EN, Ono M, Matsumoto R, Kinoshita M. Topiramate add-on therapy for adult patients with refractory epilepsy in Japan. Epilepsy and Seizure. 2013;6:10-18.

Enatsu R, Matsumoto R, Piao Z, O'Connor T, Horning K, Burgess RC, Bulacio J, Bingaman W, Nair DR. Cortical negative motor network in comparison with sensorimotor network: A cortico-cortical evoked potential study. Cortex. 2013;49:2080-96.

Hitomi T, Kobayashi K, Jingami N, Nakagawa T, Imamura H, Matsumoto R, Kondo T, Chin K, Takahashi R, Ikeda A. Increased clinical anticipation with maternal transmission in benign adult familial myoclonus epilepsy in Japan. Epileptic Disorders. 2013;15:428-32.

Inouchi M, Matsumoto R, Taki J, Kikuchi T, Mitsueda-Ono T, Mikuni N, Wheaton L, Hallett M, Fukuyama H, Shibasaki H, Takahashi R, Ikeda A. Role of posterior parietal cortex in reaching movements in humans: Clinical implication for 'optic ataxia'. Clin Neurophysiol. 2013;124:2230-41.

Kunieda T, Mikuni N, Shibata S, Inano R, Yamao Y, Kikuchi T, Matsumoto R, Takahashi J, Ikeda A, Fukuyama H, Miyamoto S. Long-term seizure outcome following resective surgery for epilepsy: To be or not to be completely cured? Neurol Med Chir (Tokyo). 2013;53:805-13.

Mitsueda-Ono T, Ikeda A, Sawamoto N, Aso T, Hanakawa T, Kinoshita M, Matsumoto R, Mikuni N, Amano S, Fukuyama H, Takahashi R. Internal structural changes in the hippocampus observed on 3-Tesla MRI in patients with mesial temporal lobe epilepsy. Internal Medicine. 2013;52:877-85.

Morimoto E, Kanagaki M, Okada T, Yamamoto A, Mori N, Matsumoto R, Ikeda A, Mikuni N, Kunieda T, Paul D, Miyamoto S, Takahashi R, Togashi K. Anterior temporal lobe white matter abnormal signal (ATLAS) as an indicator of seizure focus laterality in temporal lobe epilepsy: comparison of double inversion-recovery, FLAIR and T2W MR imaging. Eur Radiol. 2013;23:3-11.

Morimoto E, Okada T, Kanagaki M, Yamamoto A, Fushimi Y, Matsumoto R, Takaya S, Ikeda A, Kunieda T, Kikuchi T, Paul D, Miyamoto S, Takahashi R, Togashi K. Evaluation of Focus Laterality in Temporal Lobe Epilepsy: A Quantitative Study Comparing Double Inversion-Recovery MR Imaging at 3T with FDG-PET. Epilepsia. 2013;54:2174-83.

Murahara T, Kinoshita M, Matsui M, Yamashita K, Ikeda A, Takahashi R. Prolonged ictal monoparesis with parietal PLEDs. Epileptic Disord. 2013;15:197-202.

Takeuchi Y, Arakawa Y, Mikami Y, Matsumoto R, Miyamoto S. Dysembryoplastic neuroepithelial tumor with rapid recurrence of pilocytic astrocytoma component. Brain Tumor Pathol. 2013;31:144-8.

Usami K, Matsumoto R, Kunieda T, Shimotake A, Matsuhashi M, Miyamoto S, Fukuyama H, Takahashi R, Ikeda A. Pre-SMA actively engages in conflict processing in human: A combined study of epicortical ERPs and direct cortical stimulation. Neuropsychologia. 2013;51:1011-7.

Kinoshita M, Ikeda A. Paroxysmal symptoms in the elderly; epileptic seizures or not. Nihon Rinsho. 2013;71:1858-63. Japanese.

Nakaoku Y, Maki T, Kanazawa K, Matsumoto R, Fukuyama H, Takahashi R, Ikeda A. A case of smoldering anti-leucine-rich glioma-inactivated 1 (LGI1) antibody-associated limbic encephalitis with faciobrachial dystonic seizure. Rinsho Shinkeigaku. 2013;53:706-11. Japanese.

Yamao Y, Kunieda T, Kikuchi T, Matsuhashi M, Sawamoto N, Matsumoto R, Okada T, Miyamoto S, Ikeda A. Neuroimaging in epilepsy. Brain Nerve. 2013;65:573-81. Japanese. 
【2012】
Matsumoto R, Kunieda T, Takahashi R, Ikeda A. Clinical epileptology and clinical system neuroscience: two sides of the same coin. Rinsho Shinkeigaku. 2012;52:1084-7. Japanese.

Toma K, Taguchi K, Ikeda A, Nishinaka K, Udaka F, Kameyama M. The medial temporal area and parietal lobe are involved in epileptic polyopia and palinopsia: A case report. Rinsho Shinkeigaku. 2012;52:651-5. Japanese.

Hitomi T, Oga T, Tsuboi T, Yoshimura C, Kato T, Ikeda A, Takahashi R, Chin K. Transient increase in epileptiform discharges after the introduction of nasal continuous positive airway pressure in a patient with obstructive sleep apnea and epilepsy. Intern Med. 2012;51:2453-6.

Matsumoto R, Kunieda T, Ikeda A. In vivo investigation of human brain networks by using cortico-cortical evoked potentials. Brain Nerve. 2012;64:979-91. Japanese.

Baulac S, Ishida S, Mashimo T, Boillot M, Fumoto N, Kuwamura M, Ohno Y, Takizawa A, Aoto T, Ueda M, Ikeda A, LeGuern E, Takahashi R, Serikawa T. A rat model for LGI1-related epilepsies. Hum Mol Genet. 2012;21:3546-57.

Lu¨ders HO, Amina S, Baumgartner C, Benbadis S, Bermeo-Ovalle A, Devereaux M, Diehl B, Edwards J, Baca-Vaca GF, Hamer H, Ikeda A, Kaiboriboon K, Kellinghaus C, Koubeissi M, Lardizabal D, Lhatoo S, Lu¨ders J, Mani J, Mayor LC, Miller J, Noachtar S, Pestana E, Rosenow F, Sakamoto A, Shahid A, Steinhoff BJ, Syed T, Tanner A, Tsuji S. Modern technology calls for a modern approach to classification of epileptic seizures and the epilepsies. Epilepsia. 2012;53:405-11.

Hitomi T, Kondo T, Kobayashi K, Matsumoto R, Takahashi R, Ikeda A. Clinical anticipation in Japanese families of benign adult familial myoclonus epilepsy. Epilepsia. 2012;53:e33-6.

Matsumoto R, Nair DR, Ikeda A, Fumuro T, Lapresto E, Mikuni N, Bingaman W, Miyamoto S, Fukuyama H, Takahashi R, Najm I, Shibasaki H, Lu¨ders HO. Parieto-frontal network in humans studied by cortico-cortical evoked potential. Hum Brain Mapp. 2012;33:2856-72.

Kikuchi T, Matsumoto R, Mikuni N, Yokoyama Y, Matsumoto A, Ikeda A, Fukuyama H, Miyamoto S, Hashimoto N. Asymmetric bilateral effect of the supplementary motor area proper in the human motor system. Clin Neurophysiol. 2012;123:324-34.

Tanioka K, Nagao M, Yamamoto M, Matsumura Y, Tabu H, Matsushima A, Uemura K, Matsumoto R, Ito Y, Takakura S, Takahashi R, Ichiyama S. Disseminated Nocardia farcinica infection in a patient with myasthenia gravis successfully treated by linezolid: a case report and literature review. J Infect Chemother. 2012;18:390-4.
【2011】
Azuma M, Ito I, Matsumoto R, Hirai T, Mishima M. Pulmonary hemorrhage induced by epileptic seizure. Heart and Lung: J Acute and Critical Care Epub, 2011

Hitomi T, Ikeda A, Inouchi M, Imamura H, Nakagawa T, Fumuro T, Matsumoto R, Takahashi R :Transient myoclonic state with asterixis: Primary motor cortex hyperexcitability is correlated with myoclonus. Intern Med 50: 2303-2309, 2011

Hitomi T, Ikeda A, Kondo T, Imamura H, Inouchi M, Matsumoto R, Terada K, Kanda M, Matsuhashi M, Nagamine T , Shibasaki H, Takahashi R: Increased cortical hyperexcitability and exaggerated myoclonus with aging in benign adult familial myoclonus epilepsy. Mov Disord 26: 1509-1514, 2011

Imamura H, Matsumoto R, Inouchi M, Matsuhashi M, Mikuni N, Takahashi R, Ikeda A: Ictal wideband ECoG: Direct comparison between ictal slow shifts and high frequency oscillations. Clin Neurophysiol 122: 1500-1504, 2011

Ji Z, Sugi T, Goto S, Wang X, Ikeda A, Nagamine T, Shibasaki H, Nakamura M. An automatic spike detection system based on elimination of false positives using the large-area context in the scalp EEG, IEEE Trans Biomed Eng. 58:2478-88, 2011

Kobayashi K, Matsumoto R, Kondo T, Kawamata J, Hitomi T, Inouchi M, Matsuhashi M, Takahashi R, Ikeda A: Decreased cortical excitability in Unverricht-Lundborg disease in the long-term follow-up: A consecutive SEP study. Clin Neurophysiol 122: 1617-1621, 2011

Matsumoto R, Imamura H, Inouchi M, Nakagawa T, Yokoyama Y, Matsuhashi M, Mikuni N, Miyamoto S, Fukuyama H, Takahashi R and Ikeda A: Left anterior temporal cortex actively engages in speech perception: A direct cortical stimulation study. Neuropsychologia 49: 1350-1354, 2011

Matsumoto R, Nair DR, Ikeda A, Fumuro T, Lapresto E, Mikuni N, Bingaman W, Miyamoto S, Fukuyama H, Takahashi R , Najm I, Shibasaki H and Lu¨ders HO: Parieto-frontal network in humans studied by cortico-cortical evoked potential. Hum Brain Mapp. E-pub. doi: 10.1002/hbm.21407, 2011

Mitsueda-Ono T, Ikeda A, Inouchi M, Takaya S, Matsumoto R, Hanakawa T, Sawamoto N, Mikuni N, Fukuyama H, Takahashi R: Amygdalar enlargement in patients with temporal lobe epilepsy. J Neurol Neurosurg Psychiatry 82: 652-657, 2011

Naito E, Matsumoto R, Hagura N, Oouchida Y, Tomimoto H, Hanakawa T: Importance of precentral motor regions in human kinesthesia: A single case study. Neurocase 17: 133-147, 2011

Tanioka K, Nagao M, Yamamoto M, Matsumura Y, Tabu H, Matsushima A, Uemura K, Matsumoto R, Ito Y, Takakura S, Takahashi R and Ichiyama S: Disseminated Nocardia farcinica infection in a patient with myasthenia gravis successfully treated by linezolid: a case report and literature review. J Infection and Chemotherapy:1-5, 2011

Zhang X, Wang X, Sugi T, Ikeda A, Nagamine T, Shibasaki H, Nakamura M. Automatic interpretation of hyperventilation-induced electroencephalogram constructed in the way of qualified electroencephalographer's visual inspection. Med Biol Eng Comput. 49:171-80, 2011
【2010】
Iwasaki M, Enatsu R, Matsumoto R, Novak E, Thankappen B, Piao Z, O'Connor R T, Horning K, Bingaman W, Nair D: Accentuated cortico-cortical evoked potentials in neocortical epilepsy in areas of ictal onset. Epileptic Disord 12: 292-302, 2010

Kawamata J, Ikeda A, Fujita Y, Usui K, Shimohama S, Takahashi R: Mutations in LGI1 gene in Japanese families with autosomal dominant lateral temporal lobe epilepsy: the first report from Asian families. Epilepsia 51: 690-3, 2010

Kinoshita M, Hitomi T, Matsuhashi M, Nakagawa T, Nagamine T, Sawada H, Shibasaki H, Takahashi R, Ikeda A: How does voluntary movement stop resting tremor? Clin Neurophysiol 121: 983-5, 2010

Maki T, Matsumoto R, Kohara N, Kondo T, Son I, Mezaki T, Nishino I, Ikeda A, Takahashi R: Rippling is not always electrically silent in rippling muscle disease: a case report. Muscle Nerve 43: 601-5, 2010
【2009】
Hanakawa T, Mima T, Matsumoto R, Abe M, Inouchi M, Urayama SI, Anami K, Honda M, Fukuyama H: Stimulus-response profile during single-pulse transcranial magnetic stimulation to the primary motor cortex. Cereb Cortex 19:2605-2615, 2009

Ikeda A, Hirasawa KI, Kinoshita M, Hitomi T, Matsumoto R, Mitsueda T, Taki JY, Inouch M, Mikuni N, Hori T , Fukuyama H, Hashimoto N, Shibasaki H and Takahashi R: Negative motor seizure arising from the negative motor area: Is it ictal apraxia? Epilepsia 50: 2072-2084, 2009

Iseki K, Ikeda A, Kihara T, Kawamoto Y, Mezaki T, Hanakawa T, Hashikawa K, Fukuyama, Shibasaki H: Impairment of the cortical GABAergic inhibitory system in catatonic stupor. A case report with neuroimaging. Epileptic Diord 11: 126-31, 2009

Minakawa EN, Matsumoto R, Kinoshita M. Topiramate induced agranulocytosis. BMJ Case Rep. 2009;2009. pii: bcr11.2008.1273. Epub 2009 Jun 5

Takaya S, Mikuni N, Mitsueda T, Satow T, Taki J, Kinoshita M, Miyamoto S, Hashimoto N, Ikeda A, Fukuyama H: Improved cerebral function in mesial temporal lobe epilepsy after subtemporal amydgalohoppocampectomy. Brain 132: 185-194, 2009

Usui K, Ikeda A, Nagamine T, Matsubayashi J, Matsumoto R, Hiraumi H, Kawamata J, Matsuhashi M, Takahashi R, Fukuyama H: Abnormal auditory cortex with giant N100m signal in patients with autosomal dominant lateral temporal lobe epilepsy. Clin Neurophysiol 120:1923-1926, 2009

Usui K, Ikeda A, Nagamine T, Matsuhashi M, Kinoshita M, Mikuni N, Miyamoto S, Hashimoto N, Fukuyama H, Shibasaki H: Temporal dynamics of Japanese morphogram and syllabogram processing in the left basal temporal area studied by event-related potentials. J Clin Neurophysiolol 26: 160-166, 2009
【2008】
Enatsu R, Mikuni N, Usui K, Matsubayashi J, Taki J, Begum T, Matsumoto R, Ikeda A, Nagamine T, Fukuyama H and Hashimoto N : Usefulness of MEG magnetometer for spike detection in patients with mesial temporal epileptic focus. Neuroimage 41:1206-1219, 2008

Kinoshita M, Takahashi R, Ikeda A: Application of the 2001 diagnostic scheme and the 2006 ILAE report of seizure and epilepsy: a feedback from the clinical practice of adult epilepsy. Epileptic Disord 10: 206-12, 2008

Matsumoto R, Okada T, Mikuni N, Mitsueda-Ono T, Taki J, Sawamoto N, Hanakawa T, Miki Y, Hashimoto N, Fukuyama H , Takahashi R and Ikeda A: Hemispheric asymmetry of the arcuate fasciculus: A preliminary diffusion tensor tractography study in patients with unilateral language dominance defined by Wada test. J Neurol 255:1703-1711, 2008
【2007】
Hitomi T, Kaji R, Murase N, Kohara N, Mezaki T, Nodera H, Ikeda A, Shibasaki H: Dynamic change of proximal conduction in demyelinating neuropathies: a cervical magnetic stimulation combined with maximum voluntary contraction. Clin Neurophysiol 118: 741-750, 2007

Komori M, Tanaka M, Muramoto E, Ohno M, Matsumoto R, Murase N, Kitagawa N, Saida T. (2007): Mitoxantrone for the treatment of Japanese patients with multiple sclerosis. Clin Neurology 47: 401-406, 2007

Kinoshita M, Ikeda A, Begum T, Terada K, Shibasaki H: Efficacy of low-dose, add-on therapy of clobazam (CLB) is produced by its major metabolite, N-desmethyl-CLB. J Neurol Sci 263: 44-8, 2007

Matsumoto R, Nair DR, LaPresto E, Bingaman W, Shibasaki H, Lu¨ders HO: Functional connectivity in human cortical motor system: A cortico-cortical evoked potential study. Brain 130: 181-197, 2007

Mikuni N, Okada T, Taki J, Matsumoto R, Nishida N, Enatsu R, Hanakawa T, Ikeda A, Miki Y, Urayama S, Fukuyama H and Hashimoto N: Fibers from the dorsal premotor cortex elicit motor-evoked potential in a cortical dysplasia. Neuroimage 34:12-18, 2007

Mikuni N, Okada T, Nishida N, Taki J, Enatsu R, Ikeda A, Miki Y, Hanakawa T, Fukuyama H, Hashimoto N: Comparison between motor evoked potential recording and fiber tracking for estimating pyramidal tracts near brain tumors. J Neurosurg 106:128-133, 2007
【2006】
Begum T, Ikeda A, Takahashi J, Tomimoto H, Shimohama S, Satow T, Nagamine T, Fukuyama H, Shibasaki H: Clinical outcome of patients with SREDA (Subclinical Rhythmic EEG Discharge of Adults). Intern Med 45:141-144, 2006

Begum T, Ikeda A, Yoshioka A, Sawada H, Fukuyama H, Shibasaki H: Rapid recovery from coma with multifocal PLEDs in a patient with severe dementia. Intern Med 45; 141-144, 2006

Begum T, Ikeda A, Matsuhashi M, Mikuni N, Miyamoto S, Hashimoto N, Nagamine T, Fukuyama H, Shibasaki H: Ipsilateral facial sensory and motor response to basal fronoto-temporal cortical stimulation: evidence suggesting direct activation of cranial nerves. Epilepsy Res 71: 216-222, 2006

Hitomi T, Ikeda A, Matsumoto R, Kinoshita M, Taki J, Usui K, Mikuni N, Nagamine T, Hashimoto N, Shibasaki H and Takahashi R: Generators and temporal succession of giant somatosensory evoked potentials in cortical reflex myoclonus: Epicortical recording from sensorimotor cortex. Clin Neurophysiol 117: 1481-1486, 2006

Ikeda A, Matsui M, Hase Y, Hitomi T, Takahashi Y, Shibasaki H, Shimohama S: "Burst and slow complexes" in nonconvulsive, epileptic status. Epileptic Disord 8: 61-64, 2006

Kinoshita M, Ikeda A, Taki J, Usui K, Matsumoto R, Mikuni N, Takahashi JB, Fukuyama H, Hashimoto N, Takahashi R: Heterogeneous epileptogenicity and cortical function within malformations of cortical development: A case report. J Neurol Sci 251:129-133, 2006

Lu¨ders HO, Acharya J, Alexopoulos A, Baumgartner C, Bautista J, Burgess R, Carreno M, Diehl B, Dinner D, Ebner A, Foldvary N, Godoy J, Hamer H, Ikeda A, Ka¨lle´n K, Kellinqhaus C, Kotaqal P, Lachhwani D, Loddenkemper T, Mani J, Matsumoto R, Mo¨ddel G, Nair D, Noachtar S, O'Donovan CA, Rona S, Rosenow F, Sshuele S, Szabo CA, Tandon N, Tanner A and Widdess-Walsh P: Are epilepsy classifications based on epileptic syndromes and seizure types outdated? Epileptic Disord 8: 81-85, 2006

Mikuni N, Ohara S, Ikeda A, Hayashi N, Nishida N, Taki J, Enatsu R, Matsumoto R, Shibasaki H, Hashimoto N: Evidence for a wide distribution of negative motor areas in the perirolandic cortex. Clin Neurophysiol 117: 33-40, 2006

Nakagawa Y, Matsumoto R, Ikeda A, Mikuni N, Matsuhashi M, Hanakawa T, Fukuyama H, Shimohama S: Focal cortical dysplasia at the primary somatosensory cortex could manifest both intractable partial epilepsy and cortical reflex myoclonus. Clin Neurology 46: 335-338, 2006

Ueki Y, Mima T, Koth MA, Sawada H, Saiki H, Ikeda A, Begum T, Reza F, Nagamine T, Fukuyama H: Altered plasticity of the human motor cortex in pakinson's disease. Ann Neurol 59: 60-71, 2006

Yamamoto J, Ikeda A, Kinoshita M, Matsumoto R, Satow T, Takeshita K, Matsuhashi M, Mikuni N, Miyamoto S, Hashimoto N and Shibasaki H: Low-frequency electric cortical stimulation decreases interictal and ictal activity in human epilepsy. Seizure 15:520-527, 2006

Ohara S, Ikeda A, Matsuhashi M, Satow T, Kunieda T, Mikuni N, Baba K, Mihara T, Miyamoto S, Shibasaki H: Bereitschaftspotentials recorded from the lateral part of the superior frontal gyrus in humans. Neurosci Lett 399: 1-5, 2006

Begum T, Ikeda A, Yoshioka A, Sawada H, Fukuyama H, Shibasaki H: Rapid recovery from coma with multifocal PLEDs in a patient with severe dementia. Intern Med 45:141-144, 2006

Oka Y, Inoue Y, Kanbayashi T, Kuroda K, Miyamoto M, Miyamoto T, Horiuchi F, Ikeda A, Shimizu T, Shibasaki H: Narcolepsy without cataplexy: two subtypes based on CSF hypoicretin-1/ orexin-A findings. Sleep 29:1439-1443, 2006

Mitsueda-Ono T, Ikeda A, Noguchi E, Takaya S, Fukuyama H, Shimohama S, Takahashi R: Epileptic polyopia with right temporal lobe epilepsy as studied by FDG-PET and MRI: a case report. J Neurol Sci 247: 109-111, 2006

Mikuni N, Miyamoto S, Ikeda A, Satow T, Taki J, Takahashi J, Ohigashi Y, Hashimoto N: Subtemporal hippocampectomy preserving the basal temporal language area for intractable mesial temporal lobe epilepsy- preliminary results. Epilepsia 47:1347-53, 2006

Takaya S, Hanakawa T, Hashikawa K, Ikeda A, Sawamoto N, Nagamine T, Ishizu K, Fukuyama H: Prefrontal hypofunction in patients with intractable mesial temporal lobe epilepsy. Neurology 67:1674-1676, 2006

Iinuma K, Morimoto K, Akiyama T, Ikeda A, Kurimoto M: Proposed diagnostic schema for the classification of epileptic seizures and eipilepsies (ILAE, 2001): proposal from Japan Epilepsy Society. Epilepsia 47: 1588-1591, 2006

Mikuni N, Ikeda A, Takahashi JA Nozaki K, Miyamoto S, taki W, Hashimoto N: A tsep-by-step resection guided by electrocorticography for nonmalignant brain tumors associated with long-term intractable epilepsy. Epilepsy Behav 8: 560-564, 2006
【2005】
Begum T, Mima T, Oga T, Hara H, Satow T, Ikeda A, Nagamine T, Fukuyama H, Shibasaki: Cortical mechanisms of unilateral voluntary motor inhibition in humans. Neurosci Res 53: 428-435, 2005

Ikeda A, Miyamoto S, Tomimoto H, Mikuni N, Fukuyama N, Hashimoto N: Effects of trans-sylvian approach on basal forebrain projection fibers: verbal memory decline in selective amygdalohippocampectomy. Epilepsia 46: 334, 2005

Ikeda A, Kurihara S, Shibasaki H: Possible anticipation in BAFME: examined three generations in a Japanese family. Mov Disord 20: 1076-1077, 2005

Kinoshita M, Ikeda A, Matsuhashi M, Matsumoto R, Hitomi T, Begum T, Usui K, Takayama M, Mikuni N, Miyamoto S, Hashimoto N and Shibasaki H: Electric cortical stimulation suppresses epileptic and background activities in neocortical epilepsy and mesial temporal lobe epilepsy. Clin Neurophysiol 116:1291-1299, 2005

Kinoshita K, Ikeda A, Begum T, Yamamoto J, Hitomi T, Shibasaki H: Low frequency repetitive transcranial magnetic stimulation for seizure suppression in patients with extratemporal lobe epilepsy - a pilot study. Seizure 14: 387-392, 2005

Matsumoto R, Ikeda A, Hitomi T, Aoki T, Hanakawa T, Miki Y, Tomimoto H, Shimohama S, Shibasaki H: Ictal monoparesis associated with lesions in the primary somatosensory area. Neurology 65: 1476-1478, 2005

Matsumoto R, Kinoshita M, Taki J, Hitomi T, Mikuni N, Shibasaki H, Fukuyama H, Hashimoto N, Ikeda A: In vivo epileptogenicity of focal cortical dysplasia: A direct cortical paired stimulation study. Epilepsia 46: 1744-1749, 2005

Matsumoto R, Nair DR, Bingaman W, Ikeda A, Shibasaki H, Lu¨ders HO: Interareal connectivity in the human language system: a cortico-cortical evoked potential study. Brain 127:2316-30, 2004

Mikuni N, Takayama M, Satow T, Yamada S, Hayashi H, Nishida N, Taki J, Enatsu R, Ikeda A, Miyamoto S, Hashimoto N: Evaluation of adverse effects in intracarotid propofol injection for Wada test. Neurology 65: 1813-6, 2005

Mikuni N, Ikeda A, Hayase Y, Amano S, Hanakawa T, Fukuyama H, Hashimoto N: Surgical resection of an epileptogenic cortical dysplasia in the deep foot sensorimotor area: a case report. Epilepsy Behav 7: 559-62, 2005

Murase N, Rothwell JC, Kaji R, Urushihara R, Nakamura K, Murayama N, Igasaki T, Sakata-Igasaki M, Mima T, Ikeda A, Shibasaki H: Subthreshold low-frequency repetitive transcranial magnetic stimulation over the premotor cortex modulates writer's cramp. Brain 128: 104-115, 2005

Nakamura M, Chen Q, Sugi T, Ikeda A, Shibaasaki H: Technical quality evaluation of EEG recording based on electtroencephalographers' knowledge. Med Eng Physics 27: 93-100, 2005

Nakaji K, Ikeda A, Oka Y, Tomimoto H, Shimohama S, Kanbayashi T, Shibasaki H: Hypersomnia caused by isolated angitis of the CNS. Intern Med 44: 883-885, 2005

Nishida N, Hayase, Y, Mikuni N, Enatsu R, Hayashi N, Takahashi JA, Nakashima Y, Ikeda A, Amano S, Hashimoto N: A nonspecific form of dysembryoplastic neuroepithelial tumor presenting with intractable epilepsy. Brain Tumor Pathol 22: 35−40, 2005

Takaya S, Matsumoto R, Namiki C, Kiyosu H, Isono O, Hashikawa K, Ikeda A, Fukuyama H: Frontal nonconvulsive status epilepticus manifesting somatic hallucinations. J Neurol Sci 234: 25-29, 2005

Usui N, Kotagal P, Matsumoto R, Kellinghaus C, Lu¨ders HO: Focal semiologic and electroencephalographic features in patients with juvenile myoclonic epilepsy. Epilepsia 46: 1668-1676, 2005

Ueki Y, Mima T, Oga T, Ikeda A, Hitomi T, Fukuyama H, Nagamine T, Shibasaki H: Dominance of ipsilateral coorticospinal pathway in congenital mirror movements. J Neurol Neurosurg Psychiatry 76: 276-279, 2005

Usui K, Ikeda A, Takayama M, Matsuhashi M, Satow T, Begum T, Kinoshita M, Miyamoto S, Hashimoto N, Nagamine T, Fukuyama H, Shibasaki H: Processing of Japanese morphogram and syllabogram in the left basal temporal area: electrical cortical stimulation studies. Cog Brain Res 24: 274-283, 2005
 
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